Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Bumetanide"”.
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… due to intracellular accumulation of chloride. Bumetanide is a potential adjunct treatment for neonatal seizures, which reduces intracellular chloride concentrations by inhibiting the sodium-potassium-chloride cotransporter NKCC1. This accelerates the excitatory to inhibitory switch in GABA …
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Regulation of COX-2 and PGE2-Dependent Recovery of Intestinal Barrier Function
… of the Na/K/2Cl cotransporter inhibitor bumetanide, abolished the PGE2-induced rise in Isc and subsequent elevations in TER. PGE2 induced a shift in claudin-1 from the Triton-X soluble to insoluble fraction, beginning 4-hour after PGE2 administration, which was prevented by bumetanide. …
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Der Transport anionischer Substanzen durch die basolaterale Membran proximaler S2-Segmente der Kaninchenniere : inverse Beziehung zwischen der Affinität zum p-Aminohippurat-Transportsystem und der Transportrate
… transport rates of several drugs (Probenecid, bumetanide, mefruside) which are substrates of the PAH transporter and which differ markedly regarding their hydrophobic properties (log P values ranging from 1-3) were determined on non-perfused proximal S2 segments microdissected from rabbit …
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Characterization of a human renal organic anion transporter
… partner a-ketoglutarate, and the loop diuretics bumetanide and furosemide. Uptake also showed chloride dependence, characteristic of the basolateral organic anion/dicarboxylate exchange in renal systems. Mutation of two amino acids, Lys382 and Arg466, positions positively charged in all OATs and …
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Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models
… inhibitor furosemide, and the related compound bumetanide, for their effect on the malaria parasite-induced choline influx resulted in the identification of 13 effective compounds. Of these, 5 showed inhibitory activity in vitro against the parasite at a concentration of 10 μM. Analysis of the …
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Influence of magnesium on salivary gland secretion: physiological and pathophysiological studies
… (NMDG)), dinitrophenol (DNP) bumetanide, amiloride, quinidine or lidocaine resulted in significant (P<0.01) increases in [Mg2+]i. In the presence of these inhibitors ACh still stimulated a reduction in {Mg2+]i. Taken together, these studies on animal model have demonstrated …
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Developing Novel Conservative Treatments For 2 Endometrial Cancer By Targeting Aquaporin-1
… 100 μM, KeenMind 33 μM), ion channel inhibitors (Bumetanide derivatives AqB011 60 μM-100 μM, 5-HMF, 1mM, 5-PMFC 0.5 mM), and non-specific AQP4 modulators (IMD-0354 0.2 μM, TGN-020 3 μM). A wide range of dose of all drugs were tested and optimal doses causing 50% inhibition of invasion were …