Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"C500 - Microbiology"”.
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Investigation of methods for logging and recording the temperature of food samples submitted for microbiological analysis
The quality of results from the microbiological examination of foods is affected by the quality of the sample taken and the provision of effective transport systems which prevent temperature deterioration of the samples during transit. This project has investigated and evaluated the factors which …
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Detection of periodontal bacteria in atherosclerotic plaque
This study aims to examine the role infection plays in the pathogenesis of atherosclerosis through the molecular identification of latent bacterial species present in atherosclerotic plaque tissue from the carotid artery. Immunohistological examination of the atherosclerotic plaque tissue revealed …
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Microbial degradation of polyester polyurethane
During the course of these studies, polyester polyurethane foam has been found to be readily degraded in soil and marine environments. The incorporation of the formulation biocide Vinyzene E.P. reduced the rate and extent of degradation in test material exposed to soil conditions, but was found to …
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Investigating contamination of dental-unit waterline systems and microbial biofilm ecology
Introduction: Biofilms within dental-unit waterlines (DUWLs) are acknowledged sources of contamination in the dental clinical environment and affect the quality of clinical treatment water. As a standard for reducing exposure to potentially harmful microorganisms, the Department of Health (DoH), UK …
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HSP70: a therapeutic biomarker for treatment of glioma
Gliomas are amongst the most malignant, invasive and recurrent forms of brain tumour with very short survival rate due to high chemoresistance. Recently, highly inducible molecular chaperones HSP70 and HSP90 are emerging as important anti-cancer targets. Previously, proteomic analysis had …
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Purification of human dna for dna profiling from body fluid contaminated soil using superparamagnetic iron oxide nanoparticles (spions).
Extraction of good quality DNA from soil samples is difficult due to the co-extraction of humic acid and phenolic compounds which can inhibit downstream DNA profiling of samples. Several methods are available for DNA extraction from soil including a number of commercially available kits. We used …
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An investigation into the direct and indirect effects induced by platelet-activating factor receptor activation in rat isolated lung tissue.
This study looked at the effects of platelet-activating factor (PAF) on rat isolated lung strips and tracheal spirals. Previous studies have shown that PAF induces hyperresponsiveness to the contractile effects of acetyicholine (ACh) and 5- hydroxytryptamine (5-HT) in rat isolated tracheal spirals. …
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Signalling Molecule Production by Escherichia coli and Campylobacter jejuni
Quorum sensing (QS) is a density-dependent gene regulation signalling mechanism utilized by bacteria to enable the simultaneous expression of bacterial phenotypes in a given population. Several QS mechanisms and different classes of signalling molecules, including acyl-homoserine lactones (AHLs), …
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In Vitro Chromosomal Radiosensitivity and Cell Cycle Progression in Cancer Survivors
The in vitro 02 chromosomal radiosensitivity assay is a technique used to investigate variation in the cellular response to radiation. In brief, lymphocytes are irradiated in the 02 phase of the cell cycle to induce DNA damage, which is exhibited at the subsequent metaphase as chromatid gaps and …
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Evaluating the Fungistatic and Fungicidal Activities of Bianthrones as Synthetic Intermediates to Novel Hypericin Analogues.
There is increasing demand for new and improved antifungal agents due to an increase in fungal infections and diseases in patients being resistant to previous antifungals. The focus of this research is on the synthesis of anthraquinone, anthrone, bianthrone and hypericin type derivatives and the …
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Effects of heat shock, hypoxia, post-mortem interval and glioma disease state on heat shock gene HSPA expression
Heat shock protein 70 (HSPA/HSP70) gene expression is induced by a wide range of cellular stress conditions. This study investigated HSPA/HSP70 expression in human cell lines exposed to hypoxic conditions, in cancerous and non-cancerous brain tissue specimens from 18 patients (gliomas and normal …
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The integration of an avirulent legionella pneumophilla into aquatic biofilms
A continuous culture model system was set up in the laboratory and inoculated with a diverse range of microorganisms, including several bacteria and protozoa, obtained from the local mains water tap supply. This inoculum and was added to the system without any prior culture or other selection …
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Hsp90 as a molecular target
Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, has been proposed to play a vital role in tumorigenesis. Hsp90 has two isoforms, of which Hsp90α is the major isoform of the Hsp90 complex and has an inducible expression profile. The molecular chaperone Hsp90α has been …
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Single Nucleotide Polymorphisms:Characterisation and Application to Profiling of Degraded DNA
Single nucleotide polymorphisms (SNPs) are one of the forensic markers used to resolve the problem of DNA typing from degraded samples. It has been found in previous studies that when profiling heavily degraded forensic samples the small amplicon required for SNP analysis has an advantage over the …