Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Breast carcinomas"”.
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A comparison of mechanical models for the viscoelastic response of human breast carcinomas
… Force Microscope reveals that isolated human breast cells do not exhibit simple exponential relaxation capable of being modeled by the Standard Linear Solid (SLS) model. Therefore, this work proposes the application of a progression of more sophisticated models that may extract the mechanical …
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Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas
Breast cancer management continues to be a challenge due to the heterogeneity of the disease and the fact that individuals with the same stage and pathological diagnosis may respond differently to treatment as a result of differences in gene expression. Several components of the Her-2/PI3K/Akt …
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Investigation of the role of Platelet-Derived Growth Factor (PDGF) in the development of breast carcinomas
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, September 2002.
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Application of radioisotope imaging and therapy in patients with breast carcinomas that express the sodium iodide symporter gene
… which can concentrate all isotopes of iodine. Breast cancer is the most common type of cancer in women in the UK, and is the second most common cause of cancer-related death in women in the UK. This situation remains true in Scotland, with breast cancer representing 27.5% of all female cancers. …
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either increase or decrease the transcriptional activity of Dmp1 depending the molecular contexts of the targeted genes. Although loss of Dmp1 significantly accelerated oncogenic neu induced mammary carcinogenesis in …
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The recruitment of stromal cells to the site of tumor formation
… cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting angiogenesis and invasion, and we therefore sought to better understand how myofibroblasts are incorporated into breast carcinomas. By …
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Family and tumour studies in breast and oesophageal cancer
… was the genetic analysis of a recently mapped breast cancer susceptibility locus, BRCAl, in a number of breast and breast-ovarian cancer families. In the largest of the ICRF families studied (BOV3), linkage to the long arm of chromosome 17 was confirmed and a number of recombinants were …
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Measurement of physiological variables by dynamic Gd-DTPA enhanced MRI
… in two angiogenesis dependent diseases: breast cancer and rheumatoid arthritis (RA). In a study involving QDEMRI analysis of 59 primary invasive breast carcinomas, a significant relationship between capillary permeability-related QDEMRI variables and tumour grade was found. In a …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… family members are often over-expressed in human breast carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with Lapatinib undergo G1 phase arrest, followed by apoptosis. …
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… analysis of primary HER2-positive breast carcinomas (BCs) treated with adjuvant trastuzumab identified a tumour subgroup, characterised by high <i>ERBB2</i>/low <i>ESR1</i> expression, with good clinical outcome, and allowed the development of a trastuzumab risk model (TRAR) able to …
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Joint Network Modeling of Omics Data for Understanding Complex Diseases
… the effect of neoadjuvant therapy in breast carcinomas, I identify potential mechanisms for disease progression and treatment response. In summary, throughout this thesis I develop a range of statistical techniques to study biological networks derived from omics data, with applications …
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Elucidating The Role of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment
… analyze the stromal incorporation within murine breast carcinomas (EO771 and 4T1). Subsequent tumors were analyzed for vessel formation (CD31), and the presence of tumor associated fibroblast (TAF) markers, α-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), and fibroblast …
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Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential
… are major carriers of altered glycans in most carcinomas, and mainly belong to the MUC family, with MUC1 considered one of its most prestigious affiliates, as it is<br/>upregulated and aberrantly glycosylated in the majority of breast and many other<br/>adenocarcinomas. The large domain of the …
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Roles of the ING1 Epigenetic Regulator in Breast Cancer
… as a therapeutic agent and prognostic marker for breast cancer. We began by asking whether dysregulating epigenetic pathways with different chemical inhibitors could show synergistic effects with ING1 on killing cancer cells. We tested whether ING1 could synergize better with chemotherapeutics …
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
… as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditions chemo- and …
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Y-box binding protein-1 (YB-1) is essential for the growth and survival of HER-2 over-expressing breast cancer cells
… receptor (HER-2) is over-expressed in 20-30% of breast carcinomas and is a prognostic marker for poor patient outcome. We previously identified the transcription/translation factor Y-box binding protein-1 (YB-1) to be a novel substrate of AKT which binds to epidermal growth factor receptor (EGFR) …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was also to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological …
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Trim24 As An Oncogene In The Mammary Gland
<p>Despite the many advances made in breast cancer research and treatments, breast cancer remains one of the deadliest diseases plaguing women worldwide. While many findings on genetic mutations and their role in predisposing people to breast cancer have been uncovered, we are just beginning to …
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… were reported to recapitulate human Metaplastic Breast Carcinomas (MpBC).</p> <p>Furthermore, in our earlier research on TRIM24 overexpressing mammary cancer epithelial cell lines, our lab also showed that knocking down TRIM24 using siRNA results in significantly impaired cell growth and …
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
Globally, breast cancer is the most common cancer affecting women and it is predicted that in 2030 about 12 million deaths will occur with approximately 21.7 million new cases. Genetic risk factors as well as race and ethnicity, account for about 5-10% of all breast cancer occurrences. Triple …
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