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Showing 1 to 20 of 87 for “"Burkholderia"”.
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Antibody detection of Burkholderia pseudommallei and Burkholderia mallei
… use in immunological assays for the detection of Burkholderia pseudomallei and Burkholderia mallei. Monoclonal antibodies recognising a high molecular weight polysaccharide material found in some strains of both species have been shown to be effective in recognising B. pseudomallei and B. mallei …
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Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
Within the Burkholderia genus of Gram-negative bacteria exist two clades known to cause human disease: the B. pseudomallei complex and B. cepacia complex. Species of concern within the B. pseudomallei complex include B. mallei and the eponymous B. pseudomallei. Both are designated as Tier 1 Select …
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Surveillance for Burkholderia pseudomallei in aquaria
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Experimental evolution of Burkholderia cenocepacia biofilm populations
… cooperative communities derived from a clone of Burkholderia cenocepacia during approximately 1500 generations of biofilm selection. This long-term evolution was enabled by a new experimental method that selects for daily cycles of colonization, biofilm assembly, and dispersal. Each of six …
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
The potential bio-terror threat posed by Burkholderia pseudomallei highlights the need for an effective vaccine. Immunisation and challenge experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for …
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THE BIPC MINOR TRANSLOCASE MEMBRANE PROTEIN OF THE BURKHOLDERIA TRANSLOCON
… proteins (virulence factors) into a host cell. Burkholderia pseudomallei is a bacterium of high concern to the health of the human population. B. pseudomallei is a human pathogen which is tasteless, odorless, and colorless. It is transmittable subcutaneously, through contaminated food and water, …
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Novel agents with inhibitory activity against the Burkholderia cepacia complex
… Pseudomonas aeruginosa, and members of the Burkholderia cepacia complex (Bcc). "B. cepacia" was first recognised in the late 1970's as a cause of life threatening respiratory infections in CF. Initial clinical observations noted that 20% of colonised CF patients developed "cepacia syndrome", …
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Studies of the nature of Burkholderia cepacia in cystic fibrosis
Burkholderia cepacia is an opportunistic pathogen that colonises of the lungs of cystic fibrosis (CF) patients, with a frequently fatal outcome. Antibiotic resistance is common and highly transmissible epidemic strains have been described in the UK. 37 B. cepacia isolates from clinical and …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
Zaire ebolavirus (EBOV) and Burkholderia pseudomallei are the causative agents of Ebola virus disease (EVD) and melioidosis, respectively. Early diagnosis is critical for halting the spread of the disease or providing treatment of the disease. Current diagnosis for EBOV includes polymerase chain …
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Infections of Drosophila melanogaster with pathogens: Mycobacterium marinum and Burkholderia thailandensis
… thesis focuses on infections of Drosophila with Burkholderia thailandensis. B. thailandensis is a Gram-negative bacterium closely related to Burkholderia pseudomallei, the causative agent of melioidosis. The study revealed that B. thailandensis was pathogenic in the fly; it activated the fly …
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Purification and characterization of a novel protease form Burkholderia strain 2.2N
The bacterium Burkholderia strain 2.2 N is a soil isolate and a member of a group of non-obligative predator bacteria that can prey on other microorganisms or grow saprophytically. The bacterium has anti-bacterial, anti-fungal, anti-yeast and anti-protozoan activities. Burkholderia strain 2.2 N …
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Predicting Toxin-Antitoxin Systems Responsible for Host-Induced Persistence of Burkholderia pseudomallei
Burkholderia pseudomallei (BPM) is the infectious agent that causes the disease. Melioidosis. The mortality rate for Melioidosis is up to 40% regardless of treatment. Despite the ability of certain antibiotics to reduce mortality, infection relapse occurs in 15-23% of treated patients. The …
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The Evolutionary Diversity and Biological Function of Phenazine Metabolite Biosynthesis in Burkholderia SPP
<p><em>Burkholderia </em>encompass a group of ubiquitous Gram-negative bacteria that include numerous saprophytes, as well as several species that cause infections in animals, immunocompromised patients, and plants. Some species of <em>Burkholderia </em>produce colored redox-active secondary …
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
<p>Burkholderia pseudomallei (Bp) is a saprophytic, gram-negative aerobe and the causative agent of the disease melioidosis. Melioidosis is an infectious disease that occurs in humans and animals and is prevalent in Southeast Asia, northern Australia and other tropical areas. Transmission occurs …
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Integrated functional anlaysis of quorum-sensing in the rice pathogenic bacterium Burkholderia glumae
… major virulence factors of the rice pathogen, Burkholderia glumae. The QS system of B. glumae is mediated by the core genes, tofI and tofR. N-octanoyl-L-homoserine lactone, the primary QS signal molecule of B. glumae, is synthesized by tofI and binds to the cognate receptor tofR at the quorum …
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
Burkholderia pseudomallei is a Gram-negative environmental saprophyte and causative agent of melioidosis. As a facultative intracellular pathogen, B. pseudomallei uses secretion systems as primary virulence factors. The type 3 secretion system (T3SS) is used to escape the phagosome while the type 6 …
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Burkholderia phytofirmans strain PsJN effects on drought resistance, physiological responses and growth of switchgrass
… we inoculated switchgrass seedlings with Burkholderia phytofirmans strain PsJN. Two experiments were conducted to determine the initial and long-term responses of switchgrass to PsJN inoculation by tracking growth and leaf physiology. In a third experiments, we tested the effects of PsJN …
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