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Showing 1 to 5 of 5 for “"Breast Cancer Brain Metastasis"”.
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
<p>Breast cancer brain metastases have remained one of the most intense challenges for precision cancer therapeutics, but current treatment options are limited and not curative. Recently, our lab reported that adoptive <em>PTEN</em> downregulation in metastatic breast tumor cells activates …
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Role of miR-4732-3p in breast cancer brain metastasis and brain metastatic tumor microenvironment
… (miRNAs) that may play important roles in breast cancer brain metastasis (BCBM). To this end, we conducted miRNA-sequencing of extracellular vesicles isolated from the serum samples of 6 BCBM patients and 8 Stage I/II/III breast cancer patients, and identified 49 circulating miRNAs that …
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
<p>Brain metastasis is a common cause of mortality in cancer patients. Approximately 20-30% of breast cancer patients acquire brain metastasis, yet potential therapeutic targets remain largely unknown. The type I insulin-like growth factor receptor (IGF- IR) is known to play a role in the …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… numerous diseases, including different types of cancer. Given the essential nature of glycans in crucial biological functions and their association with various health conditions when their expressions are altered, glycomics are becoming leading areas in the development of biomarkers. These …
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A proteomics study to investigate the role of the neural niche in the development of metastatic HER2+ breast cancer
… system to distant organs in a process known as metastasis. The brain, which is shielded from the environment by the blood brain barrier, offers an immunocompetent lodging spot for the circulating cancer cells. Therefore, it is a "popular" destination for metastasized cancers which even surpass …