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Showing 1 to 20 of 28 for “"Buchwald-Hartwig"”.
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Synthese halogenierter Carbazole und Totalsynthese der Amaryllisalkaloide Pratosin und Hippadin
… über den Palladiumvermittelten, bestehend aus Buchwald-Hartwig-Aminierung und oxidativer Cyclisierung, aufgebaut. Die Halogensubstituenten wurden entweder am Carbazol eingeführt oder bereits über die Startmoleküle in die Synthese eingebracht. Somit konnten verschiedene halogenierte halogenierte …
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Synthesis, Activation and Catalytic Activity of N-Heterocyclic Carbene Bearing Palladium Catalysts
… in cross-coupling (Suzuki- Miyaura, Buchwald-Hartwig) and related (catalytic dehalogenation, £-ketone arylation) reactions is also discussed. A comparison of the activity of a variety of (NHC)Pd complexes as pre-catalysts for cross-coupling reactions was carried out. The results …
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Development of Cobalt and Nickel N-Heterocyclic Carbene Complexes for Cross-Coupling Reactions
… reactivity in Negishi, Suzuki-Miyaura, and Buchwald-Hartwig amination cross-coupling reactions. Co(IPent)Cl2(Pyr), Co(IPentCl)Cl2(Pyr), and Co2IPr2(OAc)4 were prepared, identified by X-ray crystallography, and evaluated in preliminary Negishi cross-coupling reactions. These complexes were …
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New Cyclophanes as Supramolecular Scaffolds: The Synthesis of Tribenzo-1,4,7-Triazacyclononatriene.
… towards these molecules have employed both Buchwald-Hartwig palladium catalyzed N-arylation as well as benzyne chemistry. The synthesis of tribenzo-1,4,7-triazacyclononatriene and its derivatives will be discussed.</p>
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Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
… have analyzed and optimized Suzuki-Miyaura and Buchwald-Hartwig couplings reactions towards new derivatives of Tirapazamine. Allyl isothiocyanate (AITC) is a phytochemical that can be found in cruciferous vegetables and has received interest due to beneficial health effects. During our analyses …
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Regioselektive Synthese oxygenierter Carbazole
… benötigten N,N-Diarylamine konnten über die BUCHWALD-HARTWIG-Aminierung, die Eisensalzkomplexe über eine katalytische Komplexierung ausgehend von Cyclohexadienen mit Pentacarbonyleisen hergestellt werden. Beide Methoden wurden gegenübergestellt und besonders hinsichtlich ihrer Ausbeuten und …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… a porphyrin compound via reductive amination and Buchwald-Hartwig coupling reactions, giving four new examples of porphyrin-cyclen conjugates.A Suzuki coupling methodology has been used to synthesise a porphyrin-cyclen conjugate with an aryl-aryl linkage which exhibits enhanced stability towards …
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ARYL-HETEROATOM CROSS-COUPLING WITH DUAL NICKEL/PHOTOCATALYST PROTOCOLS : THEORY, APPLICATIONS AND RECENT DEVELOPMENTS
… common aryl-heteroatom cross-coupling protocols (Buchwald-Hartwig-, Ullmann- and Chan-Lam couplings) illustrating the general advantages and disadvantages of each cross-coupling method. The scope of different dual nickel/photocatalyst protocols are then explored, concentrating on cross-coupling of …
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The development of novel organocatalytic and transition-metal catalysed methodologies for amide bond formation
… corresponding nitriles as amide surrogates, a Buchwald-Hartwig amidation methodology has been developed, enabling the synthesis of secondary amides (Scheme 1.3). Investigations into the use of these species in other amide bond forming transformations have also been carried out.
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CATALYTIC BORYLATION OF C-H BONDS: A ROUTE TO PHOTOPHYSICALLY INTERESTING PYRENE DERIVATIVES
… further utilized in Suzuki-Miyaura, Sonogashira, Buchwald-Hartwig and Negishi cross-coupling reactions. Using this methodology, a library of 2- and 2,7-substituted pyrenes bearing donor and acceptor groups, including aryl, ethynyl, arylethynyl, alkyl, hydroxy, alkoxy, diarylamino, carboxylic acid …
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Naujų pirimidino - fenoksazino TADF spinduolių sintezė ir tyrimas /
… by a combination of Buchwald-Hartwig, Suzuki-Miyaura and Liebeskind-Srogl palladium-catalyzed cross-coupling reactions. Synthesis protocol and convenient methods of synthesis of 4,6-di[4-(10-phenoxazinyl)phenyl]-5-methyl-2-methyltiopyrimidines were elaborated. Eleven …
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INTRAMOLECULAR CARBON-NITROGEN COUPLING FROM ISOLATED MONOHYDROCARBYL PALLADIUM(IV) COMPLEXES PREPARED USING H2O2 AS TERMINAL OXIDANT
… amines through a Pd(0)/Pd(II) catalytic cycle (Buchwald-Hartwig amination). A newer, more atom-economical approach to the synthesis of amines is based on oxidative C-H amination. Recent studies of C-H amination propose the involvement of Pd(II)/Pd(IV) catalytic cycle through a C-H activation …
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Studies in palladium and rhodium catalysis: synthetic strategies for C–C bond formation
… can be expanded to enable a robust, one-pot Buchwald-Hartwig, C–H activation sequence to access biologically relevant indoloquinoline scaffolds from simple building blocks. In Chapter 2, rhodium-catalysed asymmetric conjugate additions are performed with indolyl boronic acids. The indole ring …
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Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
… efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered primary and secondary amines and b) coupling of 2-aminopyridine derivatives with aryl and heteroaryl halides. Although …
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Synthesis and Application of Air-Stable Secondary Phosphine Oxide, Oxime, and Amine-Phosphine Palladium(II) Complexes in Transfer Hydrogenation and Cross-Coupling Reactions
… the precatalysts were effective for the Buchwald-Hartwig amination of aryl bromides and aryl chlorides. We discovered that the identity of the amine ligand significantly impacts catalyst efficiency with linear primary alkyl amines providing the most active catalysts. A comparison study …
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Design and synthesis of polymeric semiconductors for perovskite applications
… approach; We found that utilizing the Buchwald-Hartwig amination protocol using primary aryl amines and aryl dihalides afforded highly reproducible, high yielding family of polymers, which could be purified by a simple sequence of precipitations. Appropriate selection of pendant …
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Machine-assisted synthesis and development in pharmaceutical industry
… in the reaction, a holistic modelling of Buchwald-Hartwig amine synthesis using DFT-based parameterisation techniques and a dozen machine learning algorithms led to development of highly predictive reaction models. Through several Explainable AI tools, reaction specific descriptors were …
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Controlling Site-Selectivity in Palladium-Catalysed Cross-Coupling Reactions using Non-Covalent Interactions Between Ligand and Substrate
… alkynes (Sonogashira coupling), anilines (Buchwald-Hartwig coupling) and electron-deficient arenes (Fagnou coupling) were all shown to be viable coupling partners, the latter representing a rare example of non-covalent interactions being used in conjunction with palladium-catalysed C-H …
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Design and synthesis of novel biologically active flavones and isoflavones
… was substituted with either aromatic systems via Buchwald-Hartwig crosscoupling or different benzyl moieties. Subsequent functionalization such as amination and demethylation further expanded the substrate scope of 3,4-disubstituted benzoxazines. The synthesis of aza-analogues of …
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Novel reaction discovery with rapid high-throughput experimentation via infrared spectroscopy and enzymatic electrochemical oxidation of alcohols
… reactions such as the Suzuki cross-couplings and Buchwald-Hartwig aminations. With deepened understanding of reagent selection and stereoselectivity of the catalyzed Petasis reactions from the HTS platform, we examined the possibility of electrochemical enzymatic catalysis. Galactose oxidase is …
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