Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"C/EBPα"”.
-
Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell Moosa Rashid Qureshi C/EBPα is an ideal candidate to explore pre-leukaemic dysregulation of transcriptional networks because it is a significant player in normal myelopoiesis, it interacts with other …
-
Deciphering the Pathogenesis of Acute Myeloid Leukemia
… cells. Mutations of the transcription factor C/EBPα have been observed in 10 percent in AML with normal cytogenetics. In addition, internal tandem duplications (ITD) of FLT3 are frequently observed alterations in AML and coincide with mutations of C/EBPα. The effects of FLT3-ITD cooperation with …
-
Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… factors binding sites, O/E&NF1 and C/EBPα, may mediate Scriptaid-induced Glut4 up-regulation. Taken together, these data demonstrate that in osteocytes Scriptaid suppresses Sost expression through regulating HDAC5-MEF2C signaling. However, Scriptaid increases Glut4 expression through …
-
Mechanisms of pathological adipogenesis
… markers, PPARγ (5.46 ± 0.22; p = 0.024) and C/EBPα (25.3 ± 0.21; p = 0.0048), was higher in 7F2 cells cultured with adipogenic medium compared with basal medium, indicating that 7F2 cells differentiated into adipocytes. 7F2 cells also expressed previously unreported variant isoforms of ghrelin …
-
The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue
… cells resulted in a decrease in PPARγ and C/EBPα and a failure to differentiate into mature adipocytes. <br/><br/>These data demonstrate that the pathogenic overexpression of ILK in adipose tissue may contribute to insulin resistance in mice challenged on HF diet. Additionally, in this study …
-
Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
The dermonecrotic toxin family consists of the dermonecrotic toxin from Bordetella spp. (DNT), the cytotoxic necrotizing factors from Escherichia coli (CNF1, CNF2 and CNF3) and Yersinia pseudotuberculosis (CNFY), and the mitogenic toxin from Pasteurella multocida (PMT). These relatively large …