Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Burkitt lymphoma"”.
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Sporadic Burkitt Lymphoma in Adults; Clinico-pathologic Characteristics and Immunohistochemical Study
… and treatment outcome of patients with sporadic Burkitt lymphoma (BL) in adults. METHODS: A survey of 1,422 NHL patients who had been diagnosed at Korea Institute of Radiological & Medical Sciences between 1993 and 2003 identified 26 patients with BL (1.8%). All these cases were reviewed by …
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Anti-cancer effects of aqueous extracts of Dodonaea Viscosa on Burkitt lymphoma
… of aqueous extracts of Dodonaea Viscosa on Burkitt lymphoma Cancer is a leading public health problem worldwide, and although modern treatments have undeniably improved patient outcomes, many cancers remain refractory or untreatable. New and more effective treatments are needed, and natural …
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Development of a Burkitt Lymphoma cell line with inducible expression of activated B-cell factor-1
… by ABF- 1, I have attempted to construct a Burkitt Lymphoma cell line allowing tetracycline regulated expression of ABF-1. The tetracycline repressor gene was first added to these cells, creating a parental line oftet repression. Next, both a full-length and a truncated version of ABF -1 …
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Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes
Burkitt Lymphoma (BL) is a B cell non-Hodgkin lymphoma that occurs as three distinct subtypes, namely: endemic, sporadic, and immunodeficiency/HIV-associated. This cancer represents a frequent cause of mortality among HIV+ people in Southern Africa which has the highest incidence of HIV/AIDS …
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Clinical-pathological characterisation of children with B-cell non-Hodgkin lymphoma over a ten year period at a tertiary centre in Cape Town
Background: We characterized B-cell non-Hodgkin lymphoma (NHL) cases over ten years at a tertiary children's hospital to contribute to the body of knowledge on pediatric lymphoma in developing countries with a high human immunodeficiency virus (HIV) burden. Methods: A retrospective cohort study …
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Burkitt and Burkitt-like lymphoma/leukaemia at Groote Schuur Hospital from 2005 to 2014: a retrospective review
… is at increased risk of developing non-Hodgkin lymphoma, particularly high grade aggressive subtypes such as Burkitt- and Burkittlike lymphoma (also known as B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma). Methods: Ten year …
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Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
… in Triple negative breast cancer cells.</p> <p>Burkitt lymphoma is an aggressive subtype of Non-Hodgkin’s lymphoma driven by the overexpression of c-MYC. In this dissertation we show inhibition of GCN5 reduces MYC-driven gene expression in Burkitt lymphoma and therefore reduces cancer phenotypes …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
… recent next generation sequencing of human Burkitt lymphoma samples revealed that a significant proportion of them have mutations of Id3. This finding suggests that Id3 may be a tumor suppressor gene in the lymphoid system. Utilizing various Id3 knockout and conditional knockout mouse …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
Paediatric mature B-cell non-Hodgkin lymphoma (B-NHL) is a highly aggressive disease with one of the fastest growth rates of any human malignancy. The subtypes are Burkitt and Burkitt-like lymphoma/leukaemia, diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma; with Burkitt …
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Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
… types. DDX3X is frequently mutated or deleted in Burkitt lymphoma and in other forms of aggressive, MYC-driven lymphoma, which arise from germinal centre (GC) B cells. DDX3X mutations are especially enriched in male patients. In contrast, DDX3Y is never mutated in lymphoma. Previous work in our …
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Expression and role of the human anti-apoptotic bfl-1 gene in Hodgkin's Lymphoma
Hodgkin's Lymphoma (HL) is identified histologically by the presence of mononuclear Hodgkin (H) cells and multinucleated Reed-Stemberg (RS) cells surrounded by a background of lymphocytes, plasma cells, eosinophils, histocytes and stromal cells in the affected lymph nodes. HL affects on average 2.5 …
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Revealing the role of Gα13 in germinal centre lymphomas
Diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL) are aggressive B cell malignancies, arising from the transformation of germinal centre (GC) B cells. Although potentially curable with immuno-chemotherapy, 40% of DLBCL patient relapse and eventually succumb to their disease. In recent …
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The biological effects of HIV-1 Nef on the development of B-cell Lymphoma
… HIV burdens compared to the rest of the world. Burkitt lymphoma (BL) is an extremely aggressive cancer that is considered to be a highly prevalent subtype of Non-Hodgkin Lymphoma (NHL) affiliated with chronic HIV infection. While the immunosuppressive aspect of HIV remains a primary cause for …
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Identifying Children with Constitutional Mismatch Repair Deficiency (CMMR-D) Syndrome in the Expanding Lynch Syndrome population in Cape Town
… cancers, high-grade gliomas, non-Hodgkin T-cell lymphomas and leukaemias. It is characterized by biallelic germline mutation of one of four possible MMR genes resulting in loss of protein expression that can be identified by applying immunohistochemistry to formalin fixed paraffin embedded tissue …
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An investigation of the impact of the B cell lymphoma factor Activation Induced Cytidine Deaminase (AICDA/AID) on epigenetic plasticity
… particularly B-cell derived non-Hodgkin lymphomas, but has also been associated with other inflammation-associated cancers, including colorectal cancer (CRC). The widely recognised normal role of AICDA is in antibody-producing B cells, where its cytosine deaminating ability within DNA is …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
The commonest childhood Non-Hodgkin Lymphomas (NHLs) form three major categories: the aggressive mature B-cell NHLs including Burkitt lymphoma (BL), Anaplastic Large Cell Lymphomas (ALCL), and lymphoblastic lymphomas. Most childhood NHL is high-grade and generally responds well to high-intensity …
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Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
… Epstein-Barr-Viren (EBV) und der Entwicklung von Burkitt-Lymphomen, Hodgkin-Lymphomen sowie Nasopharynx-Karzinomen herstellen. Für die Transformation einer mit EBV infizierten humanen B-Zelle ist die Expression des Latenten Membranproteins 1 (LMP1) des Epstein-Barr-Virus essentiell. LMP1 ist ein …