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Showing 1 to 20 of 27 for “"Burkholderia pseudomallei"”.
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Surveillance for Burkholderia pseudomallei in aquaria
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
The potential bio-terror threat posed by Burkholderia pseudomallei highlights the need for an effective vaccine. Immunisation and challenge experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
Zaire ebolavirus (EBOV) and Burkholderia pseudomallei are the causative agents of Ebola virus disease (EVD) and melioidosis, respectively. Early diagnosis is critical for halting the spread of the disease or providing treatment of the disease. Current diagnosis for EBOV includes polymerase chain …
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Predicting Toxin-Antitoxin Systems Responsible for Host-Induced Persistence of Burkholderia pseudomallei
Burkholderia pseudomallei (BPM) is the infectious agent that causes the disease. Melioidosis. The mortality rate for Melioidosis is up to 40% regardless of treatment. Despite the ability of certain antibiotics to reduce mortality, infection relapse occurs in 15-23% of treated patients. The …
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Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
Within the Burkholderia genus of Gram-negative bacteria exist two clades known to cause human disease: the B. pseudomallei complex and B. cepacia complex. Species of concern within the B. pseudomallei complex include B. mallei and the eponymous B. pseudomallei. Both are designated as Tier 1 Select …
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
<p>Burkholderia pseudomallei (Bp) is a saprophytic, gram-negative aerobe and the causative agent of the disease melioidosis. Melioidosis is an infectious disease that occurs in humans and animals and is prevalent in Southeast Asia, northern Australia and other tropical areas. Transmission occurs …
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
Burkholderia pseudomallei is a Gram-negative environmental saprophyte and causative agent of melioidosis. As a facultative intracellular pathogen, B. pseudomallei uses secretion systems as primary virulence factors. The type 3 secretion system (T3SS) is used to escape the phagosome while the type 6 …
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Structural studies of Burkholderia pseudomallei invasion protein D (BipD), 2,4'-dihydroxyacetophenone dioxygenase (DAD) and L-threonine dehydrogenase (TDH)
… can be applied to real life challenges.<br/><br/>Burkholderia pseudomallei invasion protein D (BipD) not only has the potential for misuse as a bioterrorist weapon, due to its air-borne infectivity, but also causes the disease melioidosis, which can kill within 48 hours. The structure of this …
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THE BIPC MINOR TRANSLOCASE MEMBRANE PROTEIN OF THE BURKHOLDERIA TRANSLOCON
… proteins (virulence factors) into a host cell. Burkholderia pseudomallei is a bacterium of high concern to the health of the human population. B. pseudomallei is a human pathogen which is tasteless, odorless, and colorless. It is transmittable subcutaneously, through contaminated food and water, …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
<p>Burkholderia pseudomallei is an opportunistic soil pathogen that causes melioidosis, a life-threatening human disease prevalent in Southeast Asia, northern Australia, the Middle East, Africa, and South America. The organism also causes disease in plants and animals. Persons with severe …
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Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
In this study, a Burkholderia mallei ∆tonB mutant deficient in iron acquisition was constructed, characterized and evaluated for its protective properties in acute inhalational mouse models of glanders and melioidosis infection. Compared to wild type, the B. mallei ΔtonB exhibits slower growth …
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Investigation of dendritic cells as a vector for vaccine delivery
… responses to the Gram negative bacillus <i>Burkholderia pseudomallei</i>. This bacterium is the causative agent of melioidosis, a disease endemicto areas of south-east Asia and northern Australia, to which presently no licensed vaccine exists.<br></br><br></br>Purified DC were pulsed with …
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Antibody detection of Burkholderia pseudommallei and Burkholderia mallei
… use in immunological assays for the detection of Burkholderia pseudomallei and Burkholderia mallei. Monoclonal antibodies recognising a high molecular weight polysaccharide material found in some strains of both species have been shown to be effective in recognising B. pseudomallei and B. mallei …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for …
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The effect of glibenclamide on the pathogenesis of melioidosis
… Melioidosis is caused by the soil saprophyte, Burkholderia pseudomallei, a motile Gram-negative bacillus, and is associated with a mortality rate that approaches 50% in Northeast Thailand. The most important risk factor for melioidosis is diabetes mellitus, and two-thirds of all adult patients …
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Development of Au-Pt Nanoflowers as Nanoenzyme for Highly Sensitive Immunoassay: Application to the Detection of Melioidosis Biomarker
… (CPS) expressed on the cell envelopes of Burkholderia pseudomallei causing Melioidosis, an infectious disease of global health concern. Utilizing the inherent peroxidase-like activity of Au-Pt NFs, we developed Nano-Enzyme Linked Immunosorbent Assay (N-ELISA) and Lateral Flow Immunoassay …
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Infections of Drosophila melanogaster with pathogens: Mycobacterium marinum and Burkholderia thailandensis
… thesis focuses on infections of Drosophila with Burkholderia thailandensis. B. thailandensis is a Gram-negative bacterium closely related to Burkholderia pseudomallei, the causative agent of melioidosis. The study revealed that B. thailandensis was pathogenic in the fly; it activated the fly …
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A Time-Gated Fluorescence Instrument and Its Applications Using Mn-Doped I(II)-III-VI Nanocrystal Probes
… magnetic bead-based sandwich immunoassay for the Burkholderia pseudomallei capsular polysaccharide antigen using Pf4c4 monoclonal antibody. The assay was found to be very sensitive (2σ LOD at 42.54 pg/mL, N = 9). Notably, this assay did not involve the use of enzyme-based methods, which tend to …
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Structure of T6SS components and assessment of potential Gram-ve drug targets
… 5. PBP3 from both Pseudomonas aeruginosa and Burkholderia pseudomallei is the focus of chapter 6. This protein is essential in bacteria as it catalyses the cross-linking of peptidoglycan. Peptidoglycan provides bacteria with structural rigidity and strength to withstand pressures that would …
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