Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Brain tumours"”.
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Molecular biology and biochemistry of brain tumours
… some molecular mechanisms and biochemistry of brain tumours is an important step towards the development of adjuvant medical therapies. The present study concentrates on cholecystokinin (CCK), a gut-brain peptide that has been described to be able to induce mitosis of rat gliomas as well as …
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The Investigation of Targets for Therapy in Brain Tumours
Gliomas are among the most difficult of tumours to treat. Their highly invasive nature leads to recurrence even after aggressive therapy including surgery, radiotherapy and chemotherapy. A promising target for new therapies are tyrosine kinases, because they regulate a large range of proteins …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… individuals to develop multiple nervous system tumours, primarily schwannoma, meningioma and ependymoma. NF2 is characterised by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations of the encoding gene NF2 or by loss of heterozygosity. These tumours can occur either …
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Diagnostic Neuropathology of Brain Tumours using Biophotonics and Spectrometry
Classification of tumours such as gliomas, which are on a continuous spectrum of histology and malignancy into distinct categories is still a challenge using histopathology. There has been significant advances in the techniques used to fight cancer in the past two decades. A number of studies have …
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Modelling brain tumours with network neurosciences and deep learning
Glioma is one of the most common and lethal brain tumours. The clinical diagnosis and prognosis of glioma are challenging due to its heterogeneous nature. In the past, glioma was considered a focal disease with local disruption to the brain. However, recent studies suggested that tumour cells would …
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Paediatric brain tumours: The University of Cape Town experience from 1996 - 2017
Brain tumours are the second most common malignancy in children(1) (2), and despite some advancements being made over the last 2 decades, patient outcomes in general remain poor when compared with other childhood cancers. Optimal treatment of children with brain tumours is challenging and expertise …
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Profiling medulloblastoma and juvenile pilocytic astrocytoma brain tumours in a South African paediatric cohort
Brain tumours in children are one of the most challenging diseases to treat, and so outcomes are variable and often lacking. There are currently no reliable data of presentation of disease, the spectrum of tumours treated, how these are treated, and what the outcomes are for children in South …
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Neuropsychological sequelae of paediatric posterior fossa brain tumours : the effect on quality of life
Bibliography: leaves 248-285.
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Short echo time single voxel magnetic resonance spectoscopy in the characterisation of childhood brain tumours.
INTRODUCTION Brain tumours are the most common solid tumour in childhood, while Magnetic Resonance Spectroscopy (MRS) studies have been performed on brain tumours previously, the majority have been performed on the adult patient population and at long echo times. The work presented in this thesis …
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The use of conventional and advanced magnetic resonance techniques in the assessment of primary brain tumours
… methods in the management of patients with these brain tumours. Thirty-six patients were studied at the National Hospital for Neurology and Neurosurgery using conventional, perfusion-weighted and diffusion-weighted MRI at study entry and 6 monthly intervals thereafter. At each visit, tumour …
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Development of positioning devices for MRI-guided high intensity focused ultrasound (HIFU) for abdominal, thyroid and brain, tumours
… procedures in many areas such as the brain, eye, breast, kidney, liver, pancreas, thyroid, uterine fibroids and pancreas. Meanwhile, new investigations are underway for treading cardiac arithmia, strokes, palliative pain treatment of bone metastases and brain disorders such as …
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Investigating the use of Raman spectroscopy as a histopathological tool to identify metastatic brain tumours and their sites of origin
… that 13,000 people in the UK are diagnosed with tumours in the brain every year, of which 60% are metastatic. Current methods for diagnosing the disease can be subjective, invasive and have long diagnostic windows. Raman spectroscopy provides a non-destructive, non-invasive, rapid and economical …
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An NMR study of human brain tumours: Phosphorus chemical shift imaging in vivo and high resolution proton spectroscopy of biopsy samples.
Human brain tumours have been investigated using proton and phosphorus nuclear magnetic resonance (NMR). The localization technique, chemical shift imaging has been used to obtain phosphorus spectra of tumours in vivo. High resolution proton spectroscopy has been performed on biopsy samples and …
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Evaluation of the therapeutic potential of red clover extract and red grape seed extract on human adult malignant brain tumours in vitro
Gliomas are rare intrinsic brain tumours which account for 2% of all cancers. Glioblastoma multiforme is the most malignant malignant glioma form and remains incurable. The biological features which preclude successful therapy include heterogeneity, diffuse invasive patterns and angiogenesis. …
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An automated system for the classification and segmentation of brain tumours in MRI images based on the modified grey level co-occurrence matrix
… for the classification and segmentation of brain tumours in MRI scans remains challenging due to high variability and complexity of the brain tumours. Visual examination of MRI scans to diagnose brain tumours is the accepted standard. However due to the large number of MRI slices that are …
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A study on the application of independent component analysis to \(in vivo\) \(^1\)H magnetic resonance spectra of childhood brain tumours for data processing
Independent component analysis (ICA) has the potential of automatically determining metabolite, macromolecular and lipid (MMLip) components that make up magnetic resonance (MR) spectra. However, the realiability with which this is accomplished and the optimal ICA approach for investigating in vivo …
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Simulation studies on X-ray imaging of brain parenchyma and tumors
… to image the tissues in the parenchyma of the brain and brain tumours in early stages. Aim of the presented research is to investigate whether CT could be used to image the soft tissue of the brain since this would provide an extremely powerful tool in the hand of the clinicians. CT due to its …
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Advancing Automatic Brain Tumour Segmentation Using Multi-Modal MRI
Brain tumours are characterised by the uncontrolled growth of abnormal cells within or around the brain. Early and accurate detection of these tumours is imperative for improving patient outcomes, significantly enhanced through rapid and precise tumour segmentation in medical imaging. While manual …
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An automated classification system to determine malignant grades of brain tumour (glioma) in magnetic resonance images based on meta-trainable multiple classifier schemes
… accurate classification of malignant grades of brain tumours is crucial for therapeutic planning as it impacts on the tumour’s prognosis, where the higher the malignancy levels of the brain tumour are, the higher the mortality rate is. It is also essential to provide patients with appropriate …
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The experience of low grade and pituitary tumours
Low grade brain tumours make up approximately 45% of all brain tumour diagnoses each year in the UK, of which 10% are pituitary tumours. People with low grade and pituitary tumours can experience a wide range of physical, psychological and cognitive difficulties. Studies have reported mixed results …
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