Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Burkholderia mallei"”.
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Antibody detection of Burkholderia pseudommallei and Burkholderia mallei
… use in immunological assays for the detection of Burkholderia pseudomallei and Burkholderia mallei. Monoclonal antibodies recognising a high molecular weight polysaccharide material found in some strains of both species have been shown to be effective in recognising B. pseudomallei and B. mallei …
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Virulence associated functions and vaccine potential of the burkholderia mallei type three secretion effector BopA
The detailed mechanism(s) of Burkholderia mallei pathogenesis is virtually unknown, with the production of a polysaccharide capsule and presence of secretion systems as the only known mechanisms associated with virulence. Various gram-negative pathogens utilize a secretion system known as type III, …
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Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
In this study, a Burkholderia mallei ∆tonB mutant deficient in iron acquisition was constructed, characterized and evaluated for its protective properties in acute inhalational mouse models of glanders and melioidosis infection. Compared to wild type, the B. mallei ΔtonB exhibits slower growth …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
Burkholderia mallei (Bm) and B. pseudomallei (Bpm) are facultative intracellular pathogens and the causative agents of glanders and melioidosis. At present, effective vaccines for the prevention of glanders, or melioidosis in humans, are not available. However, renewed attention has been directed …
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Construction, characterization, and evaluation of CLH001 as a vaccine candidate against respiratory glanders
Burkholderia mallei is the causative agent of glanders, an incapacitating disease with high mortality rates in respiratory cases. Its endemicity and ineffectual treatment options emphasize its public health threat and highlight the need for a vaccine. In this study, we constructed and characterized …
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Demonstration of novel enoyl-acyl carrier protein reductases in Vibrio cholerae
… by other groups in two important pathogens: Burkholderia mallei and Pseudomonas aeruginosa (Lu and Tonge 2010; Zhu, Lin et al. 2010). However, fabV was not the only ENR expressed in Vibrio cholerae. Screening of another cosmid library with higher genome coverage identified yet another gene …