Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Bystander activation"”.
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
… IL-12 and IL-18 can induce antigen-independent bystander activation of memory T cells. The ZFP36-family of RNA binding proteins, including ZFP36 and ZFP36L1, contribute to the regulation of mRNA stability, protein translation and therein, T cell function. Appropriate regulation of T …
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Vaccination and immunological memory
… tuberculin (PPD), and Candida albicans (C.alb). Bystander expansion occurred in Thmem but not in Thnaive cells. Antibody production against TT peaked ~2 weeks post-vaccination and gradually declined. However, pre-existing antibody against the other antigens did not change. It appears that, …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… transcription possibly contributing to a role of bystander activation, i.e. being influenced by external factors, rather than actively contributing to disease processes. The exact role of HERVs in RA pathology remains elusive; however this research proposes several mechanisms by which HERV-K …
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Not-so-innocent bystanders? Investigating non-antigen specific CD8+ T cell activation in autoimmune prognosis
… and Kent) shows that genes associated with bystander activation (BA), the non-TCR-specific activation of T cells were enriched in patients with relapsing disease. Therefore, non-antigen-specific (“bystander”) cells may be playing an important role in prognosis. I sought to address the …
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NK cell determinants of immunity to mycobacterium tuberculosis in humans
… during TB disease was dependent on T cell bystander activation. Despite important findings in peripheral blood, the TB field lacks a comprehensive understanding of phenotypic and functional characteristics of NK cells in human tissues, where the disease mostly manifests. To address this …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
… with HuAd5-specific T cells suggesting bystander T cell enhancement of the vaccine response. I used the mouse model to determine if pre-existing HuAd5-specific T cells contributed by bystander activation to the enhanced spike-specific T cell responses seen when IDPs were immunised with …
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
… of Mtb antigen by the TCR, rather than through bystander activation. IL-22 is produced by CD4+ T cells that appear to be conventional, rather than MAIT, γδ or iNKT cells. Indeed, analysis of the TCR clonality using vβ repertoire typing revealed similar repertoire usage between IL-22, …
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Der Einfluß von Virusinfektion und Impfung auf autoreaktive T-Lymphozyten bei der Multiplen Sklerose
In der sogenannten ViMS-Studie, bei der MS-Patienten und gesunde Kontrollpersonen mit einer Influenza-Spaltvakzine geimpft und für einen zum Teil viermonatigen Zeitraum im Verlauf nachbeobachtet wurden, ergab sich weder mit dem sensitiven IFNg-ELISPOT noch mit der quantitativen RT-PCR ein Anhalt …