Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2176 for “"Breast Cancer"”.
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Exploring inflammatory breast cancer
Contains fulltext : 217372.pdf (Publisher’s version ) (Open Access)
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Systems biology of breast cancer
Breast cancer, with an alarming incidence rate throughout the globe, has attracted significant investigations to identify disease specific biomarkers. Among these, oestrogen receptor (ER) occupies a central role where overexpression is a prognostic indication for breast cancer. The cross-talk …
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Physical activity and breast cancer
Background: Breast cancer is the most frequently diagnosed cancer and a leading cause of cancer death among females, both worldwide and in the UK. Although, UK incidence of breast cancer is rising, breast cancer mortality rates are falling, due largely to early detection and improved treatment. As …
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Molecular Epidemiology of Breast Cancer
Hereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously …
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Invadopodia Formation in Breast Cancer
Cancer progression can be driven by signalling via growth factors such as hepatocyte growth factor (HGF) and by the surrounding microenvironment. During initial tumour expansion intratumoral hypoxia can develop due to inadequate vasculature supply. To resist the negative effect of hypoxia, cells …
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Fusion genes in breast cancer
… recently been seen as unimportant in epithelial cancers. The discovery of recurrent fusion genes in prostate and lung cancer suggests that fusion genes may play an important role in epithelial carcinogenesis, and that they have been previously under-reported due to the difficulties of cytogenetic …
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either increase or decrease the transcriptional activity of Dmp1 depending the molecular contexts of the targeted genes. Although loss of Dmp1 significantly accelerated oncogenic neu induced mammary carcinogenesis in …
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Oncoproteomic applications for detection of breast cancer. Proteomic profiling of breast cancer models and biopsies
The heterogeneity of breast cancer (disease stage and phenotype) makes it challenging to differentiate between each subtype; luminal A, luminal B, HER2, basal-like and claudin-low, on the basis of a single gene or protein. Therefore, a collection of markers is required that can serve as a signature …
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The prevalence of breast cancer in Africa and establishment of The Libyan Breast Cancer Registry
Breast cancer is well-known globally and remains one of the principal health concerns affecting women, and a rare malignancy in men. Although, there has been significant progress made in prevention strategies such as early detection and better treatment in most developed countries, incidence and …
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Breast Cancer Risk For Female Relatives of Male Breast Cancer Patients With Negative Brca1/2 Testing
… exist to estimate a female’s lifetime risk of breast cancer in the absence of a hereditary predisposition to cancer, namely Hereditary Breast and Ovarian Cancer syndrome. These risk models consider various factors such as reproductive history and family history, but few models take a family …
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Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer.
One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of …
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The relationship between body mass index and breast cancer recurrence/progression and breast cancer-specific death
… association between body mass index (BMI) and breast cancer outcomes and to determine whether BMI improves prediction of outcomes. A cohort of906 breast cancer patients diagnosed at Henry Ford Health System, Detroit (1985-1990) were studied. The median follow-up was 10 years. Multivariate …
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Lymphoedema following surgery for breast cancer
… term complications of the surgical treatment of breast cancer and may be described as a life sentence of bodily disfigurement. The resultant cosmetic disfigurement, physical discomfort and reduced physical mobility combined with the psychological sequelae, far exceeds the original expectations of …
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A Fictional Exploration of Breast Cancer
… 16 years of age as her mother is diagnosed with breast cancer and they navigate her treatment.
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Gene expression analysis in breast cancer
Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug development may lie in understanding the …
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Evaluation of PBR in Breast Cancer
… Emission Tomography: PET) in the detection of cancer began with the radiopharmaceutical 2-[18F]fluoro-2-deoxyglucose: FDG) used for measuring altered cellular metabolism. Specific radioligands are being developed to allow non-invasive analysis of protein expression to further characterize …
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Inflammatory Breast Cancer: The Immune Perspective
<p>Inflammatory breast cancer (IBC) is the most insidious form of locally advanced disease. Although rare and less than 2% of all breast cancer, IBC is responsible for up to 10% of all breast cancer deaths. Despite the name, very little is known about the role of inflammation or immune mediators in …
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