Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Brugada"”.
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Modelling Brugada Syndrome using induced pluripotent stem cells
Objective: Brugada Syndrome is an autosomal dominant congenital heart disease that is responsible for 20% of sudden deaths of patients with structurally normal hearts. The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an …
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Cuantificación electrocardiográfica mediante métodos no lineales de análisis de señal. Valor diagnóstico y predictivo en el Síndrome de Brugada
El síndrome de Brugada (Sd. de Brugada) es una enfermedad hereditaria que cursa con un mayor riesgo de Muerte Súbita (MS). Esta población de pacientes es heterogénea y los síntomas, junto con el antecedente de una MS resucitada, son el factor predictor de MS más potente. Aun así, una parte …
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Effect of selected drugs on mitochondrial metabolism in an in vitro model of human skeletal muscle
… ECG changes that are similar to those of Brugada syndrome, hypertriglyceridemia, fever, hepatomegaly, rhabdomyolysis, cardiac and/or renal failure. The risk of the syndrome increases with raising dose and duration of propofol administration (˃48 hours). The mechanism of the syndrome is …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
… or channelopathies such as mutations leading to Brugada syndrome. BacNavs outperformed the endogenous channel in source-load mismatches due to increased action potential amplitude and slower inactivation kinetics. These conclusions were stable to spatial heterogeneity in the treatment. It was …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
Aberrations in conduction or repolarization are established prerequisites for arrhythmogenesis. The following dissertation investigates how reducing either ephaptic (EpC) or gap junctional (GJ) coupling between cardiomyocytes can modulate cardiac conduction, repolarization, or the relationship …