Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"C.albicans"”.
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Vergleichende Analyse zwischen Candida albicans und Candida dubliniensis unter besonderer Berücksichtigung des Transkriptionsfaktors Rim101
… kann, wie auch die nahe verwandte Spezies C.albicans, als Antwort auf eine Reihe von Umweltfaktoren von der Hefeform in echtes filamentöses Wachstum übergehen. Bei der Regulation des pH-abhängigen Dimorphismus von C.dubliniensis spielt, wie bei verschiedenen anderen Pilzspezies der …
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Analysis of Nitrogen starvation induced filamentous growth and characterization of putative essential genes in the human fungal pathogen, Candida albicans
1. Zusammenfassung Candida albicans ist ein opportunistisch pathogener Hefepilz, der sowohl oberflächliche Infektionen der Schleimhaut als auch lebensbedrohliche systemische Infektionen hervorrufen kann. Obwohl die Fähigkeit von C.albicans Infektionen auszulösen weitgehend vom Immunstatus des Wirts …
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A bioactive peptide from the skin secretion of the Chinese Torrent Frog, Amolops wuyiensis
… bacterium E.coli and pathogenic yeast C.albicans. Thus, QUB-1402 could expand the potential drug discovery and development pipeline directed towards alleviation of serine protease-mediated pathologies.<br/>
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QUB-1383, a novel bioactive peptide from the defensive skin secretion of the edible frog (Pelophylax kl. esculentus)
… potent antimicrobial activity against C.albicans, S. aureus and E. coli with minimal inhibitory concentrations at 4 μM, 2 μM and 16 μM, respectively. However, it also displayed relatively strong haemolytic activity with EC50 value at 39.64 μM. QUB-1383 also exerted weak inhibitory effect …
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Identification, isolation and bioactivity assessment of a bioactive peptide QUB-1465 from the skin secretion of Hylarana guentheri
… 10788）with MIC of 8 µM and MBC of 16 µM, and C.albicans (ATCC 10231) with MIC of 32 µM and MBC of 64 µM respectively. Also, its haemolytic activity was low with HC50 of 1.888mM. So QUB-1465 is promising antibacterial drug candidate.
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
… S.aureus (MIC = 4 µmol/L), and the yeast C.albicans (MIC = 64 µmol/L). The QUB-2577 was also found to exhibit anticancer activity against U251-MG, H157, PC-3 cell lines at the concentration of 10-4 M, but the anticancer effect of the peptide decreased dramatically when the concentration was …
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QUB-1157: a bioactive peptide from the skin secretion of the Mexican leaf frog (Pachymedusa dacnicolor)
… to have any antimicrobial activity against C.albicans, E.coli and S.aureus. QUB-1157 also had no cytotoxicity on horse erythrocytes. However, QUB-1157 inhibited the proliferation of cancer cell line H-157 and U251MG. All these data indicate that it is probably necessary to research more about …
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Studies on a bioactive peptide QUB-2044 from the skin secretion of the Chinese frog, Odorrana schmackeri
… a relatively moderate one against E.coli and C.albicans with the MIC values being 16 μM, 32 μM and 32 μM, respectively, and showed mild cytotoxicity against red blood cells at these concentrations. However, the peptide did not show significant anti-cancer activity.
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A novel bioactive peptide from the skin secretion of Hylarana nigrovittata
… micro-organism models (E.coli, S.aureus, and C.albicans). Moreover QUB-1704 showed no haemolytic activity against horse blood cells. It showed anticancer activity against H23 cell line at the concentration of 10-4 M. In addition, QUB-1704 showed trypsin inhibitory activity and the Ki was …
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Discovery and functional evaluation of a host defense peptide from Rana amurensis
… this peptide had less potency against C.albicans (MIC=512μM), along with low haemolytic activity (HC50< 512 μM). Also, peptide QUB-2566 had a weak antiproliferative effect on lung cancer cells H838. Altogether, this peptide may become a lead compound for new antimicrobial drug development …
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The discovery of a novel peptide, QUB-2274, from the defensive skin secretion of Rana amurensis
… Gram-negative bacterium E.coli, and the yeast C.albicans, but with a high haemolytic activity. It also had a strong anti-proliferative effect on the four tested human cancer cell lines: PC-3, NCI-H157, MDA-MB-435S and U251MG.<br/><br/>These studies on QUB-2274, have provided the basic data for …
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Identification, isolation and bioactivity assessment of a bioactive peptide QUB-2339 from the skin secretion of the Hainan sucker frog, Amolops hainanensis
… activity against E.coli (CRM8739) and C.albicans (ATCC10231) even at the concentration of 512 μM. Furthermore, QUB-2339 also had anti-cancer activity at 100 μM against lung cancer cell line (NCI-H838). However, the haemolytic rate of QUB-2339 was relatively high, which was more than 10%, …
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Assessing bioactivity of a peptide from the skin secretion of Rana amurensis
… was failed to inhibit the growth of E.coli and C.albicans. Also, QUB1301 was found to have low haemolytic activity at the concentration up to 512 μM. The growth of four cancer cell lines (U251MG, H157, PC3 and MB435S) was not inhibited by the peptide which means that QUB1301 possesses no obvious …
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Identification and functional study of a novel antimicrobial peptide, QUB-2014, from the skin secretion of the frog, Phyllomedusa tomopterna
… (ATCC CRM 8739), S.aureus (ATCC CRM 6538) and C.albicans (ATCC CRM 10231) with minimum inhibitory concentrations of 16 μM, 4 μM and 32 μM, respectively. This peptide also showed anticancer cell proliferative activity on lung adenocarcinoma cells at a concentration of 10-4 M. On the other hand, …
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Identification, isolation and bioactivity assessment of a novel peptide from the skin secretion of the Tiger-striped Leaf Frog (Phyllomedusa tomopterna)
… activities towards E. coli, S.aureus, and C.albicans. The MICs were 8 μM, 4 μM, and 32 μM. QUB-2982 also inhibited the growth of three kinds of human cancer cells: U251MG, PC-3, and H157. At the concentration of 10-4 μM, the cancer cell viabilities were 0.33 %, 1.33 %, and 3.33 %, …
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LPS, A TLR-4 AGONIST AND VIPER A TLR-4 INHIBITOR UPREGULATE PHAGOCYTOSIS OF ZYMOSAN IN BV2 CELLS
… to AD, specifically in relation to <em>Candida albicans (C.albicans)</em>. Thus, understanding the mechanism of fungal clearance in the CNS is of importance. The main pathogen-associated molecular pattern (PAMP) for <em>Candida</em> is its fungal cell wall, which consists of structural …
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The discovery of the novel peptide QUB-2049 from the skin secretion of Odorrana versabilis
… ATCC CRM 6538) ((MIC = 64 μM), and Candida albicans (C.albicans ATCC CRM 10231) (MIC = 128 μM). In the haemolysis assay peptide QUB-2049 showed an obvious haemolytic activity (% haemolysis >10) at concentrations ≥16 μM. The result of the antiproliferative assay showed that QUB-2049 had …
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The Development and Evaluation of a Range of Phototherapeutic Dyes Towards Infection Control
… by testing the compounds in vitro against C.albicans, with only four compounds showed antimicrobial activity. The 5,10,15,20-Tetrakis-(4-hydroxyphenyl)-21H,23H-porphine was the only porphyrin to show moderate growth inhibition when illuminated with blue light for 20 minutes. All the hydroxy …
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Isolation of ovine hemoglobin, its apoglobins and peptides, for the determination of antimicrobial activities : a thesis presented in partial fulfilment of the requirements for the degree of masterate of Engineering in Biotechnology at Massey University, Palmerston North, New Zealand
… digest fractions against S.aureus and C.albicans, six candidates were selected for mass spectroscopy and MIC (Minimum Inhibitory Concentration) testing based on their potency and reproducibility in RP-HPLC. Most of the peptides within these complex fractions were largely small random …
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Identifizierung und Charakterisierung eines neuen Zielgenes des Transkriptionsfaktors ASH1 & Charakterisierung des Candida albicans ASH1 in Saccharomyces cerevisiae
… Pilze wie Saccharomyces cerevisiae und Candida albicans dar. Im Rahmen dieser Arbeit konnte ich zeigen, daß das C. albicans ASH1-Homolog (CaASH1) in S.cerevisiae auf Grund der Lokalisation der CaASH1 mRNA in die Tochterzelle ebenfalls eine asymmetrische Verteilung des CaAsh1 Proteins vorweist. …