Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Brevetoxins"”.
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
<p>Brevetoxins are natural neurotoxins that are produced by "red tide" algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography (LC) coupled with …
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Development of Novel Liquid Chromatography-Electrospray Tandem Mass Spectrometry Approaches for the Structural Characterization of Brevetoxins Including in vitro Metabolites
Brevetoxins are natural neurotoxins that are produced by “red tide†algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography-electrospray mass …
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Isolation and characterisation of toxins from Fibrocapsa japonica (Raphidophyceae)
… produced by this alga) were ever reported e.g. brevetoxins, but not acceptable for lack of conclusiveness. In this work, the toxicity of Fibrocapsa japonica algal cells was first established by Artemia salina biotest. Fibrocapsins was screened step by step through Artemia salina biotest, …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… (PbTx-2) to mimic neuronal activity. Brevetoxins interact with binding site 5 on the α subunit of VGSCs. PbTx-2 was found to increase intracellular sodium concentration ([Na+]i) in immature cerebrocortical neurons above the critical threshold for upregulating NMDAR function. Hence …