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Showing 1 to 10 of 10 for “"Buchwald-Hartwig-amination"”.
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INTRAMOLECULAR CARBON-NITROGEN COUPLING FROM ISOLATED MONOHYDROCARBYL PALLADIUM(IV) COMPLEXES PREPARED USING H2O2 AS TERMINAL OXIDANT
… amines through a Pd(0)/Pd(II) catalytic cycle (Buchwald-Hartwig amination). A newer, more atom-economical approach to the synthesis of amines is based on oxidative C-H amination. Recent studies of C-H amination propose the involvement of Pd(II)/Pd(IV) catalytic cycle through a C-H activation …
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Synthesis and Application of Air-Stable Secondary Phosphine Oxide, Oxime, and Amine-Phosphine Palladium(II) Complexes in Transfer Hydrogenation and Cross-Coupling Reactions
… the precatalysts were effective for the Buchwald-Hartwig amination of aryl bromides and aryl chlorides. We discovered that the identity of the amine ligand significantly impacts catalyst efficiency with linear primary alkyl amines providing the most active catalysts. A comparison study …
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Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
… efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered primary and secondary amines and b) coupling of 2-aminopyridine derivatives with aryl and heteroaryl halides. Although …
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Design and synthesis of polymeric semiconductors for perovskite applications
… approach; We found that utilizing the Buchwald-Hartwig amination protocol using primary aryl amines and aryl dihalides afforded highly reproducible, high yielding family of polymers, which could be purified by a simple sequence of precipitations. Appropriate selection of pendant …
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Synthesis, Activation and Catalytic Activity of N-Heterocyclic Carbene Bearing Palladium Catalysts
… in cross-coupling (Suzuki- Miyaura, Buchwald-Hartwig) and related (catalytic dehalogenation, £-ketone arylation) reactions is also discussed. A comparison of the activity of a variety of (NHC)Pd complexes as pre-catalysts for cross-coupling reactions was carried out. The results …
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Development of Cobalt and Nickel N-Heterocyclic Carbene Complexes for Cross-Coupling Reactions
… reactivity in Negishi, Suzuki-Miyaura, and Buchwald-Hartwig amination cross-coupling reactions. Co(IPent)Cl2(Pyr), Co(IPentCl)Cl2(Pyr), and Co2IPr2(OAc)4 were prepared, identified by X-ray crystallography, and evaluated in preliminary Negishi cross-coupling reactions. These complexes were …
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Synthesis of side-chain-modified mycothiol analogues incorporating carbazole quinones, and evaluation as inhibitors of enzymes in the Mycobacteria
… while the latter was unreactive in attempted Buchwald-Hartwig amination but successfully underwent reductive amination with a substituted benzaldehyde to give an advanced Abstract precursor of the target hybrid molecules. Compounds 38 and 40 together with similar analogues prepared in parallel …
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The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
… study. The final part of the thesis studies the Buchwald-Hartwig amination reaction used in the synthetic route leading to the best covalent ITK inhibitors. This coupling required 30 mol % of palladium catalyst, which, on large scale, represents a significant amount of metal waste. The …
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Continuous separation and recycle of homogeneous catalysts in small scale flow system
… a hydrogenation catalyst, and a palladium Buchwald-Hartwig amination catalyst. During the initial stages of designing such small scale catalyst recycle systems, significant technology gaps were identified. These included microfluidic OSN modules, microfluidic holding tanks with level …
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Regioselektive Synthese oxygenierter Carbazole
… benötigten N,N-Diarylamine konnten über die BUCHWALD-HARTWIG-Aminierung, die Eisensalzkomplexe über eine katalytische Komplexierung ausgehend von Cyclohexadienen mit Pentacarbonyleisen hergestellt werden. Beide Methoden wurden gegenübergestellt und besonders hinsichtlich ihrer Ausbeuten und …