Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Breast cancer tissue"”.
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Development of supervised and unsupervised pixel-based classification methods for medical image segmentation
Breast cancer is among the well-researched type compared to other common types of cancer. However, there still remain important open issues for investigation. One of these issues is the clarification of the importance of certain biological factors, such as histological tumour grade and estrogens …
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Development Of Isotags For Nmr Based Metabolite Profiling And Applications
… a study on metabolite profiling using intact breast cancer tissue samples in which we exploit the combined strength of NMR and multivariate statistical methods for metabolite profiling.</p>
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Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)
Tissue biology involves an intricate balance between cell-intrinsic processes and interactions between cells organized in specific spatial patterns, which can be respectively captured by single-cell profiling methods, such as single-cell RNA-seq (scRNA-seq), and histology imaging data, such as …
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Multiple Levels of Regulation of Cyclin-dependent Kinase Inhibitor 1A (p21/WAF-1) by the <i>DDX5 </i>Gene
… of the DDX5 lncRNA, p68 and p21 proteins in breast cancer tissue, that these gene products may differentially regulate p21 levels and that the DDX5 gene may exhibit multiple mechanisms to control p21 expression. In addition, through Pulse SILAC proteomics and western blot validation I have …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… neoadjuvant treatment for locally advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients who would benefit, thus maximising treatment efficiency. This project aimed to identify predictive protein …
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A “Zero-Background” Multiplexed, Point-Of-Care Testing Platform for Disease Diagnosis, Management, and Surveillance
… test for molecular and cellular credentialing of breast cancer tissue at the POC (Chapter 2). With the onset of the coronavirus 2019 (COVID-19) pandemic, we adapted the platform to detect several different relevant biomarkers for COVID-19, including total antibody concentration against several …
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Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity
… REGULATION OF MAP KINASE PHOSPHATASES 1 and 2 IN BREAST CANCER TAMOXIFEN SENSITIVITY</strong> </p> <p>by</p> <p> <strong>KELLY K. HAAGENSON</strong> </p> <p> <strong>May 2013</strong> </p> <p> <strong>Advisor:</strong> Dr. Malathy Shekhar</p> <p> <strong>Co-Advisor:</strong> Dr. Gen Sheng Wu</p> …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer …
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Molecular vibrational diagnostics - from quantum state stability to real time histopathology
… analysis of histological sections, resected tissue specimens, or in situ tissue are highly desired for early disease diagnosis. Stained histopathology is the gold standard, but remains a subjective practice on processed tissue taking from hours to days. We present proof of principle results …
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Identification of novel biomarkers for clinical prognosis in breast cancer
… signalling is up-regulated in numerous human cancers (e.g. stomach cancer, colon, rectal, glioblastoma, ovarian, renal, lung and breast) making S1P signalling an important candidate as a biomarker and a key player in promoting cancer progression. Several inhibitors of SK/S1P signalling pathway …
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Application of radioisotope imaging and therapy in patients with breast carcinomas that express the sodium iodide symporter gene
… in the thyroid gland. Differentiated thyroid cancers retain the appearance and function of normal thyroid cells, and can, therefore, trap iodine. Radioiodide scintigraphy and therapy are based on the uptake of radioiodide by NIS in thyroid tissue, which can concentrate all isotopes of iodine. …
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Deciphering the Functions of Ets2, Pten and p53 in Stromal Fibroblasts in Multiple Breast Cancer Models
Breast cancer is the second most common cancer in American women, and is also the second leading cause of cancer death in women. It is estimated that nearly a quarter of a million new cases of invasive breast cancer will be diagnosed in women in the United States this year, and approximately 40,000 …
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Statistical Methods For Two Problems In Cancer Research: Analysis of Rna-Seq Data From Archival Samples and Characterization of Onset of Multiple Primary Cancers
… important topics in translational and clinical cancer research.</p> <p>The first topic was motivated by the challenge of applying transcriptome sequencing (RNA-seq) to formalin-fixation and paraffin-embedding (FFPE) tumor samples for reliable diagnostic development. We designed a biospecimen …
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Analysis of breast tissue microarray spots
Tissue microarrays (TMAs) are a high-throughput technique that facilitates the survey of very large numbers of tumours, important both in clinical and research applications. However, the assessment of stained TMA sections is laborious and still needs to be carried manually, constituting a …
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Life Style, Molecular Pathology, and Breast Cancer Risk
The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
… and resemblance to a luminal morphology. Breast tumours surrounded by anisotropic (directional) collagen fibres running perpendicular to the tumour boundary are more aggressive and associated with poor patient prognosis. To recapitulate this anisotropic collagen phenotype in vitro, an …