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Showing 1 to 20 of 312 for “"C57BL/6"”.
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Mechanisms of Compass Orientation in C57BL/6 Laboratory Mice
Compass orientation or menotaxis is defined as the ability to orient at a specific angle relative to a directional cue. Cues used for compass orientation include the sun, stars, moon, geomagnetic field and polarized light. While there is evidence in a variety of organisms for compass orientation, …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present …
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Vergleich von rekombinanten Vaccinia- und DNA-Vektoren zur Tumorimmuntherapie im C57BL/6-Mausmodell
… Vakzinen wurde in verschiedenen Tumormodellen in C57BL/6 Mäusen verglichen. Die auf dem eukaryotischen Expressionsvektor pCI basierende DNA-Vakzinierung induzierte einen sehr wirksamen, antigenspezifischen und langfristigen Schutz vor Muzin, CEA oder beta-Galactosidase exprimierenden Tumoren. Eine …
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Age and Gender Effects on Strain Response and Biomechanical Performance of C57BL/6 Mice
… bone with aging has become an area of interest. C57Bl/6 mice have been commonly used in various studies to investigate the changes in a bone with aging. In this study, C57Bl/6 mice were divided into three age groups: 6 months old, 12 months old and 22 months old. Each age group consisted of 6-7 …
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Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
… would interfere with the circadian rhythm of C57Bl/6 mice and induce both depressive-like and anxiety-like behaviours and that there would be sex-specific differences. Animals were either singly or group housed for a three week period where locomotor activity was measured. After this period …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… cells in aged (22 mo) calorie restricted (CR) C57Bl/6 mice. NK cells are innate immune cells capable of killing tumor or virus-infected cells. We used flow cytometry to analyze NK cell maturation in young ad libitum (AL) fed, young CR, aged AL, and aged CR mice. Aged CR mice had significantly …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
… system for identifying T-cell epitopes in C57BL mice by integrating relevant contributing factors, such as the antigen processing steps before MHC binding and thermostability, with the MHC binding predictions. Utilizing deep learning methods, we first trained and rigorously validated the …
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Acute Effects of Whole-Body Proton Irradiation on the Immune System of the C57BL/6 Mouse
… from a 60cobalt (60Co) source. Adult, female C57BL/6 mice were exposed to a single dose (3 Gy, 0.4 Gy/min dose rate) of either proton WBI at the Bragg peak, proton WBI at the entry plateau, or Co WBI, and sacrifice intervals were at 1,4, 7, and 10 days post- WBI. Flow cytometry analysis of the …
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A role for Dazl in commitment to gametogenic fate in embryonic germ cells of C57BL/6 mice
… XX and XY embryonic germ cell development in a C57BL/6 genetic background. I find that Dazl transcript is expressed in the XX and XY gonads starting from around E11.5. XX and XY Dazl -/- germ cells appear to arrest around E13.5 in the last cell type XX and XY germ cells share morphologically. In …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… dysregulation, and susceptibility to injury in C57BL/6 mice were investigated. For the first time, we show altered liver pathology during the early course of C. rodentium infection, characterized by periportal necrosis indicative of thrombic ischemic injury, correlating with distinct circulating …
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Efeito de dieta hipersódica e hiperenergética no remodelamento do tecido adiposo branco e marrom de camundongos C57BL/6
… glicídico e adiposidade corporal em camundongos C57BL/6 machos e fêmeas. Foram utilizados camundongos C57BL/6 machos e fêmeas. Aos 3 meses de idade, eles foram alimentados com dieta controle (C) ou dieta HFSS (high fat, sucrose and salt) por 6 ou 12 semanas, e com dieta HFSS por 6 semanas seguido …
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Schmerzhafte Mononeuropathie an C57BL/6 Mäusen: Studien mit neutralisierenden Antikörpern gegen Tumor-Nekrose-Faktor Alpha an zwei verschiedenen Läsionsmodellen
… einer schmerzhaften Mononeuropathie an der C57BL/6-Maus sowie deren Beeinflussung durch neutralisierende AK gegen TNF. Dafür wurden die Nn. ischiadici der Mäuse operativ manipuliert, zum einen in Form der CCI durch drei den Nerven einschnürende Ligaturen und zum anderen in Form der PST durch …
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Hepatic Apo E mRNA Levels in BALB/c and C57BL/6 Mice Fed Different Levels and Types of Oil
… the hepatic mRNA level of Apo E in BALB/c and C57BL/6 mice fed semipurified diets containing 3 or 20% corn oil. Although differences were not statistically significant, C57BL/6 mice fed 20% corn oil showed increased expression of Apo E while BALB/c fed 20% showed decreased expression. A fourth …
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Hepatic Apo E mRNA levels in BALB/c and C57BL/6 mice fed different levels and types of oil
… the hepatic mRNA level of Apo E in BALB/c and C57BL/6 mice fed semipurified diets containing 3 or 20% corn oil. Although differences were not statistically significant, C57BL/6 mice fed 20% corn oil showed increased expression of Apo E while BALB/c fed 20% showed decreased expression. A fourth …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… in an obese mouse model. Obese, 18-wk old, C57BL/6 mice were randomized to high-fat (45% of kcal) diets containing 5% cellulose, 10% cellulose, 10% short-chain fructooligosaccharides (scFOS) or 10% inulin and fed for 28 d. Distal ileum, cecum, and colon samples were collected for Ussing …
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Effects of Short-Term Exposure to Octylphenol and Genistein on the Immune System of C57BL/6 and (NZBxNZW)F1 Mice
… in adult, reproductively intact non-autoimmune C57BL/6 and pre-autoimmune (NZBxNZW)F1 males. Oral dosing of 0.1 mg, 1 mg, or 10 mg of octylphenol 3 times a week for 3 weeks did not affect the morphology or function of the thymus as assessed by its weight, thymocyte cellularity, proportion of …
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The Effects of Early Postnatal PCP Administration on Performance in Locomotor Activity, Reference Memory, and Working Memory Tasks in C57BL/6 Mice
… effects of early postnatal PCP administration in C57BL/6 mice. Mouse pups received daily administrations of either 10.0 mg/kg PCP or saline on postnatal (PN) days 5-15. After weaning, pups were assessed in locomotor activity, a reference memory task in the Morris water maze, and a spatial delayed …
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Untersuchungen des adjuvanten Effekts des viralen Tegumentproteins VP22 auf die Induktion Melanom-spezifischer cytotoxischer T-Zellen in C57BL/6 Mäusen nach DNA-Immunisierung
… Aktivierung TRP-2-spezifischer T-Zellen in der C57BL/6 Maus nach DNA Immunisierung evaluiert werden. Die Immunogenitaet der Vakzine sollte durch die Fusion von TRP-2 an VP22, dem Tegumentprotein des Herpes Simplex Virus 1, gesteigert werden. VP22 besitzt die Faehigkeit, interzellulaeren …
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