Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Branched chain aminotransferase"”.
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ELUCIDATING THE ROLE OF BCAT1 IN MITOCHONDRIAL FUNCTION AND NEURODEVELOPMENT
Branched-chain amino acids (BCAAs) are important nitrogen donors involved in various biochemical processes in the brain and comprise three essential amino acids: Leucine, Isoleucine, and Valine. Regulation of BCAA metabolism influences the central nervous system through multiple mechanisms, …
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The Role of Leucine and Its Metabolite (KIC) in Insulin Signalling and Glucose Transport in L6 Myotubes
Branched-chain Amino Acids (BCAAs) are known to have positive effects in metabolic health through weight management and muscle protein synthesis. However, elevated levels of BCAAs (particularly leucine) and their metabolites have also been implicated in the development of insulin resistance and …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
… Ketoisocaproic acid is a substrate for Branched Chain Aminotransferase 1 (BCAT1), the first enzyme in the catabolic pathway of Branched Chain Amino Acids. This enzyme is upregulated in many cancers and is linked to cancer progression. In this project, the role of BCAT1 in cell …
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A PROTEIN IN SEARCH OF FUNCTION: NIPSNAP1 IN MITOCHONDRIAL BRANCHED-CHAIN AMINO ACID METABOLON, BRAIN AND APOPTOSIS
… that contains the first two enzymes in branched-chain amino acid (BCAA) catabolism, the mitochondrial branched-chain aminotransferase (BCATm) and the branched-chain α-keto-acid dehydrogenase complex (BCKDC). Dysregulation of BCAA metabolism results in neurologic dysfunction. Studies in …