Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"C—H functionalization"”.
-
Development of base metal-catalyzed C—H functionalization reactions
… catalysts thus far developed for these C—H functionalization processes have been comprised of precious or noble metals like palladium, rhodium, ruthenium, and iridium. This work describes the discovery and development of two novel base metal catalysts for C—H amination and alkylation that …
-
Asymmetric allylic C–H functionalization via palladium(II)/sulfoxide-oxazoline catalysis
Asymmetric C–H functionalization could deliver a highly efficient transformation by installing both oxidized functionality and absolute stereochemistry simultaneously. In this context, palladium(II)-catalyzed asymmetric allylic C–H functionalization of terminal olefins through the intermediacy of …
-
Generation of Alkyl Radicals Via C-H Functionalization and Halogen Atom Transfer Processes
… of alkyl radicals. The first is C-H bond functionalization via hydrogen-atom-transfer (HAT). HAT processes have been used as an effective approach for selectively activating C-H bonds via radical pathways. The other strategy to explore the generation of alkyl radicals is C-X bond …
-
Dual c–h functionalization of n-aryl amines & development of novel hydrogen bonding catalysts
… dual C–H activation, which in addition to α-functionalization of C(sp3)–H bonds of amines, simultaneously results in the functionalization of an ortho C(sp2)–H bond of the aryl ring. A classical Povarov approach to synthesize such polycyclic amines would require complex starting materials. A …
-
Palladium-mediated C–H Functionalization of Aliphatic Amines via High Valent Palladium(IV) Intermediates
… To this end, transition metal-catalyzed C–H functionalization represents a current area of research which aims to develop transformations that directly convert C–H bonds to C–C or C–heteroatom bonds, often enabling the synthesis of functionalized products that are not readily accessible using …
-
Synthetic diversity in C-H activation: development of selective and efficient C-H functionalization reactions
… serves as a ligand to Pd in order to promote functionalization from a monomeric Pd-π-allyl intermediate. From this, we hypothesized that stoichiometric amounts of BQ may serve to deactivate the Pd(II)/bis-sulfoxide, requiring the use of higher catalyst loadings. In an effort to improve on the …
-
Part I. Approaches Toward the Total Synthesis of Tyloindicine F; Part II. Palladium-Catalyzed C−H Functionalization of β-enaminones
… are a group of push-pull olefins whereas C-H functionalization/C-C coupling is a highly efficient method of constructing new carbon-carbon bonds. β-enaminones are highly polarized and their β; position is suitable for C-H functionalization by means of electropalladation. A novel methodology …
-
Zincative Functionalization of C–H Bonds Using Lithium Amide Zincate Bases
<p>Carbon–hydrogen bond functionalization is a highly desirable transformation as C–H bonds are plentiful in feedstock chemicals and the direct introduction of valuable functional groups improves atom economy and efficiency. However, field of direct C–H functionalization still has many challenges …
-
Harnessing the Reactivity of Sulfamate Esters and Sulfamides in Photoredox-Mediated Bond-Forming Reactions
… overcome significant hurdles when applied to C–H functionalization reactions. C–H functionalization processes take inspiration from the precision of enzymatic reactions in Nature, which are able to transform otherwise indistinguishable and unreactive C(sp3)–H bonds into high value functional …
-
Quinone-Catalyzed Amine α-C–H and α-C–C Functionalization
… introduction of amino groups. Emerging amine α-functionalization methodology enables the modification of existing amine-containing molecules at the α-amino position therefore providing new approaches to amine synthesis. Driven by our research interest in amine synthesis, we set out to explore …
-
Allylic C—H activation to access anti-1,3-amino alcohol motifs
… palladium (II)/sulfoxide-oxazoline catalyzed C—H functionalization between a terminal olefin and an N-tosyl carbamate, generating anti-1,3-oxazinanones. These motifs can be further elaborated upon, making this method ideal for the late stage diversification of complex molecules and …
-
I. Biomimetic oxidations using non-heme iron catalysis. II. Palladium- and hypervalent iodine-catalyzed tandem wacker-dehydrogenation of terminal olefins
… OF TERMINAL OLEFINS Catalytic C—H functionalization reactions promise to increase synthetic efficiency by enabling the direct installation of useful functionality onto traditionally unreactive hydrocarbon frameworks. The White group has pioneered a toolbox of synthetically useful …
-
Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
… tethered on acyclic precursors as well as α-C–H functionalization of intact piperazine rings. Although effective for the most part, these methods suffer from drawbacks such as the use of expensive catalysts, potentially toxic reagents, limited scope and functional group compatibility. Seeking to …
-
Design of Reagents and Ligands for Direct Palladium-Catalyzed C(sp³)–H Functionalization of Aliphatic Carboxylic Acids
Carboxylic acid directed C–H functionalization reactions have garnered substantial attention over the past few decades. While C–C bond-forming reactions have been extensively explored, C–heteroatom bond-forming reactions remain comparatively underdeveloped. This thesis consists of five chapters, …
-
Computational study on the selectivity of iron-containing hydroxylase
… alcohols from un-active C-H sites. Here C-H functionalization catalyzed by Iron-containing heme and nonheme were studied, using cytochrome P450 and PtlH as examples. In this work, the C-H activation in the hydroxylation reaction of a model substrate artemisinin catalyzed by three selective …
-
Advances in Selectivity of the Suzuki-Miyaura and Hofmann-Löffler-Freytag Reactions
… long-standing challenge. Cross-coupling and C–H functionalization processes have gathered significant attention over the past few decades as a result of their ability to rapidly generate molecular complexity. Despite these advances, a chemist’s ability to judiciously, selectively, and predictably …
-
The development and application of metal-catalyzed processes for organic synthesis
… a-Haloacetanilides via Palladium-Catalyzed C-H Functionalization We have discovered a palladium-catalyzed reaction that efficiently produces oxindoles from a-haloacetanilides through a net functionalization of an arene C-H bond. The high levels of regioselectivity observed in this cyclization …
-
Polarity Inversion in Silicon and Phosphorus Compounds
… acids that catalyze carbonyl activation, C–H functionalization, and glucose deoxygenation. Finally, a combined experimental and theoretical study on a class of geometrically constrained phosphine imides (i.e., phosphazenes) will be discussed. By imposition of non-VSEPR geometries through …
-
The Interplay Between Anions And Radicals In Synthesis, Spectroscopy, And Catalysis
… of the TiCl62- dianion towards photolytic C–H functionalization of hydrocarbons is also described. The photo-reactivity of TiCl62- allows for the activation of hydrocarbons, including methane. Mechanistic investigations, including the isolation and characterization of relevant TiIII species, …
Page 1 of 2