Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Breast tumor cells"”.
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
… chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
On normal blood vessels, vascular mural cells (pericytes and smooth muscle cells) serve to stabilize the vessel and render the endothelium quiescent. Tumor vessels, in contrast, exhibit abnormal association between mural cells and endothelial cells which allows the endothelium to be angiogenic. The …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
… agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor agents that are effective against breast cancer based on structures derived from marine organisms, …
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Development of Natural Cyclic Peptide Inhibitors of XRCC4/XLF Interaction for Radio-Sensitization of Breast Tumor Cells
Breast cancer is the second leading cause of cancer death in women according to the American Cancer Society. The standard treatment regimen for breast cancer involves ionizing radiation combined with surgery and chemotherapy. Ionizing radiation induces a complex signaling response in cells …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell death in part through the inhibition of …
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Role of protein kinase C isoforms in human breast tumor cell survival
… to identify specific PKC isoforms that promote breast tumor cell survival following radiation treatment. This work demonstrated that depletion of PKC delta and PKC zeta isoforms from MCF-7 and MDA-MB-231 human breast tumor cells by antisense oligonucleotides significantly impaired survival …
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Radiation Sensitization of Breast Cancer Cells by Vitamin D Through the Promotion of Autophagic Cell Death
… the first line of treatment for cancers of the breast. While radiotherapy is often initially effective in killing tumor cells or suppressing their growth, there are factors that confer tumor cell resistance to irradiation. Development of resistance may lead to disease recurrence despite the use …
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Microfluidic Platforms for Investigating Cell Migration
… ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic mammary epithelial tumor cells MDA-MB-231. These investigations show that increased …
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… in the nucleus and/or in the cytoplasm of human breast tumor cells. This pattern of localization is similar to that of another forkhead family member, FOXO3a. Additionally, localization of FOXO3a is known to be differentially regulated by upstream kinase AKT. Therefore, I investigated whether …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… survival rate post-diagnosis, secondary tumors to the brain are a leading cause of cancer-related deaths. Understanding the mechanisms of tumor cell extravasation at the brain is therefore crucial to the development of therapeutic agents targeting this step in cancer metastasis, and to …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… however is associated with an increased risk of breast cancer, an effect that has been attributed to the progestin component, the most common of which is medroxyprogesterone acetate (MPA). It is likely that breast cancers arise due to progestin-dependent release, from breast tumor cells, of …
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Exploiting Clausius-Mossotti Factor to Isolate Stages of Human Breast Cancer Cells: Theory and Experiment
… dielectrophoresis (cDEP) for isolation of breast cancer cell stages. The ability to selectively concentrate breast tumor cells from a non-transformed or normal cell population is the key to successfully detecting tumors at an early stage of growth and treating transformed cells before they …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
<p>Breast cancer brain metastases have remained one of the most intense challenges for precision cancer therapeutics, but current treatment options are limited and not curative. Recently, our lab reported that adoptive <em>PTEN</em> downregulation in metastatic breast tumor cells activates …
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Identification of differentially expressed genes in breast cancer tissues and cells
Breast cancer, is the second leading cause of cancer related deaths among women in developed countries, and the incidence of morbidity and mortality is rising in developing countries. The purpose of this project was to utilize the differential display technique to identify genetic changes in normal …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… in vitro by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and cell-ECM adhesion in the formation and polarization of the apical junction complexes in normal mammary epithelial …
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Urinary Volatile Organic Compounds for Detection of Breast Cancer and Monitoring Chemical and Mechanical Cancer Treatments in Mice
… is to identify metabolic transformations in breast cancer through urinary volatile organic compounds in mammary pad or bone tumor mice models. Subsequently, it focuses on investigating the efficacy of therapeutic intervention through identified potential biomarkers. Methods for monitoring …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… to maintain or enhance quality of life in breast cancer patients. Recent epidemiological studies indicate that aerobic exercise following a diagnosis of breast cancer may be associated with reductions in cancer-specific and all-cause mortality. However, the mechanisms by which physical …