Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"C/EBPalpha"”.
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C/EBPalpha downregualtes c-jun expression
The transcription factor C/EBPa is crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells. In C/EBPa knockout mice, no mature granulocytes are …
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The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1
… von Bedeutung. Der Transkriptions faktor C/EBPalpha, ein an den CCAAT-Enhancer bindendes Protein, ist hingegen wesentlich verantwortlich für die Entwicklung von Granulozyten. Wir stellen hier den ersten Nachweis dafür vor, dass C/EBPalpha die Funktion von PU.1 blockiert. PU.1 und C/EBPalpha …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
The transcription factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils. We have recently shown that C/EBPa function is also impaired in acute …
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
… in transcriptional factors like C/EBPbeta, C/EBPalpha, PPARgamma and Glut4. Wild-type (WT) mouse embryonic fibroblast (MEFs) had increased mitotic clonal expansion (MCE) due to lack of estrogen but this was not seen in p27KO MEFs, that showed that the effects due to these two pathways were not …
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… positive transcriptional feedback loop between C/EBPalpha and PPARgamma. The PPARgamma activity toward its target genes was specifically inhibited by rapamycin upon insulin stimulation. I demonstrate that PPARgamma activity is dependent on amino acid sufficiency, revealing a molecular link between …
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant disorder of the blood system. Hematopoietic stem cells (HSCs) supply and maintain this system by differentiating via intermediates into lineage-restricted progenitors that strongly proliferate to keep up with the high turn-over of mature blood cells. In …