Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Brain--Physiology"”.
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Mast cells affect brain physiology and behavior
Mast cells are immune cells that are found in the brain. Behavioral and endocrine states increase the number and activation of brain mast cells, independent of the animal's immune status. Activation causes the release of many neuro-active mediators into the brain parenchyma. However, the function …
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Integrative and Scalable Pipeline for Multi-omic Characterization of Biological Tissues
… comprehensive characterization of the mammalian brain is crucial to understand brain physiology and neurological diseases. Depending on the goal of the study, various brain models, such as those involving mice, postmortem humans, and three-dimensional (3D) organoids derived from human induced …
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The effect of repetitive subconcussive head impacts on observed physiological, biochemical, and functional perturbances in the brain in high school and collegiate football players: a systematic literature review
… and neurophysiological performance, serum brain marker, diffusion-weighted tensor imaging changes, and head impact telemetry were outcomes of interest. Our initial search strategy identified 564 articles. After restricting to articles focused on subjects aged 13 to 24 years, 151 articles …
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Microdomain calcium oscillations in Drosophila glia regulate seizure susceptibility and require NCKX
… stores, and their relative importance in normal brain physiology has been disputed. Recently, near-membrane microdomain Ca²+ transients were identified in fine astrocytic processes and found to arise via an intracellular store- independent process. Here, we describe the identification of rapid, …
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Spatio-temporal fMRI signal analysis using information theory
Functional MRI is a fast brain imaging technique which measures the spatio-temporal neuronal activity. The development of automatic statistical analysis techniques which calculate brain activation maps from JMRI data has been a challenging problem due to the limitation of current understanding of …
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QUANTITATIVE ANALYSIS OF FLUORESCENT IMAGES OF GLIA CELLS USING DEEP NEURAL NETWORKS
The human brain is an incredibly intricate system comprising not only neurons but also another diverse group of cells known as glia. In recent years, there has been a remarkable surge in interest among neuroscientists regarding glia cells due to their crucial role in brain function. Among the …
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Cognitive Neurostimulation: Learning to Volitionally Invigorate Mesolimbic Reward Network Activation
<p>The brain’s dopaminergic system is critical to adaptive behaviors, and is centrally implicated in various pathologies. For decades, research has aimed at better characterizing what drives the mesolimbic dopamine system and the resulting influence on brain physiology and behavior in both humans …
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Measurement of Cerebral Metabolism and Vascular Function with Magnetic Resonance Imaging
The brain relies on oxidative metabolism to function properly. Cerebral metabolic rate of oxygen (CMRO2) is thus an important marker for brain health. Existing techniques for quantification of CMRO2 with positron emission tomography (PET) or magnetic resonance imaging (MRI) involve special …
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Assessing Pre-Frontal Cortex Oxygenation After Sport Concussion With Near Infrared Spectroscopy
… do not directly measure (or reliably track) brain physiology throughout concussion recovery. Because of these issues, there has been a call to find an objective biomarker that can index both severity and the timeline for recovery. An additional problem is that, with the amount of concussions …
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… can shape cognitive abilities by altering brain physiology or function. Here, I investigated how prenatal thermal environment and corticosterone (CORT) - a key stress hormone in reptiles - affects cognitive development in two species of skinks: the delicate skink (Lampropholis delicata), …
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… can shape cognitive abilities by altering brain physiology or function. Here, I investigated how prenatal thermal environment and corticosterone (CORT) - a key stress hormone in reptiles - affects cognitive development in two species of skinks: the delicate skink (Lampropholis delicata), …
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Measurement of Cerebral Blood Flow Using Arterial Spin Labeling Magnetic Resonance Imaging
… reflects the amount of blood perfusion in the brain, often defined as ml of blood per 100 gram of brain per minute. CBF is an important measure in understanding brain physiology and pathophysiology. Thus, it is important to establish a robust method suitable for longitudinal and cross-sectional …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… that gangliosides, membrane components of brain cells, especially neurons, can activate brain glial cells in vitro, thus could play roles in brain physiology and pathology. In this study, I tested whether gangliosides could induce the expression of immune molecules related to antigen …
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Arterial Spin-labelled MRI Analyses to Advance Adolescent Bipolar Disorder Research and Clinical Applications
Cerebral blood flow (CBF) is foundational to brain function in health and disease. Through three distinct analyses, the aim of this thesis is to extend current understanding of CBF in adolescent bipolar disorder and to enable future understanding of CBF in other brain diseases. CBF measurement can …
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Testing and Analysis of a Computational Model of Human Rhythm Perception
… with other models that relate more directly to brain physiology. In each case, all relevant behaviours were found to be closely in line. Lastly, the outputs of the model under polyrhythmic stimuli were analysed to make new testable predictions about previously unobserved human behaviour …
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Imaging Glutamate In The Human Brain At Ultra-High Magnetic Field: Advances And Applications
… of the primary neurotransmitters in the human brain, and many unanswered questions in neuroscience, psychiatry and medicine revolve around this molecule: its production, transport, conversion or degradation, regulation and effects. Yet, to date, methods for actually measuring glutamate within …
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Genetic studies on functional redundancy between profilin1 and profilin2 im mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior
… and adulthood in most tissues including brain, profilin2 is the neuronal specific isoform. Lack of profilin1 results in early embryonic lethality, while profilin2 KO mice are viable and show behavioral abnormalities. In this thesis I aimed to address three major questions: 1.Is there …
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Dissertations on decision-making: similarity, constructive judgements, morality and social dilemmas
… not about the application of quantum physics to brain physiology. Rather, we are interested in QP theory as a mathematical framework for cognitive modelling. This theory is potentially relevant in any behavioural situation that involves uncertainty. QP theory is analogous to classical probability …
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… immune cells of the CNS. Present throughout the brain parenchyma and in constant communication with the peripheral immune system, microglia are essential regulators of brain physiology. The adult human brain is prone to immune dysregulation in neurodegeneration and normal ageing. Understanding …
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