Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Bre1"”.
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Regulation of Set1-Mediated Methylation of Dam1
… of histone H2BK123 by the E2-E3 ligases Rad6 and Bre1, as well as the Paf1 transcriptional elongation complex. This regulatory pathway exemplifies cross-talk <em>in trans</em> between posttranslational modifications on distinct histone molecules. Set1 has an additional substrate in the kinetochore …
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The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells
… of a functional human homologue, the hBRE1A/B complex, of the yeast BRE1 E3 ubiquitin ligase. hBRE1A, which forms a complex with hBRE1B, specifically increases the global level of H2B ubiquitylation at lysine 120 and enhances activator dependent transcription in vivo. An extensive …
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… H2B-K123 ubiquitylation, carried out by Rad6-Bre1, and histone H3 methylation on lysine 79 (H3-K79), performed by Dot1, contribute to Rad9 recruitment to chromatin. Infact, it has been demonstrated that Rad9 physically interacts with methylated H3-K79 thanks to its Tudor domain. Impairment of …