Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Bronchoalveolar Lavage Fluid"”.
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Utility of newer and novel technologies for the diagnosis and treatment-monitoring of tuberculosis using different biological fluids
… other than sputum such as blood, urine and bronchoalveolar lavage fluid, are thus increasingly being used for diagnostic purposes. However, there is a low yield of rapid diagnostic tools, and the use of recently released commercially available technologies for tuberculosis diagnosis requires …
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Immune Dysfunction in Cystic Fibrosis
… show increased cytokine expression in sputum and bronchoalveolar lavage fluid samples in CF patients. To determine if this is secondary to the chronic inflammatory environment of the lungs or innate to CF immune cells itself, leukocytes were isolated from peripheral blood and stimulated with LPS …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… biomarkers in exhaled breath condensate (EBC), bronchoalveolar lavage fluid (BALF), red blood cells, white blood cells, and plasma; and cytokine expression in airway inflammatory cells and mucosal biopsies of RAO-affected horses and their controls. Sixteen horses in pairs were used: 8 …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… increased cellular infiltrate in their bronchoalveolar lavage fluid, decreased vimentin and N-cadherin with increased expression in E-cadherin in the epithelium compared to HRA mice on a vitamin D-sufficient diet. Finally, vitamin D-deficient HRA mice were analyzed for the effect of …
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Effects of mannan oligosaccharide on immune function and disease resistance in pigs
… in peripheral blood mononuclear cells and bronchoalveolar lavage fluid cells at d 7 PI was characterized by using microarray and real time RT-PCR. The MOS x PRRSV interaction altered the gene expression in the above leukocytes (P < 0.05). In peripheral blood mononuclear cells, MOS increased …
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Comparative efficacy of three common treatments for equine recurrent airway obstruction
… clinical parameters, pulmonary function testing, bronchoalveolar lavage fluid (BALF) cytology and BALF cell expression of the cytokines IFN-? and IL-4 Animals - 6 horses with recurrent airway obstruction (RAO) Procedures - Clinical examination, pulmonary function test, and collection of BALF prior …
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Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
… pathogenesis. Elevated levels of 15(s)-HETE in bronchoalveolar lavage fluid (BALF) were demonstrated in severe asthmatics and aspirin-exacerbated respiratory disease (AERD). To investigate genetic contribution of ALOX15 in the development of AERD, we performed the genetic association of ALOX15 …
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Novel and newer nucleic acid amplification tests for the diagnosis of TB
… MTB/RIF (Xpert) test on non-sputum specimens (bronchoalveolar lavage fluid [BALF], tracheal aspirates, and cerebrospinal fluid [CSF]) from South African patients with suspected TB (the accuracy of Xpert using these fluids was unknown at the time this work was performed). Methodology: Biological …
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EXPLORING EQUINE ASTHMA: PATHOGENESIS INSIGHTS AND DIAGNOSTIC CHALLENGES
… MEA, correlating with increased neutrophils in bronchoalveolar lavage fluid. In racehorses, while EA did not appear to be linked with dynamic upper airway obstructions, it did show an association with impaired athletic capacity in cases of neutrophilic inflammation. Oscillometry studies proved …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… phenotype in lipopolysaccharide or ARDS patient bronchoalveolar lavage fluid-treated human macrophages. This phenotype was characterised by a dampened inflammatory cytokine secretory profile, increased expression of the classical M2 macrophage marker CD206 and enhanced phagocytic capacity. …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… circulation and total leukocyte count in the bronchoalveolar lavage fluid. Lastly, in a balloon-induced femoral artery injury model of thrombosis in hypercholesterolemic rabbits, PF-04886847 reduced thrombus mass and prolonged both prothrombin time (PT) and activated partial thromboplastin …
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Responses of respiratory system cells in vitro and in vivo to petrochemical combustion-derived ultrafine particles
… pathways. We also present an in vivo analysis of bronchoalveolar lavage fluid (BALF) with inflammatory cell infiltrates, histopathological evidence of inflammation and particle retention, and gene expression analysis revealing upregulation of several cytokines and AhR-responsive biotransformation …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… cells were compared in peripheral blood (PB) and bronchoalveolar lavage fluid (BALF) of children with chronic bronchitis and interstitial lung diseases. Methods: BAL was performed in 70 children. According to clinical, macroscopic and cytological findings 37 children were selected for the study …
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THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
… damage by measuring malondialdehyde in bronchoalveolar lavage fluid. The results showed that acrolein-induced respiratory toxicity had considerable effects on airway remodeling measured by mechanical pulmonary testing, with a significant increase in respiratory resistance, a decrease in …
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Rapid tests for fungal infection in critical care
… accuracy of serum BDG and Aspergillus PCR in bronchoalveolar lavage fluid (BALF) and serum, using a galactomannan-based definition as a reference standard, suggestedthat BDG had the greatest sensitivity of these tests and serum PCR had the greatest specificity. Given its sensitivity, BDG may …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… models, cigarette smoke or hyperoxia. Mouse bronchoalveolar lavage fluid (BALF) was assayed for oxidative damage to compare age, genotype, and exposure; fixed lungs were sectioned, stained, and the morphology examined. Next, exogenous Klotho was incorporated into poly-lactic-co-glycolic-acid …
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Identification of Lung Carcinoma Biomarkers Associated with Tumour Development and Drug Resistance
… such as proteins and metabolites, in biological fluid or tissue/cells could potentially detect cancer at an early stage, determine cancer subtype, or monitor the sensitivity/resistance to cancer treatment. The research in this thesis aims to discover new biomarkers, using proteomic techniques, …
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Role of Fas/FasL, inflammatory mediators and LPS-activated macrophages in human neutrophil apoptosis
… contribute to the pools of sFasL found in the bronchoalveolar lavage fluid (BALF) in ARDS patients. We have shown that the conditioned supernatants from LPS-activated macrophages induced neutrophil apoptosis at early time points. The pro-apoptotic activity was mediated by TNF-α and was found in …
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Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
… and to investigate the influence of age and bronchoalveolar lavage fluid (BALF) sample characteristics on surfactant. For that purpose, BALF was collected from 17 healthy horses and evaluated for BALF recovery percentage, cell count, and cell differential. BALF was separated into crude …
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PULMONARY ARTERY STIFFNESS IN RACEHORSES AFFECTED BY EXERCISE-INDUCED PULMONARY HEMORRHAGE
… the agreement between tracheal wash (TW) and bronchoalveolar lavage fluid (BALF) for EIPH assessment was evaluated in 172 poorly performing racehorses. TW and BALF provided similar information when hemorrhage was quantified using hemosiderophage-based metrics. A simplified TW Total Hemosiderin …
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