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Showing 1 to 10 of 10 for “"Brucella abortus strain RB51"”.
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
Brucella abortus is a zoonotic agent that primarily infects cattle and causes brucellosis. B. abortus strain RB51 is a live, attenuated vaccine licensed for cattle. However, there is no available vaccine to prevent human brucellosis. Outer membrane vesicles have been tested as potential vaccines to …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
Brucella abortus is amongst the top 5 zoonotic diseases worldwide. The overall goal of this research is to generate a safe and effective vaccine for humans. Brucella abortus strain RB51, approved for use in cattle, provides protection by initiating a strong T-helper 1 (Th1) type response is a …
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The Humoral Immune Response of Elks (Cervus elaphus nelsoni) and Mice to Vaccination with Brucella abortus Strain RB51
Vaccine Brucella abortus strain RB51, unlike the wild strain 2308 and another vaccine strain (strain 19) does not induce anti-O-chain antibodies. An efficacious vaccine strain that fails to produce an O-chain and thus a lack of an anti-O-chain humoral response greatly simplifies identification of …
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Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof
… would help in the development of a human Brucella vaccine and help in improving animal vaccines. In this research, B. abortus strain RB51 and a closely-related, nonpathogenic Ochrobactrum anthropi (strain 49237) bacterium were used to study the immune response against brucellosis in mice. …
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The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α
… in parallel having an effect on the killing of Brucella abortus strain RB51 by peritoneal macrophages, whereas neither TNFa nor Ab2f3 had an effect on the killing of strain 2308 by macrophages. These results, again indicate that TNFa and Ab2f3 have parallel dbactericidal effects and that Ab2f3 …
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Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
… study evaluated a recombinant vaccine with a Brucella abortus strain RB51 vector expressing the Mycobacterium bovis Ag85A. Striped bass (M. saxatilis) were inoculated at doses equivalent to 106, 107, 108, 109, and 1010 colony-forming units/fish. Vaccinated fish demonstrated significant …
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Effects of estrogen on the B cell functions of normal mice
… to nonautoimmune C57BL/6 mice, a widely used strain in immunology. In these mice, we found that treatment with estrogen, but not 5a-dihydrotestosterone. induced the expression of a wide variety of IgG and IgM autoantibodies and heteroantibodies that are associated with autoimmune and …
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Approaches towards vaccine development against Neospora caninum
… caninum research has been conducted with several strains of mice and the different strains of mice vary in their susceptibility to infection with N. caninum, there is a need to develop a standard lab animal model for N. caninum. A gerbil and a C57BL/6 mouse model for N. caninum vaccine testing …
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Increases in Cortisol due to Weaning Stress and the Subsequent Alterations to Immune Function in Beef Calves
… On day 0 all calves were vaccinated with Brucella abortus (strain RB51). Serum was analyzed for IFN? and IL-4 as well as IgG1 and IgG2 specific antibodies to RB51. Fecal samples were analyzed for cortisol metabolites. Both IgG1 and IgG2 antibodies to RB51 increased from day 0 to day 14 …
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Development of an Antibiotic Resistance Free Bivalent Vaccine Against Swine Brucellosis and Swine Influenza
… and viral origin. Swine brucellosis caused by Brucella suis and swine influenza caused by Influenza A virus affect both domestic and feral swine populations. Both the diseases have zoonotic potential to cause disease in humans with serious complications apart from inflicting huge economic …