Global ETD Search
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Showing 1 to 5 of 5 for “"Bruchpilot"”.
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"Bruchpilot" -molecular and functional characterization of a novel active zone protein at the Drosophila synapse
… the first knockdown studies the gene was named “bruchpilot” (brp) encoding the protein “Bruchpilot (BRP)” (German for crash pilot). A pan-neuronal as well as retina specific downregulation of this protein results in loss of ON and OFF transients in ERG recordings indicating dysfunctional …
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Synaptic physiology of the developing <i>Drosophila</i> neuromuscular junction
… teilhaben. (1) Das neu entdeckte Protein Bruchpilot ist von essentieller Bedeutung sowohl für die strukturelle, als auch für die funktionelle Integrität von aktiven Zonen. Indem Bruchpilot die Nähe von Kalziumkanälen zu Vesikeln herstellt, bewirkt es die effiziente Freisetzung von …
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The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
… Par-1 kinase disrupt the transport of Bruchpilot- an essential active zone scaffolding protein in Drosophila and leads to its accumulation of BRP in axons at the expense of BRP at active zones. Ultimately, the loss of BRP at active zones results in reduced synaptic transmission. …
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Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
… subunit α2δ, and the core AZ scaffold protein Bruchpilot (BRP) in establishing a functional AZ. I find Cac and BRP are independently regulated at growing AZs, as Cac is dispensable for AZ formation and structural maturation, and BRP abundance is not limiting for Cac accumulation. Additionally, …
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Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation
… Lastly, western blot analysis showed restored bruchpilot (BRP) and tyrosine hydroxylase (TH) expression, referred to WT control levels. The results highlight multiple sites of action of Mpe and suggest that its effects cannot depend only upon its L-Dopa content; b) the effect of 1% Wse L-/A+ …