Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"C-type lectin"”.
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SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
C-type lectin receptors (CLRs) are calcium-dependent proteins dedicated to sensing glycan motifs, including those expressed on the surface of invading pathogens. Although this recognition event usually leads to induction of an immune response, many pathogens have evolved mechanisms to exploit …
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The functional characterisation of the C-type lectin : Clecsf8
Clecsf8 is a poorly characterised member of the "Dectin-2 cluster" and was originally thought to be expressed exclusively by macrophages. In this study it was demonstrated that Clecsf8 is primarily expressed by peripheral blood neutrophils and monocytes.
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The characterization of a novel C-type lectin-like receptor, CLEC9A
Includes abstract. Includes bibliographical references (leaves 147-161).
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… was recently shown to negatively regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal pathogens. The aim of this thesis was to firstly develop a cell line model system to investigate the mechanism by which tetraspanins inhibit dectin-1, and …
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Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… in immune-compromised individuals. Dectin-2, a C-type lectin receptor, is required for recognition of <em>C. albicans </em>by innate immune cells and is required for initiation of the anti-fungal immune response. We set out to identify components of the intracellular signaling cascade downstream …
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Biologically Inspired Engineering for Protein Stabilisation
… durable proteins are known to belong to the C-type lectin-like protein family. It is thought that at least one C-type lectin-like protein is found in the eggshells of every species. The most well known C-type lectin-like protein is the OC-17 from chicken eggshell. OC-17 and other C-type lectins …
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Tracing The Origin Of A Lectin-like Antifreeze Protein
Type II antifreeze proteins (AFPs) are C-type lectin homologs found in three lineages of teleost fish (Cottidae, Clupeiformes and Osmeriformes). Previous work demonstrated that the AFP gene was horizontally transferred from the Atlantic herring to the smelt, and also showed that the herring is not …
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Maternal β-Glucosylceramides Alter Neonate Hematopoiesis and Lung Microbiota
… are known to signal through a C-type lectin receptor called Mincle. In addition, lung microbial dysbiosis is associated with development of allergic asthma in children. Here we show that maternal β-Glucosylceramides alter hematopoiesis in the neonate by signaling through Mincle in …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… and maintain vascular integrity. CLEC-2 is a C-type lectin-like receptor that is highly expressed in platelets and lesser extent, in other cell types such as activated dendritic cells and B cells. Rhodocytin was the first ligand used to identify CLEC-2 receptor and it’s signaling on platelets. …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… work defined the contribution of Mincle, a C-type lectin receptor (CLR), in innate immunity to O. tsutsugamushi. Following lethal infection in C57BL/6 mice, pulmonary differential expression analysis revealed Mincle (Clec4e) among the top 5 greatest up-regulated genes, accompanied with CLR …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… work defined the contribution of Mincle, a C-type lectin receptor (CLR), in innate immunity to O. tsutsugamushi. Following lethal infection in C57BL/6 mice, pulmonary differential expression analysis revealed Mincle (Clec4e) among the top 5 greatest up-regulated genes, accompanied with CLR …
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Monocyte Derived Dendritic Cells: Sentinels and Translators of Immune Response to Staphylococcus aureus
… We further elucidated the role of DC DEC205, a C-type lectin, in <i>S. aureus</i> uptake. Blocking of receptor mediated endocytosis resulted in reduced uptake of <i>S. aureus</i> by DC. Confocal microscopy confirmed a role for DEC205 in <i>S. aureus</i> internalization and delivery to endosomes. …
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… This screen revealed that expression of two C-type lectins, RegIIIbeta and RegIIIgamma , is strongly induced following intestinal colonization with resident microbes. Two features suggested that members of the RegIII family may have microbicidal functions. First, they are C-type lectin family …
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Intrahost evolution of HIV-1 phenotypes
… in trans-infection ability, mediated by the C-type lectin DC-SIGN, at end-stage disease. In addition, end-stage R5 HIV-1 were more sensitivity to certain broadly neutralizing antibodies. Furthermore, phenotypic alterations correlated with the decline in CD4+ T cell count during development of …
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Synthesis of mannosylated peptides as components for synthetic vaccines
… Calcium dependent binding is specific for C type lectin receptor family that MRs belong to. Five remaining glycopeptides are currently undergoing biological evaluation.
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Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
… the surface of pathogenic fungi. Specifically, C-type lectin receptors (CLRs) have been shown to be the principal initiators of innate immune response during fungal infection. Limited studies have focused on the role of CLRs in Pneumocystis infection. Dectin1and Mincle have been shown to recognise …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… validated the array results. Chodl contains a C-type lectin domain representing a potential cell surface receptor for guidance factors. Gene knock-down experiments with two independent morpholinos led to stalling of CaP motor axons at the horizontal myoseptum, a pivotal choice point for axon …
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Pathogen-Specific Adaptations to Conserved Signaling Pathways in Cryptococcus neoformans
… members of both the Toll-like receptor and C-type lectin receptor families are involved in detecting strains with increased chitin exposure. Finally, in vivo immunological experiments demonstrated that the rim101Δ strain induced a global inflammatory immune response in infected mouse lungs, …
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