Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 472 for “"C. elegans"”.
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Serotonin signaling in C. elegans
Wild-type animals that have been acutely food deprived slow their locomotory rate upon encountering bacteria more than do well-fed animals. This behavior, called the enhanced slowing response, is partly serotonin (5-HT) dependent. Animals mutant for the 5-HT reuptake transporter gene mod-5 slow …
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Tools for connectomics in C. elegans
… the 302-node nervous system of the nematode C. elegans and its transparency have made it an attractive model organism in neuroscience for several decades. Indeed, Caenorhabditis elegans has long been touted as the only species for which the connectome is known, reconstructed by hand from …
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Tools for Behavioral Phenotyping of C. elegans
… behavior and the brain is the nematode C. elegans. However, current phenotyping tools have technical limitations that make observing, intervening in, and quantifying behavior in diverse settings difficult. In this thesis, I develop enabling technological systems to resolve these challenges. …
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Analysis of Zinc Transporters in C. elegans
… To address these questions, we used C. elegans as a model system. While three C. elegans cdf genes have been characterized previously, the majority of zinc transporters remain to be studied. Here, we characterized cdf-2 and ttm-1 and conducted initial studies of other zinc transporters. …
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Autophagy and Lipid Homeostasis in C. elegans
… lipid storage and breakdown. The nematode C. elegans is an ideal model to address the fundamental mechanisms that underlie lipid homeostasis in an intact organism. We discovered that autophagy gene activity (unc-51/ULK1/2, bec-1/BECN1, vps-34/VPS34, and lgg-1/LC3I) is required for neutral …
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Familiar Food-Induced Feeding Activation in C. Elegans
… conservation of feeding regulators make C. elegans an attractive model system for the study. Food intake in C. elegans requires two muscle motions, pharyngeal pumping and isthmus peristalsis, and the frequencies of the two feeding motions dramatically increase in response to food as in other …
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Validating ngn-1 transcriptome targets in C. elegans
… characterized. The nematode <em>Caenorhabditis elegans</em> contains a single <em>ngn-1</em>/neurogenin ortholog. <em>ngn-1(ok2200) </em>null mutants show multiple neurological phenotypes, including axon outgrowth defects and embryonic lethality. Previous work in our lab performed RNAseq …
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Regulation of cell-identity maintenance in C. elegans
… I describe genetic analyses of the nematode C. elegans that have provided insights into a mechanism that cells utilize to regulate gene expression and in turn maintain the identities of terminally differentiated cell types. ctbp-1 is the sole worm ortholog of the C-terminal Binding Protein …
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Neural Sequences Underlying Directed Turning in C. elegans
… architecture of neural circuits that control C. elegans olfactory navigation. We identify error-correcting turns during navigation and use whole-brain calcium imaging and cell-specific perturbations to determine their neural underpinnings. These turns occur as motor sequences accompanied by …
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Control of sex myoblast migration in C. elegans
… manipulations, the use of the nematode C. elegans as a model system has greatly advanced our understanding of mechanisms governing cell migration conserved through higher organisms. Among several migration processes in C. elegans, sex myoblast (SM) migration is an attractive system that has …
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A link between c. Elegans morphogenesis and mrna export
… governing development of the Caenorhabditis elegans pharynx. In this study we used whole genome sequencing (WGS) and CloudMap/Hawaiian Variant Mapping to specifically map a mutation that produced a Pun pharynx (unattached pharynx) phenotype. We discovered a thermo-sensitive t2160 mutant …
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The Neural Circuitry Of Social Behavior In C. elegans
… in neurobiology. I used the nematode C. elegans as a model system to study the genetics and neural circuitry that underlie social behavior. First, I evaluated the behavioral responses of C. elegans to a nematode extract (deathmone), which served as a model for alarm pheromones in other …
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Large-scale transgenesis and nerve regeneration in C. elegans
Caenorhabditis elegans (C. elegans) is a widely studied model organism due to their fully mapped neural network of 302 neurons and amenable genetics. Their small size and short life cycle allows for rapid studies to be conducted; however, after decades of use the manual methods of manipulation have …
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Functional analysis of the microRNA genes of C. elegans
MicroRNAs (miRNAs) were discovered in C. elegans during studies of the control of developmental timing. MicroRNAs are a large class of short non-coding RNAs found in many viruses, plants and animals that regulate gene expression through sequence-specific base-pairing with target mRNAs. Initial …
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Genetic and molecular analysis of C. elegans vulval invagination
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… death via unclear mechanisms. In the nematode C. elegans, I developed a model to study cellular degeneration in response to mechanical stress caused by blunt force trauma. I identified a dual-specificity MAPK phosphatase, VHP-1, as a stress-inducible modulator of neurodegeneration. VHP-1 regulates …
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The Long-Rage Directional Behavior of the Nematode C. Elegans
<p>Like any mobile organism, C. elegans relies on sensory cues to find food. In the absence of such cues, animals might display defined search patterns or other stereotyped behavior. The motion of C. elegans has previously been characterized as a sinusoid whose direction can be modulated by gradual …
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A New Type of Programmed Cell Death in C. Elegans
… regulated PCD of the Caenorhabditis elegans linker cell. We have carried out transmission electron microscopy studies of dying linker cells, which revealed non-apoptotic features, including nuclear crenellation in the absence of chromatin condensation, swelling of mitochondria and …
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Sensory and Neuromodulatory Entrainment of Foraging States in C. Elegans
… environment. In the nematode Caenorhabditis. elegans, foraging animals alternate between states of locomotory arousal. I observed that animals in low activity states remain nearby food patches, whereas highly aroused animals often exit patches to explore the external environment. Using …
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