Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Bunyaviridae"”.
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Reverse genetics system and fucntion of NSM protein of Rift Valley fever virus (family Bunyaviridae, genus phlebovirus)
… fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease that is endemic in sub-Saharan African countries and results in large epidemics among humans and livestock. Furthermore, it has potential as a bioterrorist agent …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
Punta Toro virus (PTV) is transmitted by sandlfies (Lutzomyia spp.) in Panama and Northern Columbia and causes an acute febrile illness in humans lasting 2-5 days. Human seroprevalence in regions within Panama have been reported up to 34% in the most easterly region of Darien however little is …
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The production of a Crimean-Congo haemorrhagic fever virus diagnostic antigen in plants
… (CCHFV), a nairovirus that forms part of the Bunyaviridae family. CCHFV has a case fatality rate of approximately 40%. Current diagnostic methods for CCHFV involve the use of live virus antigen, requiring biosafety level 4 (BSL4) conditions for safe handling. The development of a safer …
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Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana
… belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing high numbers of neonatal fatalities in animals and occasional fatalities in humans. It is endemic to parts of Africa and the Arabian Peninsula, but is …
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Countermeasures Against Viral Hemorrhagic Fevers
… families include: Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. All these viruses are enveloped and contain a single-stranded RNA genome. However, the viruses differ in their pathogenesis, transmissibility, natural host, and geographical distribution. VHFs usually begin …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
… both humans and livestock. RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and general transcription shutoff including IFN-β mRNA synthesis. Currently, no effective …
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La Crosse Virus in Southwestern Virginia: Role of Exotic Mosquito Species and Effect of Virus Infection on Feeding
The family Bunyaviridae is the largest of vertebrate diseases and includes the mosquito-borne disease La Crosse (LAC) virus. Vectors include the major vector Aedes triseriatus and two accessory vectors Aedes albopictus and Aedes japonicus. In the past several decades there has been an increase in …
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Molecular analysis of La Crosse virus transcription and replication in host cells
… (LAC) virus is an arthropod-borne virus (family Bunyaviridae, genus Orthobunyavirus) transmitted by Aedes triseriatus mosquitoes and is an important cause of pediatric arboviral encephalitis in the United States. Like other arthropod-borne viruses, LAC virus can be very cytolytic in mammalian …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
… (RVFV) is a phlebovirus of the virus family, Bunyaviridae. Since the early 1900s, RVFV has continually caused economically devastating outbreaks in livestock and severe disease in humans. In pregnant ewes, RVFV infection can cause abortions in up to 100% of animals and high mortality rates (up …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
… Phlebovirus (RVFV) ist ein Mitglied der Familie Bunyaviridae. Es wird durch Stechmücken übertragen und ist in der Lage zahlreiche Wirtspezies zu infizieren. Beim Menschen kann die Infektion zu Hepatitis, hämorrhagischem Fieber und Enzephalitis mit tödlichem Ausgang führen. Bei Rindern verläuft …
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BEHAVIORAL ECOLOGY OF ORYZOMYS PALUSTRIS (MARSH RICE RAT) IN COASTAL TEXAS: IMPLICATIONS FOR THE LIFE-HISTORY STRATEGY OF BAYOU VIRUS (BAYV)
Prior to the 1990s, Hantaviruses (Family: Bunyaviridae) and their manifest human syndromes were viewed as public health concerns primarily for Eurasia. However, the Sin Nombre virus (SNV) outbreak of 1993-94 in the southwestern U. S. brought Hanta to North America’s front door, fueling intense …
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Characterizing global gene expression and antiviral response in Frankliniella occidentalis infected with Tomato spotted wilt virus
Frankliniella occidentalis, the western flower thrips, transmits the plant-pathogenic virus, Tomato spotted wilt virus (TSWV), through a circulative-propagative transmission strategy. The virus infects and replicates in the insect, traversing membrane barriers as it moves from the midgut to the …