Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"C-di-GMP"”.
-
Régulation du c-di-GMP et rôle de ce messager secondaire dans la formation de pili de type IV chez Clostridium difficile.
Malgré la découverte du c-di-GMP en 1987, ce n’est que durant la dernière décennie que l’importance de ce messager secondaire dans la régulation des phénotypes bactériens a été exposée. Synthétisé par des diguanylate cyclases (DGC) et dégradé par des phosphodiestérases spécifiques (PDE), le …
-
Characterization of cyclic di-GMP binding by the sole Borrelia burgdorferi and Borrelia hermsii PilZ domain-containing proteins
… burgdorferi and Borrelia hermsii cause Lyme disease and relapsing fever, respectively. These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP has …
-
Cyclic-di-GMP Signaling in the Borrelia Spirochetes
<p>Lyme disease is the most common tick-borne disease in North America, with approximately 35,000 cases reported to the Centers for Disease Control in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of …
-
Cyclic di-GMP signalling and the regulation of virulence, biofilm formation and epiphytic fitness in the phytopathogen <i>Xanthomonas campestris</i>
… for its host plant is dependent on many different factors (Chan and Goodwin, 1999). A pivotal role is played by the second messenger cyclic di-GMP. C-di-GMP is essential for successful infection of the host not only by <i>Xcc</i> but also by many other pathogens. Roles for c-di-GMP …
-
Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate …
-
Function, localization and regulation of the Pseudomonas aeruginosa diguanylate cyclase response regulator WspR
WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of <italic>Pseudomonas aeruginosa</italic> on surfaces. Active WspR produces c-di-GMP, which in turn stimulates biofilm formation. Previous work demonstrated …
-
Single molecule studies of rna-target interactions
… other biophysical techniques to study how the folding of RNA allows it to perform its various functions by recognizing and binding a target ligand. We have shown that the c-di-GMP riboswitch undergoes a large, global conformational change upon binding of the ligand. The folding dynamics of the …
-
Structural studies on the biosynthesis and biological functions of natural products
… investigation of natural products include the dissecting of the biosynthesis pathways of these compounds and elucidating the biological processes affected by these compounds. These studies would facilitate the production of potential drugs through biosynthesis or semi-biosynthesis, and provide …
-
Elucidating the roles of the diguanylate cyclases CelR and avmA in attachment and cellulose synthesis with the response regulator divK in Agrobacterium tumefaciens
… tumefaciens, the causative agent of crown gall disease in plants, physically interacts with plant cells to remain anchored within the nutrient-rich rhizosphere. Part of this interaction involves the production of cellulose fibrils by the bacteria, leading to the aggregation of the cells to each …
-
REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… spent characterizing what could be seen with a rudimentary microscope. Today, knowledge of biofilms in vitro has grown substantially with modern technology; however, knowledge of biofilms in vivo is still lacking. By forming a biofilm, the bacterium increases its persistence and chances of …
-
Single-Molecule Studies Of Local And Global Nucleic-Acid Dynamics
… are important for their function. Structural studies have over the decades been invaluable in elucidation of various biomolecular mechanisms, hence contributing significantly to the understanding of biological events. However, a clear understanding of how molecules function in the cellular …
-
THE SUBTLE BIOFILM REGULATION IN ESCHERICHIA COLI: CSGD AND THE YDDV-DOS OPERON
… environment. The biofilm determinants studied in this thesis are all expressed in response to environmental conditions such as low temperature, low osmolarity and starvation, suggesting that E. coli bacteria switch to a biofilm mode of growth as part of their adaptation to the natural …
-
Comparative whole genome transcriptional responses of Ruminococcus albus strain 7 and 8: a case for specialization and niche differentiation
… in host nutrition. To better understanding of host-microbe interactions, it is relevant to establish the model for fiber degradation and vitamin metabolism of the dominant fibrolytic bacteria and investigate their roles in the gut ecosystem. However, the fibrolytic mechanism and vitamin …
-
Synthesis of Non-Natural Cyclic Di-Nucleotides for the Investigation of Bacterial Signaling Pathways
… the ability to communicate, albeit in more discreet, yet no less complex ways. Bacteria rely on an incredibly diverse signaling system of triggers and responses in order to survive and to thrive. While we perceive language with our eyes and ears, bacteria employ a system of small molecules …
-
Effect of Exopolysaccharides on Pseudomonas aeruginosa Physiology
… acids, and lipids. Biofilm matrix composition mediates how bacteria interact with one another and their environments. The biofilm matrix of the opportunistic pathogen P. aeruginosa contains up to three chemically distinct EPS: Pel, Psl, and alginate. EPS production is necessary for robust P. …
-
Effects of substrate stiffness on bacterial biofilm formation
… topography, and charge. However, few studies have been conducted to investigate the effects of substrate stiffness. In this study, Escherichia coli RP437 and Pseudomonas aeruginosa PAO1 were used as model strains to investigate the early stage biofilm formation on poly(dimethylsil-oxane) …
-
Mathematical Model of the Cell Cycle Control and Asymmetry Development in Caulobacter crescentus
Caulobacter crescentus goes through a classic dimorphic cell division cycle to adapt to the stringent environment and reduce intraspecific competition. Caulobacter mother cell gives rise to two progenies with distinct morphology - a motile swarmer cell equipped with a flagellum and a sessile …
-
Bacterial collectives
… highly integrated groups. These structures can display multicellular‑like features but typically do not reproduce as groups, and thus are not units of selection in a paradigmatic Lewontin-sense. In the framework of evolutionary transitions in individuality, such collectives must first emerge and …