Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"C-FLIP"”.
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
FLIP is an anti-apoptotic protein found overexpressed in a wide variety of cancers and is associated with drug resistance and poor prognosis. It acts by inhibiting the membrane-proximal steps of death receptor-mediated apoptosis at the death inducing signalling complex (DISC), but also has roles in …
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The role of c-FLIP in regulating resistance to ionizing radiation
… are required to improve therapeutic outcomes. FLIP, anendogenous caspase-8 inhibitor is a critical regulator of cell death that is frequently overexpressed in various cancers. FLIP overexpression in cancer contributes to resistance to death receptor- and chemotherapy- induced cell death. Thus, …
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Zelluläre Regulation von Leben und Tod durch Todeseffektordomänen (DED)-enthaltende Proteine: CAP3, c-FLIP R und p22-FLIP
… gehören u.a. Procaspase-8 und -10, während die c-FLIPs (engl.: cellular FLICE inhibitory proteins) zu den wichtigsten anti-apoptotischen DED-enthaltenen Proteinen gehören. Das CD95-vermittelte Todessignal wird nach Aktivierung des Rezeptors durch Anlagerung von cytosolischen Signalmolekülen mit …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… lipid rafts and that there was a decrease in c-FLIP (cellular FLICE-inhibitory protein) mRNA and protein. Downregulation of c-FLIP correlated with caspase activation and apoptosis induction. Transfection of cells with shRNA to c-FLIP also resulted in the localization of Fas to lipid rafts. These …
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CDDO-ME induces apoptosis in breast cancer cells via Ca2+ influx-mediated dilation of endoplasmic reticulum and c-FLIP downregulation
… vacuolation and subsequent apoptosis 51 5.c-FLIPL downregulation plays a critical role in CDDO-ME-induced apoptotic cell death, but not in vacuolation 58 6.Higher increase in intracellular Ca2+ and ROS levels as well as c-FLIP downregulation may contribute to a more potent anti-cancer effect …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
c-FLIP (cellular FADD-like-interleukin-ip-converting enzyme (FLICE) inhibitory protein) is a major anti-apoptotic protein that prevents apoptosis mediated by the death receptors TNF-R1, Fas, DR4 (TRAIL-R1) and DR5 (TRAIL-R2). c-FLIP binds to the death inducing signalling complex (DISC) via its …
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Immunevasion von Herpes-simplex-Virus Typ 1: Angriff auf Zellen des Immunsystems
… auf Proteinebene eine 50%ige Verringerung von c-FLIP(L) in HSV-1-infizierten unreifen Dendritischen Zellen. Die Transkriptmenge von c-FLIP(L) war nach HSV-1-Infektion jedoch erhöht, was dessen Herunterregulation durch eine verminderte Transkription oder mRNA-Stabilität ausschließt. Statt dessen …
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Mechanismen der Apoptoseresistenz der Tumorzellen des klassischen Hodgkin Lymphoms
… wurde neben FADD und Caspase-8/-10 auch c-FLIP nachgewiesen. c-FLIP ist ein Caspase-8/-10-Homolog, das ebenfalls an FADD bindet, aber aufgrund fehlender katalytischer Aktivität die Aktivierung der Caspasen im DISC und damit die Apoptoseinduktion verhindert. Eine starke c-FLIP-Expression …
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Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
… of anti-apoptotic proteins including Bcl-2 and c-FLIP. This produces an anti-apoptotic genotype by influencing both the intrinsic and extrinsic arms of the apoptotic pathway. Itraconazole is an antifungal agent that has been found to inhibit Smoothened (SMO), a crucial G protein-coupled receptor …
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Induction of Synthetic Lethality In Mutant Kras Cells For Non-Small Cell Lung Cancers Chemoprevention and Therapy
… enzyme (FLICE)-like inhibitory protein (c-FLIP) expression through activation of ERK/MAPK-mediated activation of c-MYC which means the mutant <em>KRAS</em> cells could be specifically targeted via TRAIL induced apoptosis. The expression level of Inhibitors of Apoptosis Proteins (IAPs) in …
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Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… hexokinases I/II, the caspase-8 inhibitor c-FLIP (FLICE inhibitory protein), and the IAP protein survivin. Most prominently, these studies showed a critical role for the anti-apoptotic Bcl-2 family protein Mcl-1, which is rapidly lost following translation inhibition with a half-life of …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… PUMA alongside repression of anti-apoptotic c-FLIP, previously shown by us to be a direct target of p53. We further provide evidence that Entinostat in the absence of p53, induces expression of CDK inhibitor p21 to result in cell cycle arrest through suppression of critical cell cycle genes …