Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 1 of 1 for “"C-degron"”.
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Systematic C-degron activity profiling implicates conditional regulation of the CTLH E3 ligase complex in ribosome maturation.
Many E3 ubiquitin ligases recognise specific degron motifs located at protein termini, yet the physiological relevance of these N-degron and C-degron pathways remains poorly understood due to the limited number of validated substrates. Thus, the major aim of this thesis was to define how C-terminal …