Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"C57/BL6"”.
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Nachweis des apoptoseinduzierenden Faktors in Lewis-Lung-Karzinom Zellüberstand nach Inkubation von Kulturmakrophagen der C57/BL6 Maus
Mehrere Untersuchungen zeigten bereits, daß Tumorzellen, sowie auch deren Überstände, verschiedene Funktionen von Kulturmakrophagen beeinflussen können. Aufgrund der Beobachtung, daß Tumorzellüberstände des Lewis-Lung-Karzinoms, reife Kulturmakrophagen nach verschiedenen Inkubationszeiten von 7, 12 …
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Mechanistic Insights into the Effects of Exercise on Inflammatory Responses
… altered following long-term exercise in mice. C57/Bl6 mice were randomly assigned into a control group and an exercise group. Various modes of exercise training programs were performed by the exercise group. BMDMs were isolated and were then stimulated with several inflammatory inducers. Our …
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[alpha](1,3)galactosyltransferase mediated gene therapy for cancer: developing new models and improving on existing ones
… stromal tumor, CA320M, derived from C57/BL6 alpha(1,3)galactosyltransferase knock-out mice. The approach, however, is based in part on the sensitivity of tumor cells to the effects of complement. Tumors expressing complement resistance factors such as membrane cofactor (CD46), decay …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… endosulfan, permethrin and their mixtures on C57/BL6 male mice thymocytes in vitro and to ascertain the mechanism by which these effects take place. Permethrin, a broad-spectrum synthetic pyrethroid, is a widely used insecticide in agriculture and public health. Endosulfan is a highly toxic …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… (mitochondrial copy number) alterations in C57/BL6 rodent models. These changes preceded overt disease onset, as classified by clinically utilized indices, which included the homeostatic model assessment for insulin resistance (HOMA-IR), the homeostatic model assessment for β-cell …
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Untersuchung der Rolle des Fas/FasL-Systems bei der Auslösung der Apoptose durch Tumorzellen in Fas-knock out-Makrophagen
… werden. <br>Um die Untersuchungszeitpunkte von C57/BL6-Mäusen auf Fas-k.o.-Mäuse übertragen zu können, wurde zuerst mit Hilfe des Reifemarkers Bm8, dem BrdU-Proliferationstest und dem Latexphagozytosetest gezeigt, dass sich die beiden Mäusearten in ihrer Kinetik nicht unterscheiden. <br>Bei der …
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… endotoxin treatments on glucose homeostasis in a C57/Bl6 mouse model. First, we tested the hypothesis in cell culture that short-term low-dose endotoxin treatments would enhance insulin-signaling and glycogen synthesis while long-term treatments would have inhibitory effects. Under our second …
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Counterattack: ein Prinzip der Metastasierung maligner Tumoren?
… <br>Für die Untersuchungen wurde ein Modell an C57/BL6 Mausmakrophagen verwendet, das <br>Aussagen über die apoptotische Aktivität von Makrophagen zuließ. <br>Um eine allgemeine Aussage hinsichtlich des Prinzips der Apoptoseinduktion zu erhalten, wurden <br>Tumorzelllinien unterschiedlicher …
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Charakterisierung monoklonaler Antikörper gegen die murine Fibrosarkomzellinie MCA102 und Rolle der B-Zellen in diesem Tumormodell
… wurde das <br>MCA102GP33-Tumorwachstum in C57/BL6-Mäusen (B6-Mäusen) und B-Zell defizienten <br>JHT-Mäusen verglichen. Es konnte ein verzögertes Tumorwachstum sowie ein vermehrtes <br>Abstoßen der Tumoren in JHT-Mäusen gezeigt werden. Dieser Effekt war weder auf eine <br>höhere Anzahl an …
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Characterisation of cardiac remodeling associated with pregnancy: providing insights to peripartum cardiomyopathy
… were assessed in pregnant wild type mice (C57/BL6) and healthy women. An invitro model of cardiac hypertrophy was then used to explore the involvement of pregnancy hormones in the regulation of cardiac hypertrophy. Finally, we assessed the circulatory level of growth differentiation 15 …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… This construct was then administered to C57/BL6 mice in the presence of titer max gold adjuvant. The induced antibodies were then examined through ELISA, 51Cr cytotoxic assays and a SCID mouse study involving MCF-7 induced tumors. While the induced antibody titers were not substantial …
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Evaluation of IP-10 and TNFalpha-transducing parvoviral vectors as antitumoral agents in animal glioblastoma models
… were used for inducing subcutaneous tumors in C57/Bl6 mice and human U87 glioblastoma cells produced subcutaneous tumors in cd1 swiss nude mice. The antitumoral effects mediated in vivo by recombinant and wild type parvoviruses (MVMp and H1) were investigated in these animal models. High …
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Die Rolle der Caspase-1 abhängigen Cytokine, IL-1β und IL-18, bei der hyperoxie-induzierten Schädigung des unreifen Gehirns.
… dass eine Behandlung von Han Wistar Ratten und C57/BL6 Mäusen mit einer Hyperoxie von 80% Sauerstoff, insbesondere nach 12-24 Stunden, zu einer verstärkten Neurodegeneration führt. Immunhistochemische Arbeiten weisen neben dem Vorkommen von Interleukin-18 und seinem Rezeptor IL-18Rα im Gehirn …
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Der Einfluss von pdHGF auf die Wundheilung
… of pdHGF in a physiological organism, C57/BL6 mice were used in our second experimental model. Therefore pdHGF was injected subcutaneously in order to find out its impact on hair growth as a indicator for cell proliferation and regeneration. For the first time, our study highlights that …
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Vaccination and immunological memory
… 4 following in vitro activation with OVAp, into C57/BL6 wild type recipient mice which were immune to TT. Recipient mice were then challenged with TT antigen and susceptibility of OT-II cells to bystander activation and proliferation was tested. Naïve T cells were found not to be influenced, but …
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Exploring the relationship between shifts in high-density lipoprotein (HDL) particle subclass distribution/functionality and cardiac function in doxorubicin (DOX)-induced cardiotoxicity
… 3 weeks). Breast cancer was induced in female C57/Bl6 mice (6-8 weeks old) by subcutaneous injection of the E0771 cell line. Once a palpable tumour formed, DOX (5 mg/kg, i.p.) was given weekly for 5 weeks. The following groups were considered: Control (C, n=17), DOX (D, n=17), Tumour (T, n=20) …
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Effects of air pollution on vascular thrombosis
… stenosis and mechanical injury), first in male C57/Bl6 mice and later in male Wistar rats, were unsuccessful. An alternative approach, using ferric chloride (FeCl3) to induce chemical injury to the rat carotid artery was found to produce reliable and reproducible thrombotic occlusion: this model …
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Ethanolamine as a cardioprotective agent in doxorubicin-induced cardiotoxicity
… ethanolamine were used to treat male and female C57/Bl6 mice exposed to acute (one dose of 20 mg/kg doxorubicin) or chronic (3 doses of 6mg/kg doxorubicin administered once per week for 3 weeks) treatment. After 1 week (acute) or 6 weeks (chronic) of treatment, cardiac biomarkers, and cardiac …
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The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
… or saline (0.9% NaCl) was administered to male C57/Bl6 mice every 2 days for a period of 7 days. Analysis of dopamine and Mn was determined 24 h from the last Mn injection. When the higher dose of Mn was administered (50 mg/kg), an additional two time points were evaluated: 7 and 21 days from …
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