Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 638 for “"Broad-spectrum"”.
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Broad-Spectrum Synthesis of Enantiomerically Pure Lactones
A general synthetic approach that affords both enantiomers of chiral lactones is described. The key step involves the automated multigram chromatography of diastereomeric derivatives of a racemic intermediate. The generality of the method is demonstrated by the synthesis of ring-saturated lactones …
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Development of Small Molecules as Broad-spectrum Filoviral Entry Inhibitors
… in filoviral entry. In the effort to develop broad-spectrum antifilovirals, a series of N-substituted pyrrole-based heterocycles and elacestrant derivatives were developed to target GP and effectively inhibit diverse filoviral entry in a pseudovirus assay. Selectivity, potency, and metabolic …
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Characterization of the Broad-Spectrum Racemase, BsrF, in Vibrio fischeri
… and their roles are still being elucidated. Broad-spectrum racemases (Bsr), which have been found in several Bacteria and one Archaeon, can catalyze the interconversion of L- and D-isoforms. These Bsrs have a wide range of possible substrates and differ from each other in several ways, such …
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Exploiting rice diversity to uncover durable and broad-spectrum resistance
… respectively. This study aims to identify novel, broad-spectrum and durable sources of resistance to BB and BLS, and to pinpoint potential candidate genes for further characterization. We screened an indica rice Multi-parent Advanced Generation Inter-Cross (MAGIC) population, a novel mapping …
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Phosphoethanolamine methyltransferases inhibitors with broad-spectrum anthelmintic effect against livestock nematodes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… pandemic has highlighted the critical need for broad-spectrum antiviral therapeutics capable of addressing current and future viral outbreaks. Coronaviruses, particularly SARS-CoV-2, continue to pose significant public health threats due to their zoonotic origin, adaptability, and rapid spread. …
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Computational Methods to Design Broad-Spectrum Medical Countermeasures Against Antigenically Diverse Pathogens
… and deep learning methods, can be used to design broad-spectrum vaccines and antibodies that are effective against a wide range of pathogen variants. I focus on two complementary projects: 1) designing single-antigen vaccines to induce broad-spectrum T-cell responses, and 2) developing a deep …
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Development of a Broad Spectrum, Sporicidal, Cost Saving Disinfectant Incorporating a Novel Antimicrobial Catalyst
Introduction: Hospital infections are still a major burden within the health care sector. Without adequate infection control procedures such as hand washing and disinfection, this can lead to morbidity and mortality in the extremely ill or immunocompromised patients. A novel heterogeneous …
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Ring distortion of the alkaloid sinomenine and novel prodrug approaches to broad-spectrum antibiotics
… the major limitation of discovering new broad-spectrum antibiotics: passage across the outer membrane, and ultimately accumulation. The chapters herein emphasize the importance of combating antibiotic resistance, specifically against Gram-negatives, and provide actionable strategies by …
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On the development and application of a photon counting imaging system for broad spectrum luminescence analysis
… the Photon Counting Imaging System (PCIS), with broad spectrum high sensitivity imaging capabilities, incorporating both thermal and multi-source optical stimulation, and providing flexible facilities for the optical filtering of signals, was designed and constructed. Capable of high quantum …
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On the development and application of a photon counting imaging system for broad spectrum luminescence analysis
… the Photon Counting Imaging System (PCIS), with broad spectrum high sensitivity imaging capabilities, incorporating both thermal and multi-source optical stimulation, and providing flexible facilities for the optical filtering of signals, was designed and constructed. Capable of high quantum …
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Digital immunoassay for rapid detection of SARS-CoV-2 infection in a broad spectrum of animals
The student, Siyan Li, accepted the attached license on 2024-12-11 at 14:36.
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… replication, making it an ideal target for a broad-spectrum inhibitor of the related viral proteases.
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Broad Spectrum Methods for the Resolution of Optically-Active Compounds--Application to the Synthesis of Natural Products
Made available in DSpace on 2014-12-13T20:10:12Z (GMT). No. of bitstreams: 1 7804019.pdf: 4454246 bytes, checksum: a67bffbe20e0a11436e4a3ea06dfab32 (MD5) Previous issue date: 1977
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The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug
… of new anti-infective drugs. Host-Oriented Broad-Spectrum (HOBS) treatments have the promising potential to alleviate these problems. The HOBS treatment paradigm focuses on finding drug targets in human host that are simultaneously effective against a wide variety of infectious agents and …
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Identification and analysis of mechanisms involved in a broad-spectrum disease resistant mutant of the winter wheat cv. Guardian
… wheat (Triticum aestivum) cv. Guardian exhibits broad-spectrum resistance to powdery mildew (Blumeria graminis f. sp. tritici), yellow rust (Puccinia striiformis f. sp. tritici), and leaf rust (Puccinia recondita f. sp. tritici), along with partial resistance to stagnonospora nodorum blotch …
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Hunting Specialisation and the Broad Spectrum Revolution in the Early Epipalaeolithic: Gazelle Exploitation at Urkan e-Rubb IIa, Jordan Valley
… explores the impact of Flannery’s (1969) Broad Spectrum Revolution model within the context of the Levantine Epipalaeolithic, specifically the early (Kebaran) Epipalaeolithic. This model attempts to explain changes in subsistence behaviour associated with the end of the Pleistocene leading …
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Understanding the determinants for substrate recognition, regulation of enzymatic activity and the development of broad-spectrum inhibitors of coronavirus 3-chymotrypsin-like proteases
… that can be utilized for the development of broad-spectrum anti-coronaviral therapeutics. Viral encoded 3-Chymotrypsin-like protease (3CLpro) is essential for viral polyprotein processing to release non-structural proteins that form the replicase complex machinery for viral genome …
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