Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"C.elegans"”.
-
C.elegans locomotion: an integrated approach
he popular model organism Caenorhabditis elegans is a tiny nematode worm with a largely invariant nervous system, consisting of exactly 302 neurons with known connectivity. Moreover, the behavioural roles of many of these neurons have been uncovered using experimental techniques including targeted …
-
Mechanisms for Maintaining Cell Identity in C.elegans Olfactory Neurons
… AWCON and AWCOFF, in the nematode Caenorhabditis elegans. The AWCON and AWCOFF identities are specified by a stochastic decision during embryogenesis, but several of the genes involved in this embryonic decision are subsequently downregulated. Additional mechanisms must therefore act to maintain …
-
Microfluidic Devices for Neural and Behavioral Screening of C.Elegans using Electric Field
C. elegans is an invaluable model for studying human diseases, from understanding disease pathology to screening for chemicals toxicity and therapeutic effects. However, technological deficiencies in achieving automated, fast, simple, and low-cost C. elegans-based screening assays have hindered the …
-
Microfluidics for Calcium Imaging of C.elegans Neurons During Temporally Precise Odor Stimulation
… for high-throughput calcium imaging in C.elegans. I used the nematode worm, C.elegans as a model system for several reasons: (1) odor-evoked responses have been well characterized, both at the neural and behavioral level1, (2) scientists have mapped out all of the 302 neurons and …
-
Genetic and molecular analysis of the C.elegans cell survival gene ced-9
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
-
Development of computational and experimental tools to study mechanotransduction in C.elegans and primates
… in two model organisms, namely the nematode C.elegans and the primate Rhesus macaque, each presenting its own advantages. Due to the physiological similarity of their anatomy and readily available mechanoreceptor neurophysiological data, primates are a popular model organism used to study the …
-
Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
<p>Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering cell-specific activation of the cell death machinery remain, for the most …
-
Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation
… function in cell proliferation, using the <em>C. elegans</em> germ line as an <em>in vivo</em> model. BEC-1 is the <em>C. elegans</em> ortholog of human BECN1/Beclin 1, an essential autophagy regulator and tumor suppressor protein. We show that basal levels of autophagy are required for germline …
-
Towards the neurocomputer: an investigation of VHDL neuron models
… through simulations of the Caenorhabditis Elegans (C.Elegans) locomotory system. The C.Elegans system is synthesized into hardware showing a massive improvement in simulation time because the hardware design runs in real-time, meaning a 19 second simulation takes 19 seconds vs. the 1.5 …
-
Transposable elements: What have you done for me lately? A genomics based investigation into the potential functional roles of transposable elements using the model organism Caenorhabditis elegans
… 276 full length and partial elements in the C.elegans genome. I determined the genomic location of each and looked for patterns resulting from their presence. I found that they are widespread throughout the C.elegans genome, and do not cluster on the arms of the chromosomes as was previously …
-
The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… to characterize the anaerobic metabolism of C. elegans, a roundworm closely related to a large class of parasitic worms, by combining systematic metabolomics with a structural biology approach in order to find selective drug targets. Fumarate reduction has been previously identified as the …
-
Einfluss von Kalorienrestriktion auf den Metabolismus
… zu können, nutzen wir den Modellorganismus C.elegans. Eine kontinuierliche Restriktion wirkte sich verlängernd, eine Überversorgung verkürzend auf die Lebensspanne des Rundwurms aus. Der Einfluss eines zeitlich eingeschränkten, intermittierenden Nahrungsregimes, analog zum Weight-Cycling im …
-
Developing a Caenorhabditis elegans Model for Marfan Syndrome
… objective of this study was to establish a C.elegans MFS model and use this model to determine which genes interact with a C.elegans fbn1 homolog, MUA-3 and ascertain the role of metabolic rate in the development of MFS pathology. We isolated a temperature sensitive mutant of mua-3, a fbn1 …
-
A recombineering pipeline for functional genomics applied to Caenorhabditis elegans
… approach for the model nematode Caenorhabditis elegans. The method is based on recombination mediated DNA engineering of genomic BAC clones into tagged transgenes for integrative transformation. C.elegans offers unique advantages for function discovery through protein tagging: compact and a well …
-
Cloning and characterization of exc-9, a Caenorhabditis elegans CRIP homologue that regulates tubular structure
… development. The excretory canal cell of C.elegans forms a single-cell epithelial tubule, which provides a simple model for tubular structure study. The EXC proteins regulate maintenance of the apical (lumenal) cytoskeleton of the excretory canal. Loss of exc gene function allows formation …
-
The Effects of Treating Dauer C. Elegans with Natural Anthelmintics and Ivermectin
… focused on two strains of Caenorhabditis elegans, a wild and mutant strain. They were split into a dauer and non-dauer group and further divided into different samples. Dauer and hypobiosis are both stages of arrested development that is triggered by stressful circumstances. The worms will …
-
Effects of Zinc Oxide Nanoparticles on the Pharyngeal Pumping and Neurological Behavior of C. elegans
… behaviors of the nematode Caenorhabditis elegans (C. elegans). While several studies have examined endpoints regarding behavior, reproduction efficacy, lethality and transgene expression after exposure to ZnO - NPs, insufficient attention has been allocated to the effects of the ZnO - NPs …
-
Discovering Conserved cis-Regulatory Elements That Regulate Expression in Caenorhabditis elegans
… regions surrounding every gene in <italic>C.elegans</italic>: i.e. the regulome) and: 2) to determine which cis-regulatory elements are associated with expression under specific conditions. We initially use PhyloNet to predict conserved motifs with instances in about half of the …
-
Two C. elegans high mobility group genes, hmg-12 and hmg-1.1, function in neural postembryonic development and cell survival
… dieser Studie wurden die Funktionen von zwei C.elegans HMG Proteinen, HMG-12, das zu den HMGI(Y)Proteinen gehört und HMG-1.1, das zur HMG1/2-Familie gehört, untersucht.Die Verringerung von HMG-12 mittels RNAi führte zu neuronalen Defekten in adulten Tieren. Die hmg-12 RNAi Tiere waren …
Page 1 of 2