Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"C1 domain"”.
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… inactivate these GTPases; in addition to a GAP domain, the a-chimaerins share a phosphokinase C (PKC)-like C1 domain but have distinct N-terminal domains (NTDs). My project has explored the importance of specific domains of a1-chimaerin both in induction of a morphological cellular protrusion …
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Allosteric Determinants of Guanine Nucleotide Binding Proteins and Methods to Crystallize the Cytosolic Domains of Adenylyl Cyclase
The cytosolic domains of mammalian adenylyl cyclases, termed C1 and C2, are responsible for catalytic activity and most regulatory properties. Crystal structures of the soluble catalytic core of adenylyl cyclase bound to activators Gsa and forskolin were previously determined. However, structural …
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Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues
… in cell membranes is limited. Using the C1 domain from mammalian PKCδ and PKD, we monitored the localization of yeast cytosolic-facing pools of DAG for the very first time and investigated alteration in distribution in response to conditions where DAG levels were known to be altered. Two …
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Inactivation of Stac3 causes skeletal muscle defects and perinatal death in mice
The Src homology 3 domain (SH3) and cysteine rich domain (C1) 3 (Stac3) gene is a novel gene copiously expressed in skeletal muscle. The objective of this research was to determine the role of Stac3 in development, specifically in skeletal muscle. We achieved this objective by evaluating the …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… been shown to be mediated through the regulatory domain and independently of the catalytic activity of PKCε. Here we identify residues located in the base of the C1b domain important for the neurite-inducing effect of PKCε. We have in an approach to elucidate the mechanisms that mediate …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
… of the enzymes and the isolated regulatory domain (RD) of PKCq induces apoptosis in neuroblastoma cells. Induction of apoptosis depends on the localisation of PKCqRD to the Golgi complex, which is mediated by the C1b domain of the protein. Mutation of a single amino acid residue, Met-267 in …