Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"C-type lectins"”.
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Biophysical Studies of Pathogen Recognition by C-Type Lectins
C-type lectins are a prominent class of pathogen recognition receptors in the innate immune system. The three pathogen recognition lectins studied in this thesis are the mannose binding protein (MBP), the dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) and the dendritic cell-specific …
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… This screen revealed that expression of two C-type lectins, RegIIIbeta and RegIIIgamma , is strongly induced following intestinal colonization with resident microbes. Two features suggested that members of the RegIII family may have microbicidal functions. First, they are C-type lectin family …
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The effect of two novel C-type lectins, Ba100 and Ba25, isolated from the venom of the puff adder, Bitis arietans on T lymphocyte proliferative responses
Includes abstract. Includes bibliographical references (p. 233-318).
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Molecular Basis of Peptidoglycan Recognition by a Bactericidal Gut Lectin
… RegIII proteins are novel in that they are C-type lectins that directly kill Gram-positive bacteria and thus play a vital role in antimicrobial protection of the mammalian gut. RegIII proteins bind their bacterial targets via interactions with cell wall peptidoglycan, but lack the canonical …
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Biologically Inspired Engineering for Protein Stabilisation
… durable proteins are known to belong to the C-type lectin-like protein family. It is thought that at least one C-type lectin-like protein is found in the eggshells of every species. The most well known C-type lectin-like protein is the OC-17 from chicken eggshell. OC-17 and other C-type lectins …
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Direct detection of homocysteine and syntheses of lanthanide complexes as biosensors
… recognition of saccharides by C-type lectins, a water-soluble salophene-lanthanum complex was synthesized. It can be used in the detection of neutral sugars at physiological pH. Anionic sugar detection is also of importance to biomedical research. For instance, an increase or …
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Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal
… peptides, reactive oxygen species, and C-type lectins. Some down-regulation of transcription during primary infestation was indicated. During secondary infestations, these responses intensified and more cell types infiltrated the bite site. A Th2-type response was suggested for D. …
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SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
C-type lectin receptors (CLRs) are calcium-dependent proteins dedicated to sensing glycan motifs, including those expressed on the surface of invading pathogens. Although this recognition event usually leads to induction of an immune response, many pathogens have evolved mechanisms to exploit …
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Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model
… molecules such as cytokines, chemokines and type I IFNs. MPI macrophages are susceptible to IAV infection but this results abortive replication, following established understandings. However, MPI macrophages are much more sensitive to influenza infection than non-AM models, resulting in a …