Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"C/EBP"”.
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… of CCAAT/enhancer binding protein alpha (C/EBP alpha) in early stages of myeloid differentiation and regulation we investigated the methylation status of the C/EBP alpha promotor region near the transcription start site in acute myelogenous leukemia (AML). Aberrant methylation of the C/EBP …
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Regulation des Blimp1-Promotors durch die Transkriptionsfaktoren C/EBP-Beta und NFATc1 in T-Lymphozyten
… über die Aktivität des Transkriptionsfaktors C/EBPβ (CCAAT/enhancer-binding protein) allein induziert. Die Transaktivierung des TATA-boxlosen Blimp1-Promotors (ca. 1 kb) durch C/EBPβ wird stärker über dessen proximale Hälfte vermittelt, an der jedoch keine direkte Bindung des …
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Effet du butyrate sur la réponse inflammatoire des cellules épithéliales intestinales et analyse fonctionnelle du facteur de transcription C/EBP[delta]
… inflammatoire des cellules intestinales. C/EBP[delta] est un facteur de transcription impliqué dans plusieurs processus cellulaires dont la réponse inflammatoire intestinale. Il est induit dans plusieurs tissus lors de la phase aiguë de l'inflammation, dont l'intestin, et est capable de …
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Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation
<p>CCAAT/enhancer-binding protein (C/EBP) &beta and C/EBP&delta are known to participate in the regulation of many genes associated with inflammation. However, little is known about the activation and function of C/EBP&beta and -&delta in inflammatory responses elicited by Fc&gamma receptor …
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CCAAT/Enhancer Binding Protein Alpha in UVB Responses in Human and Mouse Skin and Mouse Skin Tumorigenesis
… factor, CCAAT/enhancer binding protein alpha (C/EBP alpha), is induced by DNA damage and has a role in the G1 checkpoint. Here we demonstrate C/EBP alpha is induced in the epidermis of the human subjects exposed to UVB. To begin to determine the in vivo physiological significance of the …
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Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression.
… acted synergistically with IL-6-activated C/EBPβ in inducing CRP transactivation through the proximal CRP promoter. 2. A NF-κB site was localized in the proximal CRP promoter centered at position -69 overlapping the known OCT-1/HNF-1/HNF-3 sites. 3. The synergy between IL-6 and IL-1β in …
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Caractérisation des facteurs de transcription impliqués dans l'expression génique de cytokines chez les neutrophiles humains
… facteurs de transcription de la famille C/EBP, de même que l'activation de C/EBP[bêta] via sa phosphorylation en Thr 235 chez les neutrophiles humains. Grâce à la surexpression d'un répresseur des C/EBP (A-C/EBP2N3T) chez les cellules PLB-985 granulocytiques, nous avons montré l'importance …
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Transcriptional regulation of basal and phenobarbital-mediated expression of rat cytochrome 2B genes
… a functional CCAAT/enhancer binding proteins (C/EBP) site by cotransfection of C/EBP expression vectors and supershift assays with C/EBP antisera.
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Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
… factors and transcription factors C/EBP-α, C/EBP-β and PU.1 was measured by real-time PCR. Plasma PR3, pro-PR3, and proportion of mPR3+neutrophils were elevated in AASV. mPR3 and CD177 were co-expressed on a subset of neutrophils both in AASV and controls. mPR3 expression was not …
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… and activate CCAAT/enhancer binding protein (C/EBP), because inhibiting p38 MAPK blocked both leptin expression and prevented the increase in C/EBP nuclear translocation that was stimulated by TNFalpha treatment. Finally, it was found that pretreatment with peroxisome proliferator-activated …
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Untersuchungen über Regulationsmechanismen der 11beta-Hydroxysteroid Dehydrogenase Typ 1
… sowie von CCAAT/Enhancer-Binding-Proteinen (C/EBP) an ausgewählte Promotorregionen analysiert. Nach der Charakterisierung des Promotors wurden spezifische endogene und exogene Regulatoren untersucht. Fettsäuren modifizieren die Entstehung von Adipositas und Insulinresistenz. Ihre Wirkung wird …
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Regulação da adipogênese e da secreção de quemerina por ácidos graxos de cadeia média e pelo ácido graxo eicosapentaenóico em células 3T3-L1
… proteínas ligantes ao amplificador CCAAT (C/EBP) β, δ e α; PPARγ e quemerina. A incorporação de lipídios foi avaliada por Oil Red-O. Ainda, para o estudo sobre quemerina, adipócitos maduros foram incubados por 24 horas com os ácidos graxos descritos anteriormente, bem como com TNFα e …
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Regulation of the potential tumorsuppressor gene mad1 by G-CSF
… of the human mad1 promoter. Third, both C/EBP and Sp proteins regulate the activity of the mad1 promoter in response to G-CSF through CCAAT- and GC-boxes respectively. While Sp proteins bind to the mad1 promoter constitutively, C/EBP proteins, especially C/EBPbeta, appear to play major …
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TrkB and gene expression
… single or multiple elements, revealed that the c/ebp binding site together with the E-box are fundamental for the activation of c-fos downstream BDNF/TrkB. This result suggested that C/EBPs and bHLH transcription factors might collaborate to induce the activation of the promoter downstream of …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… SMAD3, and CCAAT/enhancer-binding protein-δ (C/EBP-δ) are part of a non-canonical TGF-β signaling pathway that is responsible for iron-induced C3 expression. Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced C3 expression levels. Knockdown of SMAD3 blocked …
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Regulation of flt3 gene expression in haematopoietic and leukaemic stem cells
… the link between the \(in vivo\) binding of C/EBP and c-Myb on regulatory elements and epigenetic remodelling in the differential regulation of \(flt3\) in leukaemic cells. Finally, I identify the histone modifiers TIP60 and CBP as potential mediators of the epigenetic regulation of \(flt3\) in …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
The transcription factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils. We have recently shown that C/EBPa function is also impaired in acute …
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A maternal low-protein diet during gestation induces hepatic autophagy gene expression only in the female offspring Sprague-Dawley rats
… the maternal low-protein diet induces ATF4 and C/EBP homology protein (CHOP) binding at the regions of specific autophagy-related genes in the liver of female offspring through differential cooperative regulation. Overall, our data demonstrated that hepatic autophagy gene expression could be …
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