Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"C-RAF"”.
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Regulation of C-RAF stability by the RanBPM/CTLH complex
… the ERK1/2 pathway through the modulation of C-RAF protein levels. This study shows that RanBPM-mediated degradation of C-RAF occurs through the proteasome and the entire CRA domain of RanBPM is necessary for direct interaction with C-RAF and for effective downregulation of C-RAF in human cells. …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, the Raf protein family of …
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Kartierung krebsrelevanter Signalwege
… und Apoptose beteiligt. Proteinkinasen der Raf-Familie wirken dort als signalübertragende Elemente, welche Membranrezeptoren nachgeschaltet sind. Diese Proteine fungieren als Proto-Onkogene, eine Veränderung dieser Proteine kann sie in Onkogene überführen und sind wesentlich an der …
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Mouse Oocyte Maturation and Embryo Development After Exposure to Vemurafenib (PLX4032), an Anti-Melanoma B-RAF V600E Inhibitor
<p>Vemurafenib is a selective B-Raf<sup>V600E</sup> inhibitor in melanoma targeted therapy which also inhibits the wild type B- and C-Raf. In oocyte maturation, the C-Raf/MAPK pathway acts as an important self-enhancing and promoting system, w hereas in embryo development, the C-Raf/M APK pathway …
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Die Rolle der Serin/Threonin Kinase Cot in Proliferation, Differenzierung und Apoptose
… der Maus untersucht. Expression von onkogenem c-Raf-1 oder v-Mos führt zu einer Differenzierung in PC12-Zellen. Cot induziert ebenfalls Neuritenbildung in diesen Zellen. Ähnlich wie v-raf hat onkogenes cot eine antiapoptotische Wirkung auf 32D-Zellen nach IL-3-Entzug. In neugeborenen NSF/N-Mäusen …
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Identification of novel biomarkers for clinical prognosis in breast cancer
… of kinases and transcription factors e.g. c-RAF-1, ERK-1/2, AKT, LYN, SRC family kinases (SFKs) and NFκB (p50 RelA) were analysed in combination with SK1 and S1P receptors to discover novel prognostic interactions that drive cancer progression in ERα positive breast cancer patients. High …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… either inhibitor upregulated total Lyn and c-RafpS259, and increased associations between Lyn/c-Raf and cRaf/ERK. This was consistent with increased c-Raf C-terminus phosphorylation that may be regulated by ERK-propelled feedback signaling within a KSR1 scaffold. PP2 and dasatinib had …
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MEK1 binds βarrestin1 directly, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
… It functions as an adaptor protein in the c-Raf/MEK/ERK cascade by interacting with c-Raf and ERK. In this study, I have shown that (1) β-arrestin1 can bind MEK1 directly, mediated at least in part by D26D29 of β-arrestin1 and R47K48R49 of MEK1. (2) Disruption of this association by …
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Molekularbiologische Untersuchung intrazellulärer Signalwege, die in T-Lymphozyten zur Aktivierung des Transkriptionsfaktors NF-ATc führen
… Nachweis, daß konstitutiv aktive Mutanten von c-Raf und Rac synergistisch die CBP/p300-vermittelte TAD-A-Aktivierung verstärken, unterstreicht die wichtige Rolle, die CBP/p300 bei der Integration von T-Zell-Aktivierungssignalen spielt.
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
The RAF/MEK/MAP Kinase signal transduction cascade is the most extensively studied MAPK pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. The Ras effector and E3 ligase family member IMP (Impedes …
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Genomweite Suche neuer Modulatoren der Signaltransduktion in kardialer Hypertrophie und Herzinsuffizienz
… Arbeit konnte erstmals gezeigt werden, dass B-Raf in der Regulation kardialer Hypertrophie eine Rolle spielt. Um dies zu ermitteln, wurde im Modell kultivierter neonataler Kardiomyocyten der Ratte, die Zellgröße planimetrisch untersucht. Die Zellen wurden dabei mittels Phenylephrin zur …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… 3D collagen matrices. Pak2 and Pak4 activate two Raf kinases, B-raf and C-raf, to induce EC lumen formation. Further examination of Raf kinase signaling reveals that regulation of EC lumen formation in 3D collagen matrices depends on ERK signaling. This data reveals a coordinated kinase signaling …
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AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… kinase C (PKC) which in turn activated the c-Raf-1/MEK/ERK signaling cascade and triggered integrin α5 and δ-catenin expression. Together our data suggest that AKR1B10 promotes breast cancer metastasis through activation of PKC/ERK signaling pathway and upregulation of ii integrin α5 and …
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Die Bedeutung von BRCA1-assoziiertem Protein in der Entwicklung der lastinduzierten Myokardhypertrophie
… die Ras-abhängige Signaltransduktion von Raf zu Mek.In der vorliegenden Arbeit wurde die Funktion von BRAP in Kardiomyozyten in vitro und in vivo untersucht. Die Stimulation der Ras-Aktivität in Kardiomyozyten führte zu einer Verringerung der detektierten BRAP-Proteinmenge nach einer …
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Role of Raf family members in mouse development
Raf Proteine sind Serin/Threonin Kinasen, die als zentrale Elemente des Ras, Raf, Mek, Map Kinase Wegs, an der Weiterleitung von extrazellulären Signalen von der Zellmembran zu nukleären Effektoren beteiligt sind. Auf diese Weise kontrollieren sie elementare Prozesse wie Proliferation, …