Global ETD Search
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Showing 1 to 4 of 4 for “"Burkholderia thailandensis"”.
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Infections of Drosophila melanogaster with pathogens: Mycobacterium marinum and Burkholderia thailandensis
… thesis focuses on infections of Drosophila with Burkholderia thailandensis. B. thailandensis is a Gram-negative bacterium closely related to Burkholderia pseudomallei, the causative agent of melioidosis. The study revealed that B. thailandensis was pathogenic in the fly; it activated the fly …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
… infection with Salmonella Typhimurium or Burkholderia thailandensis. Furthermore, mice deficient in IRF8 were impaired in their ability to produce IL-18 and suffered higher bacterial burdens. Altogether, our data highlights the role of IRF8 as a transcriptional regulator of NAIPs for NLRC4 …
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… to a second cytosolic Gram-negative bacterium, Burkholderia thailandensis, but not to the cytosolic Gram-positive bacterium Listeria monocytogenes. Using mutational analysis, I determine that GBP1 targeting is directed by a C-terminal Polybasic Motif (PBM) centered around three arginine …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
<p>Burkholderia pseudomallei is an opportunistic soil pathogen that causes melioidosis, a life-threatening human disease prevalent in Southeast Asia, northern Australia, the Middle East, Africa, and South America. The organism also causes disease in plants and animals. Persons with severe …