Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Brain tissues"”.
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Advanced neural networking and classification techniques for human brain tissues diagnoses: segmenting healthy, cancer affected and edema brain tissues
The brain tumors, are the most common and aggressive disease, leading to a very short life expectancy in their highest grade. Thus, treatment planning is a key stage to improve the quality of life of patients. Generally, various image techniques such as Computed Tomography (CT), Magnetic Resonance …
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Backscatter And Attenuation Properties Of Mammalian Brain Tissues
Traumatic Brain Injury (TBI) is a comcategory of brain injuries, which contributes to a substantial number of deaths and permanent disability all over the world. Ultrasound technology plays a major role in tissue characterization due to its low cost and portability that could be used to bridge a …
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Liquid chromatographic separation and quantitation of B-6 vitamers in rat liver, kidney, and brain tissues
… the B-6 vitamers from rat livers, kidneys, and brains. PL values were derived from the sum of tissue PL and pyridoxal phosphate (PLP), the latter having been dephosphorylated to PL. Similarly, PN values were the sum of tissue PN and pyridoxine phosphate (PNP) and PM data the sum of PM and …
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Automatic detection and segmentation of brain lesions from 3D MR and CT images
The detection and segmentation of brain pathologies in medical images is a vital step which helps radiologists to diagnose a variety of brain abnormalities and set up a suitable treatment. A number of institutes such as iThemba LABS still rely on a manual identification of abnormalities. A manual …
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Droplet-Based Microfluidics for High-Throughput Single-Cell Omics Profiling
… to separately profile mixed cell lines, mouse brain tissues, and human brain tissues to reveal cell type heterogeneity. Second, the new Drop-ChIP platform only requires two steps of droplet generation to achieve multiple steps of reactions in droplets such as single-cell lysis, chromatin …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… Chronic neuroinflammation leads to disruptive brain functioning and can cause neurodegenerative diseases. Coronavirus disease 2019 (COVID-19) is an infectious disease spread rapidly across the world, threatening global health and causing huge economic losses. This work involves the development …
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Nucleosome repositioning in glioblastoma
… multiforme (GBM) is the most malignant type of brain cancer in adults, with highly aggressive behaviour and low patient survival. The glial cells that are responsible for forming GBM show abnormalities in gene expression that can be caused by genetic or epigenetic causes. In particular, the …
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Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
… of the intrinsic vulnerability of healthy human brain tissues to Alzheimer’s disease. This was achieved by studying the gene expression patterns in brain regions involved in the staging of AD – the Braak regions of the brain. Secondly, we described how this fingerprint was differentially …
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Androgen aromatization and cytosol estradiol-receptors in the mediation of masculine sexual behavior in Japanese quail
… frequency. Experiments were conducted with brain tissues from functionally castrated, High (HM) and Low Mating (LM) line quail to compare (1) the in vivo aromatization of ³H-testosterone and (2) cytosolic estradiol-binding by in vitro saturation analyses. After in vivo incubation with …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… gene (bcl-2) in human glioma compared to normal brain tissues and cell lines. Glioma and normal astrocyte cell lines have been employed for CD133 isolating purposes to characterise the association with MDR related genotype and phenotype. The chemosensitivity of the isolated CD 133 population was …
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Timing recombinant prion protein conversion as a measure of prion activity in chronic wasting disease
… at least as sensitive for detecting elk CWD in brain tissues as Tg(CerPrP-M132)1536+/- and Tg(CerPrP-E226)5037+/- mouse bioassay models. The assay performs within a period of 35 hours, is consistently reproducible, and functions on elk brain and tonsil tissues. There are indications RePLICA has …
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Integrated and scalable molecular brain mapping
Understanding the brain requires integrative knowledge of its cellular-, network-, and system-level architectures. Existing volume imaging techniques have proven the potential to provide such information, but the lack of technology to label large volumes for visualization has limited their utility. …
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Deep Learning for Brain Structural Connectivity Analysis: From Tissue Segmentation to Tractogram Alignment
… is a cornerstone in neuroimaging for studying brain anatomy and functions. Anatomical MRI images, such as T1-weighted (T1-w) scans, allow the non-invasive visualization of the brain tissues, enabling the investigation of the brain morphology and facilitating the diagnosis of both acquired …
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A subspace method for reconstruction of time-series fMRI images from sparse data
… powerful imaging modality commonly used to study brain functions. It utilizes the difference in the oxygen content of brain tissues over time to produce functional connectivity maps, or visualizations of brain regions activated when a subject performs a task. As such, it provides invaluable insight …
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Developing digital and analog spiking neural Networks for interacting with biological Tissues in the Case Study of temporal lobe Epilepsy
… capable of recording local field potentials from brain tissues, particularly, rodent brain slices. This real-time interaction with brain tissues through the MEA system presented opportunities to validate the functionality of the SNN in a physiological context. The implementation of the SNN began …
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Investigating the pathogenesis and therapy of Friedreich Ataxia
… elevated levels of frataxin protein in the brain tissues were obtained with RGFP 109, suggesting that RGFP 109 is capable of crossing the blood-brain barrier. I have also found increased levels of global acetylated H3 and H4 histone proteins in brain tissues, along with significant increase …
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Microfluidics for Genetic and Epigenetic Analysis
… the neuronal/glial nuclei isolated from mouse brain tissues. We successfully identified the distinctive epigenomic signatures from neurons and glia. Another focus of this thesis is applying electrical field to investigate the intracellular contents. We report two projects, drug delivery to …
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Mechanics of blast-induced traumatic brain injury in porcine brain tissue
<p>Blast-induced traumatic brain injury (bTBI) often results from the detonation of improvised explosive devices (IEDs) in war settings. However, the material properties of the brain and their changes during and after bTBI are currently not well understood. Characterizing brain tissue is …
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Feasibility study of trans-cranial Direct Current Stimulation in presence of Brain tumor
… shown that the current flow patterns within the brain are altered due to the presence of lesioned brain tissues[2]. Here we present the first investigations of the use of tDCS in patients with brain tumors. We created a brain model from MRI scans of a patient who had a left hemisphere …
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Bromethalin-based rodenticides: Mode of action, toxicity, clinical effects, and treatment efficacy in rats, dogs, and cats
… vacuolization. Ultramicroscopic examination of brainstem revealed occasional swollen axons, intramyelenic vacuolization, and myelin splitting at the intraperiod line. Bromethalin was detected in kidney, liver, fat, and brain tissues using gas chromatography with electron capture detection. …
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