Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Bronchoconstriction"”.
-
Dietary supplementation for the treatment of hyperpnoea induced bronchoconstriction in physically active asthmatics
… treatment for the condition. Exercise induced bronchoconstriction (EIB) is a term used to describe an acute asthmatic episode following exercise and is highly prevalent amongst asthma sufferers. Traditional treatment involves the use of pharmacological interventions, the long-term use of which …
-
The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction
INTRODUCTION: Exercise induced bronchoconstriction (EIBC) occurs as a result of airway cooling and drying in adults with airway hyperresponsiveness (AHR). Continuous exercise leads to a significant decline in lung function; however, interval exercise may allow ventilation to recover and prevent …
-
The prevalence of childhood asthma in white primary schoolchildren in the southern suburbs of Cape Town
… of 15% or greater was regarded as evidence of bronchoconstriction and considered diagnostic of asthma. This method is thought to identify 70-90% of asthmatics (Anderson 1985, Lee et al 1989, Pierson 1988). Using this criterion, 52 (4.4%) of the children had asthma. The prevalence of 4.4% in …
-
Sensory-Mechanical Responses to High-Dose Methacholine Bronchoprovocation: The Modulating Effects of Deep Inspirations
… p=0.022), dyspnea (Borg: 0.4±0.7; p=0.016), bronchoconstriction (%∆FEV1 -14.7±7.9%; p<0.001) and gas trapping (∆IC -0.20±0.36; p=0.001), compared to baseline. At MAX, the bronchodilation effect of DIs was preserved (DI index: 0.67±0.44 and -0.14 ± 0.15 at MAX and baseline, respectively; …
-
Mechanotransduction via airway epithelial cells : the effect of compressive stress
… stresses experienced by the epithelium during bronchoconstriction. The application of a transcellular pressure gradient (10-50cmH20) for 10 minutes resulted in transient activation of the epidermal growth factor receptor (EGFR) - MAP kinase (ERK) signaling pathway. Furthermore, specialized …
-
Existence of patchiness in constricted lungs : from experiments to complex system modeling
… features several attempts to study mechanisms of bronchoconstriction and interdependence between respiratory structure and function. First, with complex system modeling of a network of airways, I investigated the effect of breathing patterns on the catastrophic closure of airways and the emergence …
-
Development and Resolution of Pulmonary Arterial Hypertension in RAO Horses
… (RAO) is associated with airway inflammation and bronchoconstriction in clinically affected horses. Horses demonstrating severe pulmonary compromise develop concurrent secondary pulmonary hypertension. The development of pulmonary hypertension is well documented in RAO affected horses, however, it …
-
Studies on the role of the autonomic nervous system in airway hyperreactivity.
… are altered after sensitization. Vagal bronchoconstriction was attenuated in vivo by cromakalim in untreated and sensitized animals to the same degree but no direct bronchodilator effect was apparent. Verapamil and TFP also attenuated vagally-mediated responses in sensitized and …
-
Comparison of Airway Response in Recurrent Airway Obstruction-Affected Horses Fed Steamed Versus Non-steamed Hay
… Obstruction (RAO)-affected horses experience bronchoconstriction and airway inflammation in response to inhalation of irritants including hay molds. Steaming hay reduces fungal content, but the effect on the antigenic potential has not been investigated. We tested the hypothesis that …
-
Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation
… (RAO) affects middle-age horses, inducing bronchoconstriction and airway inflammation. β2-agonists like salbutamol are used as treatment, promoting airway smooth muscle (ASM) relaxation and bronchodilation. In addition to ASM, inflammatory cells express the β2-adrenoreceptors (β2-AR). In …
-
Numerical Analysis of Respiratory Aerosol Deposition: Effects of Exhalation, Airway Constriction and Electrostatic Charge
… II: In order to evaluate the effects of bronchoconstriction under exhalation conditions, normal and constricted pediatric airway models were considered. Results include (i) a significant increase in deposition for constricted airways, and (ii) a novel correlation for deposition during …
-
Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… lipid mediators involved in mucus production, bronchoconstriction and leukocyte migration, and act via the receptors CysLTiR and CysLT2R. Recently, CysLTs have been implicated in Th2 responses in mouse models, although the exact mechanisms are unclear. Preliminary microarray studies on …
-
The impact of pathological ventilation on aerosol deposition : imaging, insight and intervention
… used analytical tools and an in-silico model of bronchoconstriction to illustrate the emergence of pendelluft gas transport between parallel regions of the lung. We found that though pendelluft may emerge in asthma, the overall volume passed between parallel regions of the lung is likely less …
-
Comparing exercise responses to high intensity interval training between adults with and without asthma
Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated with reductions in inflammation, improvements in cardiorespiratory …
-
Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… activity to airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyperresponsiveness through G-protein coupled receptor, cysteinyl leukotriene receptor 1(CysLTR1). CCL2 (MCP-1, Monocyte Chemoattractant protein-1) is one of the major chemokines responsible for …
-
Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
… improves muco-ciliary clearance, decreases bronchoconstriction, and modulates pulmonary immunity. Surfactant alterations in human asthma are therefore believed to contribute to the severity of airway obstruction. The goal of our first study was to characterize surfactant phospholipid …
-
Ergogenic Effects of Intake of Salbutamol, Caffeine and Theobromine on Non-Asthmatic Subjects
… in the treatment of asthma, exercise induced bronchoconstriction (EIB) and airway hyperresponsiveness (AHR). The World Anti-doping Agency (WADA) permits asthmatic athletes to use inhaled salbutamol with an accumulated dosage not exceeding 1600 µg over a 24-hour period. A key driver for the …
-
Evaluation of the Effect of Critical Process and Formulation Parameters on the Attributes of Nanoparticles Produced by Microfluidics. Design of Experiments Approach for Optimisation of Process and Formulation Parameters Affecting the Fabrication of Nanocrystals of Poorly Water-Soluble Drug Using Anti-solvent Precipitation in Microfluidic
… β2-agonist for quick relief of acute bronchoconstriction due to its long onset of action. This lack of the ‘kick’ effect in SAL can be attributed to its relatively higher lipophilicity which causes a delay in the diffusion to the β2 receptors on the smooth muscles. It is therefore …
-
Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
… in aspirin hypersensitivity as it can induce bronchoconstriction and bronchohyperresponsiveness. TBXA2 exerts its action by interacting with the G protein-coupled thromboxane A2 receptor (TBXA2R). Based on previous association of TBXA2R with asthma and atopy, we investigated whether genetic …
-
Assoziation zwischen bronchialer Inflammation und anstrengungsinduzierter Bronchokonstriktion bei Kindern mit Asthma bronchiale
Ziel der Studie war es, in einem Kollektiv von Asthmatikern mit eosinophiler Bronchialinflammation einen möglichen Zusammenhang zwischen Atemwegsinflammation und AIB zu untersuchen. <br>An der Studie nahmen 42 Kinder zwischen 6 und 14 Jahren mit mildem bis mittelschwerem Asthma bronchiale teil. …
Page 1 of 2