Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Burkholderia cenocepacia"”.
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Experimental evolution of Burkholderia cenocepacia biofilm populations
… cooperative communities derived from a clone of Burkholderia cenocepacia during approximately 1500 generations of biofilm selection. This long-term evolution was enabled by a new experimental method that selects for daily cycles of colonization, biofilm assembly, and dispersal. Each of six …
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Structural studies to inform antimicrobial drug discovery and the basis of immunity against T6 effectors
… synthase, EC: 4.6.1.12) from two pathogens (Burkholderia cenocepacia and Plasmodium falciparum) has been investigated. IspF is an enzyme of isoprenoid-precursor biosynthesis and is considered to be a potential drug target. The results of structural and fragment-screening efforts presented …
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Formulation and efficacy of liposome-encapsulated azithromycin for pulmonary infection due to Pseudomonias Aeruginosa
… with highly resistant pathogens such as Burkholderia cenocepacia and Pseudomonas aeruginosa, is principally associated with cystic fibrosis. The effective management of pulmonary infection in cystic fibrosis patients is not controllable due to the multidrug-resistant strains and potential …
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Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
Burkholderia cenocepacia, an opportunistic Gram-negative bacterium that causes serious respiratory infections in patients with cystic fibrosis, produces the extracellular bacterial lipocalin protein BcnA upon exposure to<br/>sublethal concentrations of bactericidal antibiotics. BcnA captures a …
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The role of bacterial interspecies communication in polymicrobial infection of the cystic fibrosis lung
… CF are co-infected with Pseudomonas aeruginosa, Burkholderia cenocepacia and Stenotrophomonas maltophilia. These latter bacteria produce signal molecules of the diffusible signal factor (DSF) family, which are cis-2-unsaturated fatty acids. Previous studies showed that DSF from S. maltophilia …
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Character displacement in Burkholderia biofilm communities and the effect of adaptive history on the evolution of niche breadth
… in a synergistic, biofilm-adapted population of Burkholderia cenocepacia, an opportunistic pathogen of cystic fibrosis patients that infects by producing diverse biofilms. Additionally, we examined effects of adaptive history on the ability of biofilm generalists and specialists to adapt to …
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GLYCOMIMETIC LIGANDS TARGETING BACTERIAL LECTINS: RATIONAL DESIGN, SYNTHESIS AND BIOPHYSICAL EVALUATION
… from the opportunistic Gram-negative pathogen Burkholderia cenocepacia. B. cenocepacia is a globally spread, multidrug-resistant bacterium that causes severe respiratory infections, primarily in immunocompromised individuals or cystic fibrosis patients. Its lectin BC2L-C, proposed to play a key …