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Showing 1 to 1 of 1 for “"C2'-deoxyamphotericin B"”.
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Electronic tuning of site selectivity and semisynthesis of C2'-deoxyamphotericin B
… be involved in the AmB-sterol binding event. The C2’ hydroxyl group has been implicated in a potential hydrogen-bond interaction with the sterol. Electronic tuning of site-selective acylation reactions was developed towards the synthesis of a C2’-deoxyAmB derivative. More electron-rich acyl donors …