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Showing 1 to 20 of 364 for “"Brain tissue"”.
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Nonlinear Viscoelastic Wave Propagation in Brain Tissue
… to determine that shock waves can form in brain tissue from smooth boundary conditions. The conditions that lead to the formation of shock waves were determined. The implication of this finding was that the high gradients of stress and strain that could occur at the shock wave front could …
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Dynamic Deformation and Mechanical Properties of Brain Tissue
<p>Traumatic brain injury is an important medical problem affecting millions of people. Mathematical models of brain biomechanics are being developed to simulate the mechanics of brain injury and to design protective devices. However, because of a lack of quantitative data on brain-skull boundary …
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Segmentation of brain tissue from magnetic resonance images
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Dose-Effect Relationships for Ultrasound Irradiation of Brain Tissue
Made available in DSpace on 2014-12-14T05:40:44Z (GMT). No. of bitstreams: 1 7915373.pdf: 3243153 bytes, checksum: 2c7e6604619722641892532e7953509e (MD5) Previous issue date: 1979
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Recognizing Brain Regions in 2D Images from Brain Tissue
… visualization of the anatomy of the brain, capturing physical characteristics like the size and shape of different regions of the brain or the presence of abnormalities such as tumors. Whereas sMRI are more commonly taken in vivo, the neuropathology of many neurodegenerative …
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Determining the partial volumes of brain tissue from spectroscopy voxels
MS tai magneettispektroskopia on kuvantamistekniikka, jolla saadaan tietoa kudosten metaboli ittikonsentraatioista tietystä tilavuudesta. Näistä konsentraatioarvoista voidaan tehdä potilaan diagnostiikkaan vaikuttavia johtopäätöksiä. Tekniikkaa voidaan käyttää myös aivokuvantamisessa. Aivot …
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Temperature elevations due to NIR exposure in the brain tissue
… Temperature elevation profile inside the tissue is a critical factor that needs to be better understood in these applications. The purpose of this study is to determine the temperature distribution due to a low power N I R laser irradiation in living neural tissue. Temperature measurements …
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Sex Differences in Catecholamine Release From Brain Tissue in Vitro
… of endogenous catecholamines (CA) from rat brain tissue. This system was employed to measure CA release from 2 brain areas, the mediobasal hypothalamus (MBH) and the striatum. The K('+)-stimulate
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Effects of swelling on brain tissue mechanical properties by indentation
Constructing more in-depth models of the brain’s behavior has gained significant attention in recent years, particularly for the goal of modeling brain injury and function. Mechanical studies have improved in effectiveness with the development of more standard testing protocols and the contribution …
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Mechanical characterization of mammalian brain tissue and energy dissipative polymers
The high incidence of traumatic brain injury due to adverse impact events ranging from head collisions to ballistic attacks has prompted significant interest in synthetic polymer gels capable of mimicking key mechanical properties of brain tissue. These so-called brain tissue simulants are valuable …
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Mechanics of blast-induced traumatic brain injury in porcine brain tissue
<p>Blast-induced traumatic brain injury (bTBI) often results from the detonation of improvised explosive devices (IEDs) in war settings. However, the material properties of the brain and their changes during and after bTBI are currently not well understood. Characterizing brain tissue is …
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Methods to measure and relate the viscoelastic properties of brain tissue
Measurement of brain tissue elastic and viscoelastic properties is of interest for modeling traumatic brain injury, understanding and creating new biomarkers for brain diseases, improving neurosurgery procedures and development of tissue surrogate materials for evaluating protective strategies …
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Generating Predictive Gene Expression Signatures for Alzheimer's Disease Using Postmortem Brain Tissue
… These pathological features develop in specific brain regions, but why some areas are more vulnerable to early AD-related changes remains unclear. To address this, predictive gene expression signatures were developed to explore the molecular mechanisms underlying regional susceptibility to AD …
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The effect of mild traumatic brain injury on cytokine expression in brain tissue
Previous research suggests that mild traumatic brain injury (mTBI) results in significant cognitive and behavioral learning deficit, as well as long-term depressive like behavior in mice. mTBI has been identified as a major initiating event in long-term depressive-like behavior and early fatality …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis was to develop a collagen scaffold for the non-viral delivery of the gene …
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Measurement and modeling of brain tissue and engineered polymer response to concentrated impact loading
Our brains are among the most mechanically compliant and structurally complex organs in our bodies. To predict how brain tissue deforms, and to protect it from deforming in ways that reduce our cognitive function, we must be able to measure, model, and ideally replicate brain tissue mechanics. …
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Scalable algorithms for semi-automatic segmentation of electron microscopy images of the brain tissue
… for segmenting very large 3D images of brain tissue. Currently, light and electron microscopy can now produce terascale 3D images within hours. Extracting the information about the shapes and connectivity of the neurons require fast and accurate image segmentation algorithms. Due to the …
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EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
Primary and metastatic brain cancers are commonly treated with partial or whole-brain irradiation (WBI). Twenty to fifty percent of patients that receive WBI develop progressive cognitive dysfunction caused by injury to irradiated normal brain tissue. The cellular and molecular mechanisms …
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Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics
… but single sections—obtained by cutting brain samples with a diamond knife—must be “ultrathin” (< 40 nanometers), thus requiring 25,000 consecutive sections to be processed. Currently, the processing of ultrathin sections remains an unsolved problem that is necessary for the advancement …
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Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts
… accumulation of abnormal protein deposits in the brain. This study aimed to explore alterations in different autophagy pathway linked proteins with AD progression and find the relationship between MA and CMA. Immunohistochemical/double labelling techniques were performed on post-mortem human brain …
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