Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 78 for “"Breast Cancer Metastasis"”.
-
Wnt-5a signaling in breast cancer metastasis
Breast cancer is the most common form of malignancy affecting women in the Western world. Today, anticancer treatment can control primary breast tumors, but treatment and prevention of metastatic disease still represents a major challenge in the management of breast cancer patients. It has been …
-
ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor …
-
Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
Breast cancer is the most common type of cancer among women in the United States and metastasis is the leading cause of mortality in patients diagnosed with malignant breast cancer. The receptor of thromboxane A2 (TxA2), TP, is a member of the G-protein coupled receptor family. Increased expression …
-
Regulation of Matrix Metallopeptidase-1 in Breast Cancer Metastasis
… repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials and identify a mechanism differentially regulating MMP-1. …
-
The effect of dietary genistein on breast cancer metastasis
… isoflavones may have the potential to alter breast cancer (BC) growth and metastasis which is also more common in the postmenopausal age group. In this study, we investigated the role of the main soy isoflavone, genistein, on the metastasis of 4T1 murine BC cells implanted in ovariectomized …
-
An investigation into the mechanisms of angiogenesis and breast cancer metastasis
Breast cancer survival rates have increased over the years due to early detection and therapeutic efficacy. However, after many years of what appears to be disease-free health, cancer can return in the form of a secondary metastatic tumour. Formation of new blood vessels is a crucial stage in the …
-
Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …
-
Effects of consuming thermally abused frying oil on breast cancer metastasis
… and their consumption is associated with breast cancer (BC) risk. Deep-frying food deteriorates oil through numerous physical, chemical and oxidative reactions, leading to the development of thermally abused frying oil (TAFO). These TAFOs contain diverse profiles of food processing-induced …
-
Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
Cancer metastasis is an important process in cancer progression. This process is facilitated by proteases that promote degradation of the extracellular matrix, cell migration and cell invasion. Angiogenesis is important to the metastatic process and also involves extracellular matrix degradation, …
-
Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
Metastasis is the principle cause of the deaths among breast cancer patients. Brain is one of the major sites of metastasis in breast cancer; however, the pathological mechanism is poorly understood. One of critical steps of brain metastasis is the breaching of the BBB and this process is …
-
HCMV Promotes Breast Cancer Metastasis: Impacts of CMVIL-10 in the Tumor Microenvironment
… that promote a more invasive tumor phenotype. Cancer cells that express fewer adhesion molecules, which allow cells to break off from the primary tumor, are more likely to metastasize. In addition, matrix metalloproteinases (MMPs) degrade the extracellular matrix, which promotes cancer cell …
-
AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… for the Doctor of Philosophy degree in Molecular Cancer Biology, presented on June 24th, 2015, at Southern Illinois University Carbondale. TITLE: AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY MAJOR PROFESSOR: Dr. Deliang Cao Aldo-keto reductase 1B10 …
-
Identification of TMEM2 as a SOX4 Transcriptional Target Involved in Breast Cancer Metastasis
… and has been shown to drive the progression and metastasis of multiple solid cancer types. A common transcriptional target of SOX4 that mediates its effects in multiple cancer types has yet to be identified. Through a systematic molecular and genomic approach, we identify the transmembrane …
-
The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
Breast cancer is a leading cause of cancer death in women. While locally-confined breast cancer is generally curable, the survival of patients with metastatic breast cancer is very poor. Treatment for metastatic breast cancer is palliative not curative due to the lack of targeted therapies. …
-
The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway
Breast cancer afflicts many individuals worldwide, however, survival rates diminish greatly when this disease becomes metastatic. Despite medical advances of therapies for breast cancer, metastatic breast cancer has high mortality and morbidity rates. Recently, gangliosides, a type of lipid, have …
-
The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… chemotherapeutic resistance in triple-negative breast cancer (TNBC) patients. The tumor microenvironment (TME) comprises various cell types that play a role in tumor survival and invasion by providing soluble factors such as pro-inflammatory cytokines IFN-γ, IL-1β, and TNF-α, which are known to …
-
Investigations into the dynamic uptake of extracellular vesicles and their role in breast cancer metastasis after chemotherapy
… been fully characterised. EVs play key roles in cancer including all the stages of metastasis. Breast cancer is amongst the most common types of cancer for women and the primary cause of cancer related death. The high mortality rates are due to the metastatic spread of cancer cells and tumour …
-
Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
<p>Metastasis is a highly complex, multi stage process that is clinically daunting, causing the majority of deaths from solid malignancies. A previous study identified three microRNAs that robustly suppresses breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 …
Page 1 of 4