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Showing 1 to 20 of 20 for “"C21"”.
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Towards the Total Synthesis of Antascomicin B. Efforts to Construct the C1-C21 Fragment
<p>Antascomicin B is a macrolide isolated from a strain of <em>Micromonospora</em>. It possesses structural similarities to FK506 and rapamycin and exhibits potent binding ability to FKBP12. Recent reports suggest that small molecule ligands of FKBP12 possess potent neuroprotective and …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… angiotensin-II type 2 receptor (AT2R) agonist C21 rescues megalin surface expression in the proximal tubules potentially by activating Akt-mediated phosphorylation and inactivation of GSK3β in the kidney of male obese Zucker rats fed HSD for 48 hrs. The HSD intake resulted in proteinuria, which …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… to test whether the DREADD agonist, Compound 21 (C21), affected recognition memory assessed by NOR or, associative memory assessed by the Object-in-Place (OiP) test. I also investigated whether DREADD-mediated inhibition of parvalbumin (PV+) gamma-amino butyric acid (GABA)ergic interneurons of the …
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
… of a potent PRMT1-selective inhibitor, denoted C21. As C21 is able to covalently modify PRMT1, fluorescent and biotinylated C21 derivatives have been used as activity-based protein profiling probes for the elucidation of PRMT1 in vivo function.</p>
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Absorptionsspektroskopie von langen Kohlenstoff-Kettenmolekülen und deren Oxide in kryogenen Matrizen
… mit ungerader Atomzahl C17, C19, C21 und C23 werden mit der Methode der Absorptionsspektroskopie in kryogenen Matrizen untersucht. Die Absorptionen dieser Spezies im sichtbaren Bereich sind bekannt. Durch die Methode der Laser-induzierten Oxidation in sauerstoffhaltigen Matrizen …
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Efforts towards the Total Synthesis of Azaspiracid-3
… the total synthesis of azaspiracid-3.The C1-C21 domain and C22-C40 domain have been synthesized, which aims to assemble the molecule through Yamaguchi esterification. The ABCD domain involved an efficient NHK coupling reaction between C1-C12 segment and C13-C22 segment. The trioxadispiroketal …
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Studies on the total synthesis of gambierol via endo-selective epoxide-opening cascades
… precursors were subsequently prepared from C21 ketone. Investigation of a variety of methods for the C21-0 bond construction revealed a remarkably general spiroketalization pathway, which was previously unprecedented in ladder polyether synthesis and invariably led to the isolation of …
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Mechanistic investigation of the interrupted Bischler-Napieralski reaction and its application to the total synthesis of the aspidosperma alkaloids
… amide activation of a readily available C21-oxygenated lactam, followed by transannular cyclization and in situ trapping of a transiently formed C19-iminium ion, expediently provides access to the hexacyclic C19-hemiaminal ether alkaloids (+)- fendleridine, (+)-acetylaspidoalbidine, and …
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Genetics of seedling stage low temperature tolerance of rice
… for two BC1F5 populations derived from BR28*2/C21 and BR29*2/C21 challenged with 9°C for 14 days at the 3 leaf stage, where BR28 (BRRI dhan28) and BR29 (BRRI dhan29) are cold-sensitive indica mega-cultivars from Bangladesh, and C21 (C 21::IRGC 331-C1) is a cold-tolerant japonica cultivar. SNP …
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The Quantitative Determination of 3-7-Hydroxycorticosterone
… reaction is not given by any other member of the C21 corticosteroids: cortisone acetate (Comp. 1 ); 11-desoxy-17-hydroxy-corticosterone acetate; 11-dehydrocorticosterone acetate; desoxycortisone; 21-desoxycortisone; allopregnanediol- 3 (alpha), 20(alpha) ; allopregnanedione-3,20 (7). It was the …
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Studies towards the total synthesis of Antascomicin A.
… investigations into the formation of the C21-C22 trans double bond. Two successful approaches to the key coupling of the Cw-C16 aldehyde with the C1rC24 vinyl iodide to form the C10-C24 allylic alcohol are detailed, and the subsequent synthesis of the protected C10-C24 fragment is …
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Studies towards the total synthesis of madeirolide A
… an emphasis on the construction of the all-cis C21 – C27 eastern tetrahydropyran. [Figure] Chapters 1 and 2 provide an introduction to the importance of natural products in drug discovery and outline the context of this project with details of the isolation and biological activity of madeirolide …
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Metabolic Profiling of Genetically Modified Potato Periderm Tissues
… Phenolic acids, glycoalkaloids, alkanes (C21, C23, C25, C27, C29) and fatty acids (C16:0, C18:0, C18:2) were down-regulated in FHT-RNAi native periderms. For the solid interfacial residue, the FHT-RNAi variety displayed higher arene-to-(CH2)n and oxygenated alkoxy-to-(CH2)n ratios compared …
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Microwave-assisted pyrolysis of HDPE using an activated carbon bed
… the liquid transport fuels petrol and diesel (C5–C21). The non-condensable gases that resulted were short-chain aliphatics that could be used as feedstock for the creation of new chemicals (such as virgin HDPE), or fuels such as natural gas and LPG. The development of apparatus capable of adding …
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Machine Learning for Causal Estimation
… credible, data-driven causal claims. JEL: C14, C21, C45
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ORIGINS AND SHORT-TERM SEDIMENTARY FATE OF GLOBALLY DISTRIBUTED BIOLOGICAL MARKER HYDROCARBONS
… have been established. The assignment of C21, C22 and C26 homologues and other C20 and C25 isomers, remains tentative. A wide body of evidence suggests that the compounds are biogenic in origin, with algae and possibly bacteria the most likely source organisms. A few of the compounds have …
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Essays on the functioning of housing and labor markets
… R31, R32, R38 Chapter 3 JEL. Classification: C21, C31, C33, C36, J30.
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AN ASSESSMENT OF POSSIBLE TRENDS OF FUTURE CHANGES IN CONSTRUCTION PROCUREMENT ARRANGEMENTS IN SINGAPORE
… Specifically, the landmark report in Singapore "C21" identified the application of PPAs as one strategic thrust through which productivity of the industry would be enhanced. The approach of this research aimed to forecast the use trends as well as trends of the overall practice of PPAs in the …
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Characterisation and environmental effects of unresolved complex mixtures of hydrocarbons
… the presence of monocarboxylic acids (Cl - C21; 58%) and alicyclic carboxylic acids (C7 - C19; 16%), a hydrogenated monoaromatic sample contained monocarboxylic acids (Cl - C20; 30%), dicarboxylic acids (C2 - C11,7%) and alicyclic carboxylic acids (C7 - C18; 11%) , whilst a diaromatic …
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Development of a Kinetic Model for Low Temperature Fischer-Tropsch Synthesis
… that the favourable selectivity to wax products (C21+) in FT synthesis is adequately captured. The predictions of the single- and two-phase simulations were assessed by comparison to the wax product from LTFT reactors in Sasol processes. Both simulations were found to be useful in describing these …