Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Breast carcinoma"”.
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Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
… is known only in lymphoma, non-small cell lung carcinoma, and malignant gliomas. The functional expression of LRF in human breast carcinoma has not been confirmed. The aim of this study was to investigate the expression of LRF and propose a mechanism for its function in human breast carcinoma. …
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Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… in the response to acidic pH in ductal carcinoma in situ (DCIS). We have found that STAT1-directed signaling is up-regulated in response to acidic pH extracellularly. Its role in altering glycolytic pathways suggests an important role for this transcription factor in the development of …
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A study to investigate the role of P27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma
… immunoexpression as a prognostic factor in early breast carcinoma. Cyclin E and p27 immunohistochemistry was performed on sixty six cases of breast carcinoma submtted over a five year period to the Division of Anatomical Pathology, Groote Schuur hospital; Whittaker and Associates; and PathCare. …
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Detection of human papillomavirus (HPV) and expression of cell-cycle markers in breast carcinoma in a cohort of South African patients
Breast carcinoma is a common cancer in South African women. In the Republic of South Africa, 41 new cases of breast cancer are diagnosed per 100 000 population and the mortality rate is 21 per 100 000 population. Many risk factors have been implicated in the carcinogenesis of this disease; …
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The Effects Of Curcumin On The Expression Of P53 And Bcl-2 Oncoproteins On The Human Breast Carcinoma Cell Line MDA-MB 468
… on the proliferation and viability of MDA-MB-468 breast cancer cells and its effects on the expression ofBcl-2 and p53 proteins in these cells. Based on previous studies, we predicted a dose-dependent increase in p53 (tumor suppressor) expression, and a decrease in Bcl-2 (anti-apoptotic …
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Five-year review of breast-conserving therapy (BCT) for breast carcinoma: Surgical margins, re-excision and local recurrence in a single tertiary center
Background: Breast cancer burden is on the increase in the developing world. Breast-conserving therapy (BCT) is prescribed for early breast cancer. It is the wide local excision of the tumour usually followed by radiation treatment to the breast. It is the mainstay treatment for carefully selected …
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Krūties carcinoma in situ tipai, diagnostika, gydymas ir prognozė /
SUMMARY Carcinoma in situ is a non-invasive form of breast cancer characterised by abnormal cell growth in the ducts or lobules of breast tissue. Breast carcinoma in situ consists of two subtypes: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Breast carcinoma in situ is most …
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Biological Potencies and Mechanism of Action of Estrogens and Antiestrogens in Primary Cell Cultures of Human Endometrium and in Mcf-7 Human Breast Carcinoma Cells in Vitro
Primary cultures of human endometrial cells were used to examine the direct effects of estrogens on progesterone receptor levels in vitro. Cells, grown in Dulbecco's EMEM, showed maximal stimulation of progesterone receptor (PR, 7-fold) after a 3-4 d incubation with 10nM estradiol (E(,2)). The
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
Globally, breast cancer is the most common cancer affecting women and it is predicted that in 2030 about 12 million deaths will occur with approximately 21.7 million new cases. Genetic risk factors as well as race and ethnicity, account for about 5-10% of all breast cancer occurrences. Triple …
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The use of lymphoscintigraphy to localise the sentinel lymph node
… is being used increasingly for staging early breast carcinoma in place of complete axillary lymph node dissection. The optimal method to identify the SLN and has not been clearly elucidated in the literature. A number of techniques have been proposed for identifying SLN/s. The main debate …
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International Academy of Cytology Yokohama System for reporting Breast Fine Needle Aspiration Biopsy (FNAB) cytology: A Retrospective Study in a Single South African Tertiary Institution
Introduction: Breast carcinoma is the most common malignancy amongst women in South Africa. Triple assessment has been pivotal in the work up and management of breast carcinoma. Breast cytology has been used as a component of the triple assessment. Although core needle biopsy (CNB) is the gold …
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ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… that TAp73 isoform was highly expressed in human breast cancer as compared to the normal tissue. Therefore, this project aims to elucidate TAp73 functions in breast cancer development. Using three cell type-specific TAp73 knockout MMTV-PyMT mouse breast carcinoma mouse model, our results suggested …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… diagnostic and therapeutic drug design for human breast carcinoma. Molecular probes, such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better understanding of ER localization, structure, and function. We have prepared two fluorinated …
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Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas
Breast cancer management continues to be a challenge due to the heterogeneity of the disease and the fact that individuals with the same stage and pathological diagnosis may respond differently to treatment as a result of differences in gene expression. Several components of the Her-2/PI3K/Akt …
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The platelet laminin receptor : discovery of a 67kDA receptor for laminin on the membranes of human platelets : characterisation and isolation
… It is abundantly expressed on the membranes of breast cancer cells, where it plays a key role in both the localisation at, and penetration of vascular beds, by metastases. The objectives of this study were: * The development of a micro-titre assay similar to those used in previous studies, …
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Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α
… clinical chemotherapy agents are not ideal for breast cancer as they are not curative, but only provide a modest extension of survival with sometimes a severely adverse effect on the patient’s quality of life. There is, therefore, an urgent need to search for new and more effective anti-breast …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
<p>Breast cancer is the most common type of cancer among women in the US. Phytoestrogen resveratrol (RS V) has been described as a potential ehemotherapeutic agent, but has been associated with breast cancer cell growth and cell death. RSV binds to estrogen receptors (ER) and functions as a mixed …
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